Search Results - "Tsoukas, Christos M"

Good's Syndrome: Time to Move on From Reviewing the Past by Kabir, Aunonna, Alizadehfar, Reza, Tsoukas, Christos M

“…For seven decades, the pathophysiology of Good's syndrome (GS) has remained a mystery, with few attempts to solve it. Initially described as an association…”
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Comprehensive evaluation of the immune risk phenotype in successfully treated HIV-infected individuals by Ndumbi, Patricia, Gilbert, Louise, Tsoukas, Christos M

“…Despite successful treatment and CD4+ T-cell recovery, HIV-infected individuals often experience a profound immune dysregulation characterized by a…”
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Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals by Boulet, Salix, Sharafi, Saeid, Simic, Nancy, Bruneau, Julie, Routy, Jean-Pierre, Tsoukas, Christos M, Bernard, Nicole F

“…Natural killer (NK) cell activity is increased in individuals who remain uninfected despite repeated exposures to HIV. Given that a combined major…”
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Delay in cART initiation results in persistent immune dysregulation and poor recovery of T-cell phenotype despite a decade of successful HIV suppression by Ndumbi, Patricia, Falutz, Julian, Pant Pai, Nitika, Tsoukas, Christos M

“…Successful combination antiretroviral therapy (cART) increases levels of CD4+ T-cells, however this increase may not accurately reflect long-term immune…”
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Receptor-Ligand Requirements for Increased NK Cell Polyfunctional Potential in Slow Progressors Infected with HIV-1 Coexpressing KIR3DL1h/y and HLA-B57 by KAMYA, Philomena, BOULET, Salix, CONNORS, Mark, SUSCOVICH, Todd J, BRANDER, Christian, TREMBLAY, Cecile L, BERNARD, Nicole, TSOUKAS, Christos M, ROUTY, Jean-Pierre, THOMAS, Rejean, COTE, Pierre, BOULASSEL, Mohamed-Rachid, BARIL, Jean-Guy, KOVACS, Colin, MIGUELES, Stephen A

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Time to seroconversion in HIV-exposed subjects carrying protective versus non protective KIR3DS1/L1 and HLA-B genotypes by Tallon, Benjamin J M, Bruneau, Julie, Tsoukas, Christos M, Routy, Jean-Pierre, Kiani, Zahra, Tan, Xianming, Bernard, Nicole F

“…Natural killer (NK) cells play a role in the clearance of viral infections. Combinations of alleles at the polymorphic HLA-B locus and the NK cell surface…”
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HIV exposed seronegative (HESN) compared to HIV infected individuals have higher frequencies of telomeric Killer Immunoglobulin-like Receptor (KIR) B motifs; Contribution of KIR B motif encoded genes to NK cell responsiveness by Jackson, Elise, Zhang, Cindy Xinyu, Kiani, Zahra, Lisovsky, Irene, Tallon, Benjamin, Del Corpo, Alexa, Gilbert, Louise, Bruneau, Julie, Thomas, Réjean, Côté, Pierre, Trottier, Benoit, LeBlanc, Roger, Rouleau, Danielle, Tremblay, Cécile, Tsoukas, Christos M, Routy, Jean-Pierre, Ni, Xiaoyan, Mabanga, Tsoarello, Bernard, Nicole F

“…Previously, we showed that Killer Immunoglobulin-like Receptor (KIR)3DS1 homozygotes (hmz) are more frequent in HIV exposed seronegative (HESN) than in…”
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Mind the Gap: Lack of Association between KIR3DL1004/HLA-Bw4—Induced Natural Killer Cell Function and Protection from HIV Infection by Parsons, Matthew S., Boulet, Salix, Song, Rujun, Bruneau, Julie, Shoukry, Naglaa H., Routy, Jean-Pierre, Tsoukas, Christos M., Bernard, Nicole F.

“…Several combinations of genes encoding KIR3DL1 alleles and their HLA-Bw4 ligands have been linked with favorable outcomes upon exposure to or infection with…”
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Are the Healthy Vulnerable? Cytomegalovirus Seropositivity in Healthy Adults Is Associated With Accelerated Epigenetic Age and Immune Dysregulation by Poloni, Chad, Szyf, Moshe, Cheishvili, David, Tsoukas, Christos M

“…Abstract Background Evaluating age as a risk factor for susceptibility to infectious diseases, particularly coronavirus disease 2019 (COVID-19), is critical…”
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Unraveling the Natural History of Good’s Syndrome: A Progressive Adult Combined Immunodeficiency by Kabir, Aunonna, Polito, Vanessa, Tsoukas, Christos M.

“…Good’s syndrome (GS) is a rare immune deficiency described almost 6 decades ago. Despite numerous published individual case reports and data collected in…”
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Hepatitis C Virus Is Related to Progressive Liver Disease in Human Immunodeficiency Virus—Positive Hemophiliacs and Should Be Treated as an Opportunistic Infection by Lesens, Olivier, Deschênes, Marc, Steben, Marc, Bélanger, Gisèle, Tsoukas, Christos M.

“…The hypothesis was investigated that hepatitis C virus (HCV) infection behaves like an opportunistic infection in which progressive liver disease (PLD) is the…”
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Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point by Alsulami, Khlood, Bolastig, Naomi, Dupuy, Franck P, Mabanga, Tsoarello, Gilbert, Louise, Kiani, Zahra, Routy, Jean-Pierre, Bruneau, Julie, Thomas, Réjean, Tremblay, Cécile, Tsoukas, Christos M, Szabo, Jason, Côté, Pierre, Trottier, Benoit, LeBlanc, Roger, Rouleau, Danielle, Bernard, Nicole F

“…NKG2C is an activating NK cell receptor encoded by a gene having an unexpressed deletion variant. Cytomegalovirus (CMV) infection expands a population of NKG2C…”
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HIV Protective KIR3DL1 and HLA-B Genotypes Influence NK Cell Function Following Stimulation with HLA-Devoid Cells by Boulet, Salix, Song, Rujun, Kamya, Philomena, Bruneau, Julie, Shoukry, Naglaa H, Tsoukas, Christos M, Bernard, Nicole F

“…Epidemiological studies in humans have implicated carriage of combinations of genes encoding certain KIR3DL1 (killer Ig-like receptor 3DL1) alleles and their…”
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T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers by Kamya, Philomena, Tsoukas, Christos M, Boulet, Salix, Routy, Jean-Pierre, Thomas, Réjean, Côté, Pierre, Boulassel, Mohamed-Rachid, Lessard, Bernard, Kaul, Rupert, Ostrowski, Mario, Kovacs, Colin, Tremblay, Cecile L, Bernard, Nicole F

“…Elite controllers (EC) are a rare subset of HIV infected individuals who control viral load below 50 copies/ml of plasma without treatment. Thirty four EC were…”
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Human Immunodeficiency Virus (HIV)-Specific Gamma Interferon Secretion Directed against All Expressed HIV Genes: Relationship to Rate of CD4 Decline by PERETZ, Yoav, ALTER, Galit, BOISVERT, Marie-Pierre, HATZAKIS, George, TSOUKAS, Christos M, BERNARD, Nicole F

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Human Immunodeficiency Virus (HIV)—Specific Cytotoxic T Lymphocyte Activity in HIV-Exposed Seronegative Persons by Bernard, Nicole F., Yannakis, Christina M., Lee, Jimmy S., Tsoukas, Christos M.

“…Repeated exposure to human immunodeficiency virus (HIV) does not always result in seroconversion. Understanding the conditions that permit or protect against…”
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Relative contribution of HIV-specific functional lymphocyte subsets restricted by protective and non-protective HLA alleles by Peretz, Yoav, Marra, Olivia, Thomas, Réjean, Legault, Danielle, Côté, Pierre, Boulassel, Mohamed-Rachid, Rouleau, Danielle, Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Tsoukas, Christos M, Tremblay, Cécile, Bernard, Nicole F

“…Expression of major histocompatibility complex (MHC) class I alleles such as B*57 and B*27 are associated with slow HIV disease progression. HIV-specific…”
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A combined genotype of KIR3DL1 high expressing alleles and HLA-B57 is associated with a reduced risk of HIV infection by BOULET, Salix, KLEYMAN, Marianna, KIM, Jenice Y. J, KAMYA, Philomena, SHARAFI, Saeid, SIMIC, Nancy, BRUNEAU, Julie, ROUTY, Jean-Pierre, TSOUKAS, Christos M, BERNARD, Nicole F

“…Coexpression of certain combinations of natural killer cell receptor KIR3DL1 and HLA-B alleles is associated with slower time to AIDS. The strongest protection…”
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Adult Primary Immune Deficiency: What Are We Missing? by Srinivasa, Bharat T, Alizadehfar, Reza, Desrosiers, Martin, Shuster, Joseph, Pai, Nitika Pant, Tsoukas, Christos M

“…Abstract Background More than 200 primary immune deficiencies have been described. In adults, their identification can be difficult. The lack of timely…”
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Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption by Huang, Kenneth H, Loutfy, Mona R, Tsoukas, Christos M, Bernard, Nicole F

“…The advantage of treatment interruptions (TIs) in salvage therapy remains controversial. Regardless, characterizations of the correlates of CD4 count fall…”
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