Search Results - "Tsuang, M. T."

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction by Ayalew, M, Le-Niculescu, H, Levey, D F, Jain, N, Changala, B, Patel, S D, Winiger, E, Breier, A, Shekhar, A, Amdur, R, Koller, D, Nurnberger, J I, Corvin, A, Geyer, M, Tsuang, M T, Salomon, D, Schork, N J, Fanous, A H, O'Donovan, M C, Niculescu, A B

“…We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia, by gene-level…”
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Neuropsychological performance and family history in children at age 7 who develop adult schizophrenia or bipolar psychosis in the New England Family Studies by Seidman, L J, Cherkerzian, S, Goldstein, J M, Agnew-Blais, J, Tsuang, M T, Buka, S L

“…Persons developing schizophrenia (SCZ) manifest various pre-morbid neuropsychological deficits, studied most often by measures of IQ. Far less is known about…”
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Gene networks specific for innate immunity define post-traumatic stress disorder by Breen, M S, Maihofer, A X, Glatt, S J, Tylee, D S, Chandler, S D, Tsuang, M T, Risbrough, V B, Baker, D G, O'Connor, D T, Nievergelt, C M, Woelk, C H

“…The molecular factors involved in the development of Post-Traumatic Stress Disorder (PTSD) remain poorly understood. Previous transcriptomic studies…”
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Identification of blood biomarkers for psychosis using convergent functional genomics by Kurian, S M, Le-Niculescu, H, Patel, S D, Bertram, D, Davis, J, Dike, C, Yehyawi, N, Lysaker, P, Dustin, J, Caligiuri, M, Lohr, J, Lahiri, D K, Nurnberger, J I, Faraone, S V, Geyer, M A, Tsuang, M T, Schork, N J, Salomon, D R, Niculescu, A B

“…There are to date no objective clinical laboratory blood tests for psychotic disease states. We provide proof of principle for a convergent functional genomics…”
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Prenatal maternal immune disruption and sex-dependent risk for psychoses by Goldstein, J M, Cherkerzian, S, Seidman, L J, Donatelli, J-A L, Remington, A G, Tsuang, M T, Hornig, M, Buka, S L

“…Previous studies suggest that abnormalities in maternal immune activity during pregnancy alter the offspring's brain development and are associated with…”
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A twin study of genetic and environmental influences on suicidality in men by Fu, Q, Heath, A C, Bucholz, K K, Nelson, E C, Glowinski, A L, Goldberg, J, Lyons, M J, Tsuang, M T, Jacob, T, True, M R, Eisen, S A

“…Previous studies that have examined genetic influences on suicidal behaviour were confounded by genetic vulnerability for psychiatric risk factors. The present…”
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A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples by Cohen, O S, Weickert, T W, Hess, J L, Paish, L M, McCoy, S Y, Rothmond, D A, Galletly, C, Liu, D, Weinberg, D D, Huang, X-F, Xu, Q, Shen, Y, Zhang, D, Yue, W, Yan, J, Wang, L, Lu, T, He, L, Shi, Y, Xu, M, Che, R, Tang, W, Chen, C-H, Chang, W-H, Hwu, H-G, Liu, C-M, Liu, Y-L, Wen, C-C, Fann, C S-J, Chang, C-C, Kanazawa, T, Middleton, F A, Duncan, T M, Faraone, S V, Weickert, C S, Tsuang, M T, Glatt, S J

“…The rs1076560 polymorphism of DRD2 (encoding dopamine receptor D2) is associated with alternative splicing and cognitive functioning; however, a mechanistic…”
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Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia by GLATT, S. J, FARAONE, S. V, TSUANG, M. T

“…The D2 subtype of dopamine receptor has been widely implicated in the pathogenesis of schizophrenia. Early evidence supporting an association between the…”
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Longitudinal changes in social cognition in individuals at clinical high risk for psychosis: An outcome based analysis by Shakeel, M.K., Lu, L., Cannon, T.D., Cadenhead, K.S., Cornblatt, B.A., McGlashan, T.H., Perkins, D.O., Seidman, L.J., Tsuang, M.T., Woods, S.W., Walker, E.F., Mathalon, D.H., Bearden, C.E., Addington, J.

“…Social cognition deficits have been observed in individuals at clinical high risk (CHR) for psychosis. Longitudinal change in social cognition were analyzed in…”
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Towards understanding the schizophrenia code: An expanded convergent functional genomics approach by Le-Niculescu, H., Balaraman, Y., Patel, S., Tan, J., Sidhu, K., Jerome, R.E., Edenberg, H.J., Kuczenski, R., Geyer, M.A., Nurnberger Jr, J.I., Faraone, S.V., Tsuang, M.T., Niculescu, A.B.

“…Identifying genes for schizophrenia through classical genetic approaches has proven arduous. Here, we present a comprehensive convergent analysis that…”
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Neuropsychological consequences of regular marijuana use: a twin study by Lyons, M J, Bar, J L, Panizzon, M S, Toomey, R, Eisen, S, Xian, H, Tsuang, M T

“…Results of previous research examining long-term residual effects of marijuana use on cognition are conflicting. A major methodological limitation of prior…”
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Phenomic, Convergent Functional Genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism by Le-Niculescu, H., McFarland, M.J., Ogden, C.A., Balaraman, Y., Patel, S., Tan, J., Rodd, Z.A., Paulus, M., Geyer, M.A., Edenberg, H.J., Glatt, S.J., Faraone, S.V., Nurnberger, J.I., Kuczenski, R., Tsuang, M.T., Niculescu, A.B.

“…We had previously identified the clock gene D‐box binding protein (Dbp) as a potential candidate gene for bipolar disorder and for alcoholism, using a…”
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Toward Reformulating the Diagnosis of Schizophrenia by Tsuang, Ming T., Stone, William S., Faraone, Stephen V.

“…OBJECTIVE: The authors assess implications of DSM criteria for schizophrenia by reviewing the criteria's 1) emphasis on psychotic features, 2) dissociation of…”
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Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men by PANIZZON, M. S, HAUGER, R, JACOBSON, K. C, LYONS, M. J, MENDOZA, S. P, NEALE, M. C, PROM-WORMLEY, E. C, SEIDMAN, L. J, TSUANG, M. T, XIAN, H, KREMEN, W. S, DALE, A. M, EAVES, L. J, EYLER, L. T, FISCHL, B, FENNEMA-NOTESTINE, C, FRANZ, C. E, GRANT, M. D, JAK, A. J

“…The APOE epsilon4 allele is an established risk factor for Alzheimer disease (AD), yet findings are mixed for how early its effects are manifest. One reason…”
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Identifying blood biomarkers for mood disorders using convergent functional genomics by Le-Niculescu, H, Kurian, S M, Yehyawi, N, Dike, C, Patel, S D, Edenberg, H J, Tsuang, M T, Salomon, D R, Nurnberger, J I, Niculescu, A B

“…There are to date no objective clinical laboratory blood tests for mood disorders. The current reliance on patient self-report of symptom severity and on the…”
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Genes, environment and schizophrenia by Tsuang, Ming T., Stone, William S., Faraone, Stephen V.

“…Data from family, twin and adoption studies show overwhelming evidence of a substantial genetic component in schizophrenia and although molecular genetic…”
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Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan by Glatt, S J, Faraone, S V, Lasky-Su, J A, Kanazawa, T, Hwu, H-G, Tsuang, M T

“…The gene that codes for dopamine receptor D2 ( DRD2 on chromosome 11q23) has long been a prime functional and positional candidate risk gene for schizophrenia…”
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More evidence supports the association of PPP3CC with schizophrenia by LIU, Y. L, FANN, C. S. J, TSUANG, M. M, WU, J. Y, JOU, Y. S, FARAONE, S. V, TSUANG, M. T, CHEN, W. J, WU, H-G. H, LIU, C. M, CHANG, C. C, YANG, W. C, HUNG, S. L, YU, S. L, HWANG, T. J, HSIEH, M. H, LIU, C. C

“…Calcineurin is a calcium/calmodulin-dependent protein phosphatase composed of two subunits, a regulatory subunit of calcineurin B (CNB) and a catalytic subunit…”
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Educational attainment, smoking initiation and lifetime nicotine dependence among male Vietnam-era twins by McCaffery, J M, Papandonatos, G D, Lyons, M J, Koenen, K C, Tsuang, M T, Niaura, R

“…Smoking initiation and persistence are clearly associated with factors commonly thought to be environmental in origin, including socio-economic status…”
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Family study of the aggregation of eating disorders and mood disorders by Mangweth, B, Hudson, J I, Pope, H G, Hausmann, A, De Col, C, Laird, N M, Beibl, W, Tsuang, M T

“…Family studies have suggested that eating disorders and mood disorders may coaggregate in families. To study further this question, data from a family…”
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