Search Results - "Tsubouchi, Asako"

Topological and modality-specific representation of somatosensory information in the fly brain by Tsubouchi, Asako, Yano, Tomoko, Yokoyama, Takeshi K., Murtin, Chloé, Otsuna, Hideo, Ito, Kei

“…Insects and mammals share similarities of neural organization underlying the perception of odors, taste, vision, sound, and gravity. We observed that insect…”
Get full text

Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression by Shiizaki, Kazuhiro, Tsubouchi, Asako, Miura, Yutaka, Seo, Kinya, Kuchimaru, Takahiro, Hayashi, Hirosaka, Iwazu, Yoshitaka, Miura, Marina, Battulga, Batpurev, Ohno, Nobuhiko, Hara, Toru, Kunishige, Rina, Masutani, Mamiko, Negishi, Keita, Kario, Kazuomi, Kotani, Kazuhiko, Yamada, Toshiyuki, Nagata, Daisuke, Komuro, Issei, Itoh, Hiroshi, Kurosu, Hiroshi, Murata, Masayuki, Kuro-O, Makoto

“…The Western pattern diet is rich not only in fat and calories but also in phosphate. The negative effects of excessive fat and calorie intake on health are…”
Get full text

Dendritic Filopodia, Ripped Pocket, NOMPC, and NMDARs Contribute to the Sense of Touch in Drosophila Larvae by Tsubouchi, Asako, Caldwell, Jason C., Tracey, W. Daniel

“…Among the Aristotelian senses, the subcellular and molecular mechanisms involved in the sense of touch are the most poorly understood. We demonstrate that…”
Get full text

In Vivo Fluorescent Adenosine 5′-Triphosphate (ATP) Imaging of Drosophila melanogaster and Caenorhabditis elegans by Using a Genetically Encoded Fluorescent ATP Biosensor Optimized for Low Temperatures by Tsuyama, Taiichi, Kishikawa, Jun-ichi, Han, Yong-Woon, Harada, Yoshie, Tsubouchi, Asako, Noji, Hiroyuki, Kakizuka, Akira, Yokoyama, Ken, Uemura, Tadashi, Imamura, Hiromi

“…Adenosine 5′-triphosphate (ATP) is the major energy currency of all living organisms. Despite its important functions, the spatiotemporal dynamics of ATP…”
Get full text

Homophilic Dscam Interactions Control Complex Dendrite Morphogenesis by Hughes, Michael E., Bortnick, Rachel, Tsubouchi, Asako, Bäumer, Philipp, Kondo, Masahiro, Uemura, Tadashi, Schmucker, Dietmar

“…Alternative splicing of the Drosophila gene Dscam results in up to 38,016 different receptor isoforms proposed to interact by isoform-specific homophilic…”
Get full text

Calciprotein particle-induced cytotoxicity via lysosomal dysfunction and altered cholesterol distribution in renal epithelial HK-2 cells by Kunishige, Rina, Mizoguchi, Mai, Tsubouchi, Asako, Hanaoka, Kenjiro, Miura, Yutaka, Kurosu, Hiroshi, Urano, Yasuteru, Kuro-o, Makoto, Murata, Masayuki

“…Dietary phosphate overload induces chronic kidney disease (CKD), and calciprotein particles (CPPs), a form of nanoparticle comprising calcium phosphate and…”
Get full text

Balboa Binds to Pickpocket In Vivo and Is Required for Mechanical Nociception in Drosophila Larvae by Mauthner, Stephanie E., Hwang, Richard Y., Lewis, Amanda H., Xiao, Qi, Tsubouchi, Asako, Wang, Yu, Honjo, Ken, Skene, J.H. Pate, Grandl, Jörg, Tracey, W. Daniel

“…The Drosophila gene pickpocket (ppk) encodes an ion channel subunit of the degenerin/epithelial sodium channel (DEG/ENaC) family [1]. PPK is specifically…”
Get full text

The Drosophila Small Conductance Calcium-Activated Potassium Channel Negatively Regulates Nociception by Walcott, Kia C.E., Mauthner, Stephanie E., Tsubouchi, Asako, Robertson, Jessica, Tracey, W. Daniel

“…Inhibition of nociceptor activity is important for the prevention of spontaneous pain and hyperalgesia. To identify the critical K+ channels that regulate…”
Get full text

Larval defense against attack from parasitoid wasps requires nociceptive neurons by Robertson, Jessica L, Tsubouchi, Asako, Tracey, W Daniel

“…Parasitoid wasps are a fierce predator of Drosophila larvae. Female Leptopilina boulardi (LB) wasps use a sharp ovipositor to inject eggs into the bodies of…”
Get full text

Localized Suppression of RhoA Activity by Tyr31/118-Phosphorylated Paxillin in Cell Adhesion and Migration by Tsubouchi, Asako, Sakakura, Junko, Yagi, Ryohei, Mazaki, Yuichi, Schaefer, Erik, Yano, Hajime, Sabe, Hisataka

“…RhoA activity is transiently inhibited at the initial phase of integrin engagement, when Cdc42- and/or Rac1-mediated membrane spreading and ruffling…”
Get full text

Mitochondrial protein Preli-like is required for development of dendritic arbors and prevents their regression in the Drosophila sensory nervous system by Tsubouchi, Asako, Tsuyama, Taiichi, Fujioka, Makio, Kohda, Haruyasu, Okamoto-Furuta, Keiko, Aigaki, Toshiro, Uemura, Tadashi

“…Dynamic morphological changes in mitochondria depend on the balance of fusion and fission in various eukaryotes, and are crucial for mitochondrial activity…”
Get full text

An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization by Mazaki, Y, Hashimoto, S, Okawa, K, Tsubouchi, A, Nakamura, K, Yagi, R, Yano, H, Kondo, A, Iwamatsu, A, Mizoguchi, A, Sabe, H

“…Paxillin acts as an adaptor protein in integrin signaling. We have shown that paxillin exists in a relatively large cytoplasmic pool, including perinuclear…”
Get full text

Label-free morphological profiling and isolation of immune cell subsets using VisionSort, a novel, AI-based flow cytometry platform by Schneider, Greg, Wagatsuma, Keisuke, Tsubouchi, Asako, Packiasamy, Juliet, Uematsu, Mika, Nomaru, Hiroko, Teranishi, Kazuki, Akai, Satoru, An, Yuri, Komoriya, Kaoru, Kawamura, Yoko, Ota, Sadao

“…Abstract Identification, characterization, and minimally invasive isolation of specific populations of human immune cells are critical for understanding and…”
Get full text

Label-free morphometric characterization of T cells for cell and gene therapy research and development by Teranishi, Kazuki, Wagatsuma, Keisuke, Uematsu, Mika, Tsubouchi, Asako, An, Yuri, Tamoto, Ryo, Yanagihashi, Yuichi, Kawamura, Yoko, Murata, Yuri, Akai, Satoru, Komoriya, Kaoru, Schneider, Greg, Nomaru, Hiroko, Ota, Sadao

“…Abstract Identification, characterization, and minimally invasive isolation of T cells is critical for developing cellular therapies. Here we used VisionSort,…”
Get full text

Label-Free High Dimensional Single Cell Morphological Profiling of Different Hematological Malignancies By Ghost Cytometry by Tsubouchi, Asako, Miettinen, Juho Jalmari, Wagatsuma, Keisuke, Akai, Satoru, An, Yuri, Uematsu, Mika, Sergeev, Philipp, Tsallos, Dimitrios, Vaha-Koskela, Markus, Ota, Sadao, Heckman, Caroline A.

“…Characterizing the heterogeneity in human leukemias is critical for understanding mechanisms of disease onset, uncovering biomarkers for disease diagnosis, and…”
Get full text

Interaction of Paxillin with p21-activated Kinase (PAK) by Hashimoto, Shigeru, Tsubouchi, Asako, Mazaki, Yuichi, Sabe, Hisataka

“…p21-activated kinases (PAKs) are implicated in integrin signalings, and have been proposed to associate with paxillin indirectly. We show here that paxillin…”
Get full text

Mitochondrial dysfunction induces dendritic loss via eIF2[alpha] phosphorylation by Tsuyama, Taiichi, Tsubouchi, Asako, Usui, Tadao, Imamura, Hiromi, Uemura, Tadashi

“…Mitochondria are key contributors to the etiology of diseases associated with neuromuscular defects or neurodegeneration. How changes in cellular metabolism…”
Get full text

Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation by Tsuyama, Taiichi, Tsubouchi, Asako, Usui, Tadao, Imamura, Hiromi, Uemura, Tadashi

“…Mitochondria are key contributors to the etiology of diseases associated with neuromuscular defects or neurodegeneration. How changes in cellular metabolism…”
Get full text

Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila by Stewart, Andrea, Tsubouchi, Asako, Rolls, Melissa M, Tracey, W Daniel, Sherwood, Nina Tang

“…Dendrite shape is considered a defining component of neuronal function. Yet, the mechanisms specifying diverse dendritic morphologies, and the extent to which…”
Get full text

Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry by Tsubouchi, Asako, An, Yuri, Kawamura, Yoko, Yanagihashi, Yuichi, Nakayama, Hirofumi, Murata, Yuri, Teranishi, Kazuki, Ishiguro, Soh, Aburatani, Hiroyuki, Yachie, Nozomu, Ota, Sadao

“…Recent advancements in image-based pooled CRISPR screening have facilitated the mapping of diverse genotype-phenotype associations within mammalian cells…”
Get full text