An Autopsy Case of Post-COVID-19 Interstitial Lung Disease with Acute Exacerbation

The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Au...

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Bibliographic Details
Published in:	Internal Medicine Vol. 62; no. 23; pp. 3519 - 3523
Main Authors:	Tsuzuku, Akifumi, Asano, Fumihiro, Katayama, Masaki, Mori, Kosuke, Sasaki, Yui, Kuzunishi, Yutaro, Taguchi, Mayuka, Muto, Yuya, Baba, Yasutomo, Tsuchida, Akimasa, Kato, Tomoya, Murakami, Anri, Masuda, Atsunori, Yoshizane, Takashi, Suzuki, Jun
Format:	Journal Article
Language:	English
Published:	Japan The Japanese Society of Internal Medicine 01-12-2023 Japan Science and Technology Agency
Subjects:	Autopsy autopsy pathology Case Report Coronaviruses COVID-19 COVID-19 - complications diffuse alveolar damage Fibrosis Humans Inflammation Internal medicine interstitial lung disease Lung diseases Lung Diseases, Interstitial - complications Lung Diseases, Interstitial - pathology post-COVID-19 post-COVID-19 diffuse alveolar damage interstitial lung disease autopsy pathology
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Summary:	The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Autopsy findings included hyaline membrane formation/interstitial inflammatory cell infiltration, suggestive of acute lesions, and severe regional fibrosis, indicating a preexisting chronic condition. In the present case, we histopathologically confirmed the acute exacerbation of post-COVID-19 interstitial lung disease.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 Correspondence to Dr.　Akifumi Tsuzuku, a.tsuzuku@gmail.com
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.2006-23