Search Results - "Tsuang, Debby W."

Review Article: Genetics of Alzheimer Disease by Bekris, Lynn M., Yu, Chang-En, Bird, Thomas D., Tsuang, Debby W.

“…Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with…”
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Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study by Greenwood, Tiffany A, Lazzeroni, Laura C, Maihofer, Adam X, Swerdlow, Neal R, Calkins, Monica E, Freedman, Robert, Green, Michael F, Light, Gregory A, Nievergelt, Caroline M, Nuechterlein, Keith H, Radant, Allen D, Siever, Larry J, Silverman, Jeremy M, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Gur, Ruben C, Gur, Raquel E, Braff, David L

“…The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative neurophysiological and neurocognitive endophenotypes with demonstrated deficits in…”
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Detection of probable dementia cases in undiagnosed patients using structured and unstructured electronic health records by Shao, Yijun, Zeng, Qing T, Chen, Kathryn K, Shutes-David, Andrew, Thielke, Stephen M, Tsuang, Debby W

“…Dementia is underdiagnosed in both the general population and among Veterans. This underdiagnosis decreases quality of life, reduces opportunities for…”
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Support for the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families by Timms, Andrew E, Dorschner, Michael O, Wechsler, Jeremy, Choi, Kyu Yeong, Kirkwood, Robert, Girirajan, Santhosh, Baker, Carl, Eichler, Evan E, Korvatska, Olena, Roche, Katherine W, Horwitz, Marshall S, Tsuang, Debby W

“…Schizophrenia is a complex genetic disorder demonstrating considerable heritability. Genetic studies have implicated many different genes and pathways, but…”
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Validation of mismatch negativity and P3a for use in multi-site studies of schizophrenia: Characterization of demographic, clinical, cognitive, and functional correlates in COGS-2 by Light, Gregory A, Swerdlow, Neal R, Thomas, Michael L, Calkins, Monica E, Green, Michael F, Greenwood, Tiffany A, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Nuechterlein, Keith H, Pela, Marlena, Radant, Allen D, Seidman, Larry J, Sharp, Richard F, Siever, Larry J, Silverman, Jeremy M, Sprock, Joyce, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Braff, David L, Turetsky, Bruce I

“…Abstract Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and…”
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Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension by Swerdlow, Neal R., Light, Gregory A., Thomas, Michael L., Sprock, Joyce, Calkins, Monica E., Green, Michael F., Greenwood, Tiffany A., Gur, Raquel E., Gur, Ruben C., Lazzeroni, Laura C., Nuechterlein, Keith H., Radant, Allen D., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Sugar, Catherine A., Tsuang, Debby W., Tsuang, Ming T., Turetsky, Bruce I., Braff, David L.

“…The Consortium on the Genetics of Schizophrenia (COGS) collected case-control endophenotype and genetic information from 2457 patients and healthy subjects…”
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Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases by Nakashima-Yasuda, Hanae, Uryu, Kunihiro, Robinson, John, Xie, Sharon X, Hurtig, Howard, Duda, John E, Arnold, Steven E, Siderowf, Andrew, Grossman, Murray, Leverenz, James B, Woltjer, Randy, Lopez, Oscar L, Hamilton, Ronald, Tsuang, Debby W, Galasko, Douglas, Masliah, Eliezer, Kaye, Jeffrey, Clark, Christopher M, Montine, Thomas J, Lee, Virginia M-Y, Trojanowski, John Q

“…Here, we investigated if TAR-DNA-binding protein-43 (TDP-43), the disease protein in frontotemporal lobar degeneration and ubiquitin inclusions with or without…”
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Deficient prepulse inhibition in schizophrenia detected by the multi-site COGS by Swerdlow, Neal R, Light, Gregory A, Sprock, Joyce, Calkins, Monica E, Green, Michael F, Greenwood, Tiffany A, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Nuechterlein, Keith H, Radant, Allen D, Ray, Amrita, Seidman, Larry J, Siever, Larry J, Silverman, Jeremy M, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Braff, David L

“…Abstract Background Startle inhibition by weak prepulses (PPI) is studied to understand the biology of information processing in schizophrenia patients and…”
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Proteomic Identification of Novel Proteins in Cortical Lewy Bodies by Leverenz, James B., Umar, Imran, Wang, Qing, Montine, Thomas J., McMillan, Pamela J., Tsuang, Debby W., Jin, Jinghua, Pan, Catherine, Shin, Jenny, Zhu, David, Zhang, Jing

“…Lewy body (LB) inclusions are one of the pathological hallmarks of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). One way to better understand…”
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Identifying Probable Dementia in Undiagnosed Black and White Americans Using Machine Learning in Veterans Health Administration Electronic Health Records by Shao, Yijun, Todd, Kaitlin, Shutes-David, Andrew, Millard, Steven P, Brown, Karl, Thomas, Amy, Chen, Kathryn, Wilson, Katherine, Zeng, Qing T, Tsuang, Debby W

“…The application of natural language processing and machine learning (ML) in electronic health records (EHRs) may help reduce dementia underdiagnosis, but…”
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Neurocognitive performance in family-based and case-control studies of schizophrenia by Gur, Ruben C, Braff, David L, Calkins, Monica E, Dobie, Dorcas J, Freedman, Robert, Green, Michael F, Greenwood, Tiffany A, Lazzeroni, Laura C, Light, Gregory A, Nuechterlein, Keith H, Olincy, Ann, Radant, Allen D, Seidman, Larry J, Siever, Larry J, Silverman, Jeremy M, Sprock, Joyce, Stone, William S, Sugar, Catherine A, Swerdlow, Neal R, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Gur, Raquel E

“…Abstract Background Neurocognitive deficits in schizophrenia (SZ) are established and the Consortium on the Genetics of Schizophrenia (COGS) investigated such…”
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Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: Patterns of linkage disequilibrium and disease/marker association by Yu, Chang-En, Seltman, Howard, Peskind, Elaine R., Galloway, Nichole, Zhou, Peter X., Rosenthal, Elisabeth, Wijsman, Ellen M., Tsuang, Debby W., Devlin, Bernie, Schellenberg, Gerard D.

“…The ε 4 allele of APOE confers a two- to fourfold increased risk for late-onset Alzheimer’s disease (LOAD), but LOAD pathology does not all fit neatly around…”
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The effect of algorithms on copy number variant detection by Tsuang, Debby W, Millard, Steven P, Ely, Benjamin, Chi, Peter, Wang, Kenneth, Raskind, Wendy H, Kim, Sulgi, Brkanac, Zoran, Yu, Chang-En

“…The detection of copy number variants (CNVs) and the results of CNV-disease association studies rely on how CNVs are defined, and because array-based…”
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Genetics of Alzheimer disease by Bekris, Lynn M, Yu, Chang-En, Bird, Thomas D, Tsuang, Debby W

“…Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with…”
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Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease by Bekris, Lynn M., Millard, Steve, Lutz, Franziska, Li, Gail, Galasko, Doug R., Farlow, Martin R., Quinn, Joseph F., Kaye, Jeffrey A., Leverenz, James B., Tsuang, Debby W., Yu, Chang-En, Peskind, Elaine R.

“…Alzheimer's disease (AD) is characterized by the presence in the brain of amyloid plaques, consisting predominately of the amyloid β peptide (Aβ), and…”
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Anticholinergic Medication Burden–Associated Cognitive Impairment in Schizophrenia by Joshi, Yash B, Thomas, Michael L, Braff, David L, Green, Michael F, Gur, Ruben C, Gur, Raquel E, Nuechterlein, Keith H, Stone, William S, Greenwood, Tiffany A, Lazzeroni, Laura C, MacDonald, Laura R, Molina, Juan L, Nungaray, John A, Radant, Allen D, Silverman, Jeremy M, Sprock, Joyce, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Swerdlow, Neal R, Light, Gregory A

“…Objective:Many psychotropic medications used to treat schizophrenia have significant anticholinergic properties, which are linked to cognitive impairment and…”
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Modeling Deficits From Early Auditory Information Processing to Psychosocial Functioning in Schizophrenia by Thomas, Michael L, Green, Michael F, Hellemann, Gerhard, Sugar, Catherine A, Tarasenko, Melissa, Calkins, Monica E, Greenwood, Tiffany A, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Nuechterlein, Keith H, Radant, Allen D, Seidman, Larry J, Shiluk, Alexandra L, Siever, Larry J, Silverman, Jeremy M, Sprock, Joyce, Stone, William S, Swerdlow, Neal R, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Braff, David L, Light, Gregory A

“…Neurophysiologic measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clinical intervention…”
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Alzheimer's Disease and Alzheimer's Disease-Related Dementias in Older African American and White Veterans by Cheng, Yan, Ahmed, Ali, Zamrini, Edward, Tsuang, Debby W, Sheriff, Helen M, Zeng-Treitler, Qing

“…Racial disparity in the epidemiology of Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) has been reported. However, less is known about…”
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Evolution of a Human-Specific Tandem Repeat Associated with ALS by Course, Meredith M., Gudsnuk, Kathryn, Smukowski, Samuel N., Winston, Kosuke, Desai, Nitin, Ross, Jay P., Sulovari, Arvis, Bourassa, Cynthia V., Spiegelman, Dan, Couthouis, Julien, Yu, Chang-En, Tsuang, Debby W., Jayadev, Suman, Kay, Mark A., Gitler, Aaron D., Dupre, Nicolas, Eichler, Evan E., Dion, Patrick A., Rouleau, Guy A., Valdmanis, Paul N.

“…Tandem repeats are proposed to contribute to human-specific traits, and more than 40 tandem repeat expansions are known to cause neurological disease. Here, we…”
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Association of CSF α-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy Bodies by Coughlin, David G, MacLeod, Karen R, Middleton, John S, Bozoki, Andrea C, Galvin, James E, Irwin, David J, Lippa, Carol F, Litvan, Irene, Lopez, Oscar L, Berman, Sarah, Tsuang, Debby W, Zabetian, Cyrus P, Honig, Lawrence S, Marder, Karen S, Fleisher, Jori E, Sabbagh, Marwan, Wint, Dylan, Taylor, Angela S, Bekris, Lynn, Leverenz, James B, Galasko, Douglas

“…The clinical diagnosis of dementia with Lewy bodies (DLB) depends on identifying significant cognitive decline accompanied by core features of parkinsonism,…”
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