Search Results - "Tsuchiyama, Scott"

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae by Kruegel, Undine, Robison, Brett, Dange, Thomas, Kahlert, Günther, Delaney, Joe R, Kotireddy, Soumya, Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Murakami, Christopher J, Schleit, Jennifer, Sutphin, George, Carr, Daniel, Tar, Krisztina, Dittmar, Gunnar, Kaeberlein, Matt, Kennedy, Brian K, Schmidt, Marion

“…Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component…”
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Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals “aging factors” and mechanism of lifespan asymmetry by Yang, Jing, McCormick, Mark A., Zheng, Jiashun, Xie, Zhengwei, Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, El-Samad, Hana, Ouyang, Qi, Kaeberlein, Matt, Kennedy, Brian K., Li, Hao

“…Budding yeast divides asymmetrically, giving rise to a mother cell that progressively ages and a daughter cellwith full lifespan. It is generally assumed that…”
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A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan by Kwan, Elizabeth X, Foss, Eric J, Tsuchiyama, Scott, Alvino, Gina M, Kruglyak, Leonid, Kaeberlein, Matt, Raghuraman, M K, Brewer, Bonita J, Kennedy, Brian K, Bedalov, Antonio

“…Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative…”
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Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import by He, Chong, Tsuchiyama, Scott K, Nguyen, Quynh T, Plyusnina, Ekaterina N, Terrill, Samuel R, Sahibzada, Sarah, Patel, Bhumil, Faulkner, Alena R, Shaposhnikov, Mikhail V, Tian, Ruilin, Tsuchiya, Mitsuhiro, Kaeberlein, Matt, Moskalev, Alexey A, Kennedy, Brian K, Polymenis, Michael

“…The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general…”
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Inactivation of Yeast Isw2 Chromatin Remodeling Enzyme Mimics Longevity Effect of Calorie Restriction via Induction of Genotoxic Stress Response by Dang, Weiwei, Sutphin, George L., Dorsey, Jean A., Otte, Gabriel L., Cao, Kajia, Perry, Rocco M., Wanat, Jennifer J., Saviolaki, Dimitra, Murakami, Christopher J., Tsuchiyama, Scott, Robison, Brett, Gregory, Brian D., Vermeulen, Michiel, Shiekhattar, Ramin, Johnson, F. Brad, Kennedy, Brian K., Kaeberlein, Matt, Berger, Shelley L.

“…ATP-dependent chromatin remodeling is involved in all DNA transactions and is linked to numerous human diseases. We explored functions of chromatin remodelers…”
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Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1 by Yao, Yanhua, Tsuchiyama, Scott, Yang, Ciyu, Bulteau, Anne Laure, He, Chong, Robison, Brett, Tsuchiya, Mitsuhiro, Miller, Delana, Briones, Valeria, Tar, Krisztina, Potrero, Anahi, Friguet, Bertrand, Kennedy, Brian K, Schmidt, Marion

“…Elevated proteasome activity extends lifespan in model organisms such as yeast, worms and flies. This pro-longevity effect might be mediated by improved…”
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Vacuolar dynamics and replicative aging by Tsuchiyama, Scott, Kennedy, Brian K.

“…Comment on: Gebre S, et al. Cell Cycle 2012; 11:2176-88…”
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A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging by McCormick, Mark A., Delaney, Joe R., Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Shemorry, Anna, Sim, Sylvia, Chou, Annie Chia-Zong, Ahmed, Umema, Carr, Daniel, Murakami, Christopher J., Schleit, Jennifer, Sutphin, George L., Wasko, Brian M., Bennett, Christopher F., Wang, Adrienne M., Olsen, Brady, Beyer, Richard P., Bammler, Theodor K., Prunkard, Donna, Johnson, Simon C., Pennypacker, Juniper K., An, Elroy, Anies, Arieanna, Castanza, Anthony S., Choi, Eunice, Dang, Nick, Enerio, Shiena, Fletcher, Marissa, Fox, Lindsay, Goswami, Sarani, Higgins, Sean A., Holmberg, Molly A., Hu, Di, Hui, Jessica, Jelic, Monika, Jeong, Ki-Soo, Johnston, Elijah, Kerr, Emily O., Kim, Jin, Kim, Diana, Kirkland, Katie, Klum, Shannon, Kotireddy, Soumya, Liao, Eric, Lim, Michael, Lin, Michael S., Lo, Winston C., Lockshon, Dan, Miller, Hillary A., Moller, Richard M., Muller, Brian, Oakes, Jonathan, Pak, Diana N., Peng, Zhao Jun, Pham, Kim M., Pollard, Tom G., Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Robison, Brett, Rodriguez, Ariana A., Ros, Bopharoth, Sage, Michael, Singh, Manpreet K., Smith, Erica D., Snead, Katie, Solanky, Amrita, Spector, Benjamin L., Steffen, Kristan K., Tchao, Bie Nga, Ting, Marc K., Vander Wende, Helen, Wang, Dennis, Welton, K. Linnea, Westman, Eric A., Brem, Rachel B., Liu, Xin-guang, Suh, Yousin, Zhou, Zhongjun, Kaeberlein, Matt, Kennedy, Brian K.

“…Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and…”
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Proteasomes, Sir2, and Hxk2 Form an Interconnected Aging Network That Impinges on the AMPK/Snf1-Regulated Transcriptional Repressor Mig1: e1004968 by Yao, Yanhua, Tsuchiyama, Scott, Yang, Ciyu, Bulteau, Anne Laure, He, Chong, Robison, Brett, Tsuchiya, Mitsuhiro, Miller, Delana, Briones, Valeria, Tar, Krisztina, Potrero, Anahi, Friguet, Bertrand, Kennedy, Brian K, Schmidt, Marion

“…Elevated proteasome activity extends lifespan in model organisms such as yeast, worms and flies. This pro-longevity effect might be mediated by improved…”
Get full text

Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import: e1004860 by He, Chong, Tsuchiyama, Scott K, Nguyen, Quynh T, Plyusnina, Ekaterina N, Terrill, Samuel R, Sahibzada, Sarah, Patel, Bhumil, Faulkner, Alena R, Shaposhnikov, Mikhail V, Tian, Ruilin, Tsuchiya, Mitsuhiro, Kaeberlein, Matt, Moskalev, Alexey A, Kennedy, Brian K, Polymenis, Michael

“…The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general…”
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A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan: e1003329 by Kwan, Elizabeth X, Foss, Eric J, Tsuchiyama, Scott, Alvino, Gina M, Kruglyak, Leonid, Kaeberlein, Matt, Raghuraman, M K, Brewer, Bonita J, Kennedy, Brian K, Bedalov, Antonio

“…Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative…”
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Sir2 deletion prevents lifespan extension in 32 long‐lived mutants by Delaney, Joe R., Sutphin, George L., Dulken, Ben, Sim, Sylvia, Kim, Jin R., Robison, Brett, Schleit, Jennifer, Murakami, Christopher J., Carr, Daniel, An, Elroy H., Choi, Eunice, Chou, Annie, Fletcher, Marissa, Jelic, Monika, Liu, Bin, Lockshon, Daniel, Moller, Richard M., Pak, Diana N., Peng, Qi, Peng, Zhao J., Pham, Kim M., Sage, Michael, Solanky, Amrita, Steffen, Kristan K., Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Johnson, Simon, Raabe, Chris, Suh, Yousin, Zhou, Zhongjun, Liu, Xinguang, Kennedy, Brian K., Kaeberlein, Matt

“…Summary Activation of Sir2 orthologs is proposed to increase lifespan downstream of dietary restriction. Here, we describe an examination of the effect of 32…”
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Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae: e1002253 by Kruegel, Undine, Robison, Brett, Dange, Thomas, Kahlert, Günther, Delaney, Joe R, Kotireddy, Soumya, Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Murakami, Christopher J, Schleit, Jennifer, Sutphin, George, Carr, Daniel, Tar, Krisztina, Dittmar, Gunnar, Kaeberlein, Matt, Kennedy, Brian K, Schmidt, Marion

“…Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component…”
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Sirtuins in yeast: phenotypes and tools by Tsuchiyama, Scott, Kwan, Elizabeth, Dang, Weiwei, Bedalov, Antonio, Kennedy, Brian K

“…Originally discovered as a transcriptional silencing protein, SIR2 was later linked to yeast replicative aging and the rest was history. Sir2p is now known to…”
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