Search Results - "Tsuchida, Hitomi"

Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals by Uenoyama, Yoshihisa, Tsuchida, Hitomi, Nagae, Mayuko, Inoue, Naoko, Tsukamura, Hiroko

“…Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery…”
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Effect of diet-induced obesity on kisspeptin-neurokinin B-dynorphin A neurons in the arcuate nucleus and luteinizing hormone secretion in sex hormone-primed male and female rats by Minabe, Shiori, Iwata, Kinuyo, Tsuchida, Hitomi, Tsukamura, Hiroko, Ozawa, Hitoshi

“…•In male rats, a high-fat diet (HFD) for four months suppressed Kiss1 and Pdyn gene expressions in the hypothalamic arcuate nucleus (ARC).•HFD for four months…”
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Central somatostatin-somatostatin receptor 2 signaling mediates lactational suppression of luteinizing hormone release via the inhibition of glutamatergic interneurons during late lactation in rats by SUGIMOTO, Arisa, TSUCHIDA, Hitomi, NAGAE, Mayuko, INOUE, Naoko, UENOYAMA, Yoshihisa, TSUKAMURA, Hiroko

“…Reproductive function is suppressed during lactation owing to the suckling-induced suppression of the kisspeptin gene (Kiss1) expression in the arcuate nucleus…”
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Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction by Uenoyama, Yoshihisa, Nagae, Mayuko, Tsuchida, Hitomi, Inoue, Naoko, Tsukamura, Hiroko

“…Increasing evidence accumulated during the past two decades has demonstrated that the then-novel kisspeptin, which was discovered in 2001, the known…”
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Hindbrain Adenosine 5-Triphosphate (ATP)-Purinergic Signaling Triggers LH Surge and Ovulation via Activation of AVPV Kisspeptin Neurons in Rats by Inoue, Naoko, Hazim, Safiullah, Tsuchida, Hitomi, Dohi, Yuri, Ishigaki, Ren, Takahashi, Ai, Otsuka, Yuki, Yamada, Koki, Uenoyama, Yoshihisa, Tsukamura, Hiroko

“…Ovulation disorders are a serious problem for humans and livestock. In female rodents, kisspeptin neurons in the anteroventral periventricular nucleus (AVPV)…”
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Enkephalin-δ opioid receptor signaling partly mediates suppression of LH release during early lactation in rats by TSUCHIDA, Hitomi, TAKIZAWA, Marina, NONOGAKI, Miku, INOUE, Naoko, UENOYAMA, Yoshihisa, TSUKAMURA, Hiroko

“…Gonadal function is often suppressed during lactation in mammals including rodents, ruminants, and primates. This suppression is thought to be mostly due to…”
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Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse Suppression in Lactating Rats by Sugimoto, Arisa, Tsuchida, Hitomi, Ieda, Nahoko, Ikegami, Kana, Inoue, Naoko, Uenoyama, Yoshihisa, Tsukamura, Hiroko

“…Abstract Follicular development and ovulation are profoundly suppressed during lactation in mammals. This suppression is suggested to be mainly due to the…”
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Central δ/κ opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation by UENOYAMA, Yoshihisa, NONOGAKI, Miku, TSUCHIDA, Hitomi, TAKIZAWA, Marina, MATSUZAKI, Sena, INOUE, Naoko, TSUKAMURA, Hiroko

“…In mammals, secretion of tonic (pulsatile) gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) is often suppressed during lactation. Suppression of…”
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Metformin action in the gut―insight provided by [18F]FDG PET imaging by Tsuchida, Hitomi, Morita, Yasuko, Nogami, Munenobu, Ogawa, Wataru

“…Suppression of hepatic gluconeogenesis is thought to largely underlie the antidiabetes action of metformin. However, this drug also exerts various effects on…”
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Sex difference in developmental changes in visualized Kiss1 neurons in newly generated Kiss1-Cre rats by YAMADA, Koki, NAGAE, Mayuko, MANO, Tetsuya, TSUCHIDA, Hitomi, HAZIM, Safiullah, GOTO, Teppei, SANBO, Makoto, HIRABAYASHI, Masumi, INOUE, Naoko, UENOYAMA, Yoshihisa, TSUKAMURA, Hiroko

“…Hypothalamic kisspeptin neurons are master regulators of mammalian reproduction via direct stimulation of gonadotropin-releasing hormone and consequent…”
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Type 2 Myocardial Infarction Caused by Orthostatic Hypotension With Post-transcatheter Aortic Valve Implantation: A Case Report by Tsuchida, Hitomi, Amano, Shiho, Sano, Chiaki, Ohta, Ryuichi

“…This case report delineates the occurrence and management of type 2 myocardial infarction (MI) in an 89-year-old woman following transcatheter aortic valve…”
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Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats by Nagae, Mayuko, Yamada, Koki, Enomoto, Yuki, Kometani, Mari, Tsuchida, Hitomi, Panthee, Arvinda, Nonogaki, Miku, Matsunaga, Nao, Takizawa, Marina, Matsuzaki, Sena, Hirabayashi, Masumi, Inoue, Naoko, Tsukamura, Hiroko, Uenoyama, Yoshihisa

“…The gonadotropin-releasing hormone (GnRH) pulse and surge are considered to be generated by arcuate kisspeptin/neurokinin B/dynorphin A (KNDy) neurons and…”
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Upregulation of S100A10 in metastasized breast cancer stem cells by Yanagi, Hisano, Watanabe, Takashi, Nishimura, Tatsunori, Hayashi, Takanori, Kono, Seishi, Tsuchida, Hitomi, Hirata, Munetsugu, Kijima, Yuko, Takao, Shintaro, Okada, Seiji, Suzuki, Motoshi, Imaizumi, Kazuyoshi, Kawada, Kenji, Minami, Hironobu, Gotoh, Noriko, Shimono, Yohei

“…Metastatic progression remains the major cause of death in human breast cancer. Cancer cells with cancer stem cell (CSC) properties drive initiation and growth…”
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AVPV Kiss1 neuron-specific knockdown of purinergic P2X2 receptor suppresses LH surge and ovulation in Kiss1-Cre rats by HAZIM, Safiullah, SEKI, Shunsuke, YABUSHITA, Ryoya, NAGAE, Mayuko, TSUCHIDA, Hitomi, HIRABAYASHI, Masumi, UENOYAMA, Yoshihisa, TSUKAMURA, Hiroko, INOUE, Naoko

“…Ovulation disorders are a major cause of low pregnancy rates and infertility in humans and livestock. Kisspeptin neurons located in the anteroventral…”
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Intronic Enhancer Is Essential for Nr5a1 Expression in the Pituitary Gonadotrope and for Postnatal Development of Male Reproductive Organs in a Mouse Model by Shima, Yuichi, Miyabayashi, Kanako, Mori, Takami, Ono, Koji, Kajimoto, Mizuki, Cho, Hae Lim, Tsuchida, Hitomi, Uenoyama, Yoshihisa, Tsukamura, Hiroko, Suzuki, Kentaro, Choi, Man Ho, Toida, Kazunori

“…Nuclear receptor subfamily 5 group A member 1 (NR5A1) is expressed in the pituitary gonadotrope and regulates their differentiation. Although several…”
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Enkephalin-δ opioid receptor signaling partly mediates suppression of LH release during early lactation in rats by TSUCHIDA, Hitomi, TAKIZAWA, Marina, NONOGAKI, Miku, INOUE, Naoko, UENOYAMA, Yoshihisa, TSUKAMURA, Hiroko

“…Gonadal function is often suppressed during lactation in mammals including rodents, ruminants, and primates. This suppression is thought to be mostly due to…”
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Dynorphin-κ-opioid receptor signaling, but not µ-opioid receptor signaling, partly mediates the suppression of luteinizing hormone release during late lactation in rats by Tsuchida, Hitomi, Nonogaki, Miku, Inoue, Naoko, Uenoyama, Yoshihisa, Tsukamura, Hiroko

“…•Dynorphin mediates the suppression of LH pulses during late lactation.•β-endorphin-µ-opioid receptor signaling doesn’t mediate the suppression.•PVN and SON…”
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Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator by Nagae, Mayuko, Uenoyama, Yoshihisa, Okamoto, Saki, Tsuchida, Hitomi, Ikegami, Kana, Goto, Teppei, Majarune, Sutisa, Nakamura, Sho, Sanbo, Makoto, Hirabayashi, Masumi, Kobayashi, Kenta, Inoue, Naoko, Tsukamura, Hiroko

“…The gonadotropin-releasing hormone (GnRH) pulse is fundamental for mammalian reproduction: GnRH pulse regimens are needed as therapies for infertile women as…”
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Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats by Tsuchida, Hitomi, Kawai, Narumi, Yamada, Koki, Takizawa, Marina, Inoue, Naoko, Uenoyama, Yoshihisa, Tsukamura, Hiroko

“…Energetic status often affects reproductive function, glucose homeostasis, and feeding in mammals. Malnutrition suppresses pulsatile release of the…”
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Enkephalin-δ Opioid Receptor Signaling Mediates Glucoprivic Suppression of LH Pulse and Gluconeogenesis in Female Rats by Tsuchida, Hitomi, Nonogaki, Miku, Takizawa, Marina, Inoue, Naoko, Uenoyama, Yoshihisa, Tsukamura, Hiroko

“…Abstract Energy availability is an important regulator of reproductive function at various reproductive phases in mammals. Glucoprivation induced by…”
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