Search Results - "Tsuang, Debby"

Review Article: Genetics of Alzheimer Disease by Bekris, Lynn M., Yu, Chang-En, Bird, Thomas D., Tsuang, Debby W.

“…Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with…”
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Genetics of Alzheimer disease by Bekris, Lynn M, Yu, Chang-En, Bird, Thomas D, Tsuang, Debby W

“…Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with…”
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Anticholinergic Medication Burden–Associated Cognitive Impairment in Schizophrenia by Joshi, Yash B, Thomas, Michael L, Braff, David L, Green, Michael F, Gur, Ruben C, Gur, Raquel E, Nuechterlein, Keith H, Stone, William S, Greenwood, Tiffany A, Lazzeroni, Laura C, MacDonald, Laura R, Molina, Juan L, Nungaray, John A, Radant, Allen D, Silverman, Jeremy M, Sprock, Joyce, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Swerdlow, Neal R, Light, Gregory A

“…Objective:Many psychotropic medications used to treat schizophrenia have significant anticholinergic properties, which are linked to cognitive impairment and…”
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Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study by Greenwood, Tiffany A, Lazzeroni, Laura C, Maihofer, Adam X, Swerdlow, Neal R, Calkins, Monica E, Freedman, Robert, Green, Michael F, Light, Gregory A, Nievergelt, Caroline M, Nuechterlein, Keith H, Radant, Allen D, Siever, Larry J, Silverman, Jeremy M, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Gur, Ruben C, Gur, Raquel E, Braff, David L

“…The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative neurophysiological and neurocognitive endophenotypes with demonstrated deficits in…”
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Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network by Gulsuner, Suleyman, Walsh, Tom, Watts, Amanda C., Lee, Ming K., Thornton, Anne M., Casadei, Silvia, Rippey, Caitlin, Shahin, Hashem, Braff, David, Cadenhead, Kristin S., Calkins, Monica E., Dobie, Dorcas J., Freedman, Robert, Green, Michael, Greenwood, Tiffany, Gur, Raquel E., Gur, Ruben C., Lazzeroni, Laura, Light, Gregory, Nuechterlein, Keith, Olincy, Ann, Radant, Al, Ray, Amrita, Schork, Nik, Seidman, Larry J., Siever, Larry, Silverman, Jeremy, Stone, William S., Sugar, Catherine, Swerdlow, Neal, Tsuang, Debby, Tsuang, Ming, Turetsky, Bruce, Aduroja, Tolulope, Allen, Trina, Bradford, L. Diane, Calkins, Monica E., Devlin, Bernie, Edwards, Neil B., Ganguli, Rohan, Go, Rodney C.P., Gur, Raquel E., Gur, Ruben C., Kwentus, Joseph, Lahti, Adrienne C., Lyons, Paul, Mathos, Kim, May, Roberta, McLeod-Bryant, Steve, McEvoy, Joseph P., Montgomery-Barefield, Laura, Nimgaonkar, Vishwajit L., O’Jile, Judith, Santos, Al, Savage, Robert M., Swanson, Charles L., Wilson, William, Nimgaonkar, Vishwajit L., Go, Rodney C.P., Savage, Robert M., Swerdlow, Neal R., Gur, Raquel E., Braff, David L., King, Mary-Claire, McClellan, Jon M.

“…Genes disrupted in schizophrenia may be revealed by de novo mutations in affected persons from otherwise healthy families. Furthermore, during normal brain…”
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Detection of probable dementia cases in undiagnosed patients using structured and unstructured electronic health records by Shao, Yijun, Zeng, Qing T, Chen, Kathryn K, Shutes-David, Andrew, Thielke, Stephen M, Tsuang, Debby W

“…Dementia is underdiagnosed in both the general population and among Veterans. This underdiagnosis decreases quality of life, reduces opportunities for…”
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Support for the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families by Timms, Andrew E, Dorschner, Michael O, Wechsler, Jeremy, Choi, Kyu Yeong, Kirkwood, Robert, Girirajan, Santhosh, Baker, Carl, Eichler, Evan E, Korvatska, Olena, Roche, Katherine W, Horwitz, Marshall S, Tsuang, Debby W

“…Schizophrenia is a complex genetic disorder demonstrating considerable heritability. Genetic studies have implicated many different genes and pathways, but…”
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Validation of mismatch negativity and P3a for use in multi-site studies of schizophrenia: Characterization of demographic, clinical, cognitive, and functional correlates in COGS-2 by Light, Gregory A, Swerdlow, Neal R, Thomas, Michael L, Calkins, Monica E, Green, Michael F, Greenwood, Tiffany A, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Nuechterlein, Keith H, Pela, Marlena, Radant, Allen D, Seidman, Larry J, Sharp, Richard F, Siever, Larry J, Silverman, Jeremy M, Sprock, Joyce, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Braff, David L, Turetsky, Bruce I

“…Abstract Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and…”
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Alzheimer's Disease and Alzheimer's Disease-Related Dementias in Older African American and White Veterans by Cheng, Yan, Ahmed, Ali, Zamrini, Edward, Tsuang, Debby W, Sheriff, Helen M, Zeng-Treitler, Qing

“…Racial disparity in the epidemiology of Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) has been reported. However, less is known about…”
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Criteria for Psychosis in Major and Mild Neurocognitive Disorders: International Psychogeriatric Association (IPA) Consensus Clinical and Research Definition by Cummings, Jeffrey, Pinto, Luiz Cortez, Cruz, Manuel, Fischer, Corinne E., Gerritsen, Debby L., Grossberg, George T., Hwang, Tzung-Jeng, Ismail, Zahinoor, Jeste, Dilip V., Koopmans, Raymond, Lanctot, Krista L., Mateos, Raimundo, Peschin, Susan, Sampaio, Cristina, Tsuang, Debby, Wang, Huali, Zhong, Kate, Bain, Lisa J., Sano, Mary

“…•Criteria for psychosis in dementia have not been reviewed and revised for twenty years; new knowledge informed a process led by the International…”
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Evolution of a Human-Specific Tandem Repeat Associated with ALS by Course, Meredith M., Gudsnuk, Kathryn, Smukowski, Samuel N., Winston, Kosuke, Desai, Nitin, Ross, Jay P., Sulovari, Arvis, Bourassa, Cynthia V., Spiegelman, Dan, Couthouis, Julien, Yu, Chang-En, Tsuang, Debby W., Jayadev, Suman, Kay, Mark A., Gitler, Aaron D., Dupre, Nicolas, Eichler, Evan E., Dion, Patrick A., Rouleau, Guy A., Valdmanis, Paul N.

“…Tandem repeats are proposed to contribute to human-specific traits, and more than 40 tandem repeat expansions are known to cause neurological disease. Here, we…”
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Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension by Swerdlow, Neal R., Light, Gregory A., Thomas, Michael L., Sprock, Joyce, Calkins, Monica E., Green, Michael F., Greenwood, Tiffany A., Gur, Raquel E., Gur, Ruben C., Lazzeroni, Laura C., Nuechterlein, Keith H., Radant, Allen D., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Sugar, Catherine A., Tsuang, Debby W., Tsuang, Ming T., Turetsky, Bruce I., Braff, David L.

“…The Consortium on the Genetics of Schizophrenia (COGS) collected case-control endophenotype and genetic information from 2457 patients and healthy subjects…”
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Association of CSF α-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy Bodies by Coughlin, David G, MacLeod, Karen R, Middleton, John S, Bozoki, Andrea C, Galvin, James E, Irwin, David J, Lippa, Carol F, Litvan, Irene, Lopez, Oscar L, Berman, Sarah, Tsuang, Debby W, Zabetian, Cyrus P, Honig, Lawrence S, Marder, Karen S, Fleisher, Jori E, Sabbagh, Marwan, Wint, Dylan, Taylor, Angela S, Bekris, Lynn, Leverenz, James B, Galasko, Douglas

“…The clinical diagnosis of dementia with Lewy bodies (DLB) depends on identifying significant cognitive decline accompanied by core features of parkinsonism,…”
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Sensitivity of Schizophrenia Endophenotype Biomarkers to Anticholinergic Medication Burden by Joshi, Yash B, Molina, Juan L, Braff, David L, Green, Michael F, Gur, Ruben C, Gur, Raquel E, Nuechterlein, Keith H, Stone, William S, Greenwood, Tiffany A, Lazzeroni, Laura C, Radant, Allen D, Silverman, Jeremy M, Sprock, Joyce, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Swerdlow, Neal R, Light, Gregory A

“…While schizophrenia is characterized by generalized cognitive deficits across the course of illness. emerging evidence suggests many medications can also…”
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Mild disease course in cognitively impaired oldest old individuals with COVID‐19: A description of two cases by Tsuang, Debby W., Payne, Sarah, Jankowski, Adrienne, Shutes‐David, Andrew, Ritchey, Katherine

“…Background The COVID‐19 pandemic has swept across the world, causing a staggering number of deaths, particularly among older individuals. The most common…”
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Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases by Nakashima-Yasuda, Hanae, Uryu, Kunihiro, Robinson, John, Xie, Sharon X, Hurtig, Howard, Duda, John E, Arnold, Steven E, Siderowf, Andrew, Grossman, Murray, Leverenz, James B, Woltjer, Randy, Lopez, Oscar L, Hamilton, Ronald, Tsuang, Debby W, Galasko, Douglas, Masliah, Eliezer, Kaye, Jeffrey, Clark, Christopher M, Montine, Thomas J, Lee, Virginia M-Y, Trojanowski, John Q

“…Here, we investigated if TAR-DNA-binding protein-43 (TDP-43), the disease protein in frontotemporal lobar degeneration and ubiquitin inclusions with or without…”
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Homozygous CADPS2 Mutations Cause Neurodegenerative Disease with Lewy Body‐like Pathology in Parrots by Lorenzo‐Betancor, Oswaldo, Galosi, Livio, Bonfili, Laura, Eleuteri, Anna Maria, Cecarini, Valentina, Verin, Ranieri, Dini, Fabrizio, Attili, Anna‐Rita, Berardi, Sara, Biagini, Lucia, Robino, Patrizia, Stella, Maria Cristina, Yearout, Dora, Dorschner, Michael O., Tsuang, Debby W., Rossi, Giacomo, Zabetian, Cyrus P.

“…Background Several genetic models that recapitulate neurodegenerative features of Parkinson's disease (PD) exist, which have been largely based on genes…”
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The utility of P300 as a schizophrenia endophenotype and predictive biomarker: Clinical and socio-demographic modulators in COGS-2 by Turetsky, Bruce I, Dress, Erich M, Braff, David L, Calkins, Monica E, Green, Michael F, Greenwood, Tiffany A, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Nuechterlein, Keith H, Radant, Allen D, Seidman, Larry J, Siever, Larry J, Silverman, Jeremy M, Sprock, Joyce, Stone, William S, Sugar, Catherine A, Swerdlow, Neal R, Tsuang, Debby W, Tsuang, Ming T, Light, Gregory

“…Abstract Reduced auditory P300 amplitude is a robust schizophrenia deficit exhibiting the qualities of a viable genetic endophenotype. These include…”
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Genetic factors in neurodegenerative diseases by Tsuang, Debby W., Bird, Thomas D.

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Deficient prepulse inhibition in schizophrenia detected by the multi-site COGS by Swerdlow, Neal R, Light, Gregory A, Sprock, Joyce, Calkins, Monica E, Green, Michael F, Greenwood, Tiffany A, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Nuechterlein, Keith H, Radant, Allen D, Ray, Amrita, Seidman, Larry J, Siever, Larry J, Silverman, Jeremy M, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Braff, David L

“…Abstract Background Startle inhibition by weak prepulses (PPI) is studied to understand the biology of information processing in schizophrenia patients and…”
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