Search Results - "Tsopanoglou, Nikos"

Combined Treatment With Exenatide and Cyclosporine A or Parstatin 1-26 Results in Enhanced Reduction of Infarct Size in a Rabbit Model by Alexopoulos, Panagiotis, Panoutsopoulou, Konstantina, Vogiatzis, George, Koletsis, Efstratios, Dougenis, Dimitrios, Tsopanoglou, Nikos E

“…Exenatide and cyclosporine A have been shown to moderately protect against myocardial reperfusion injury leading to reduction of infarct size in patients. Our…”
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The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression by Zampatis, Dimitris E., Rutz, Claudia, Furkert, Jens, Schmidt, Antje, Wüstenhagen, Doreen, Kubick, Stefan, Tsopanoglou, Nikos E., Schülein, Ralf

“…► We show that the PAR1 possesses a functional and cleaved signal peptide at its N terminus. ► We show that the sequence encoding the signal peptide of the…”
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Parstatin(1-26): the putative signal peptide of protease-activated receptor 1 confers potent protection from myocardial ischemia-reperfusion injury by Routhu, Kasi V, Tsopanoglou, Nikos E, Strande, Jennifer L

“…Parstatin, the N-terminal 41-amino-acid peptide cleaved by thrombin from the protease-activated receptor 1, protects against rat myocardial ischemia and…”
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NGF Promotes Hemodynamic Recovery in a Rabbit Hindlimb Ischemic Model Through trkA- and VEGFR2-dependent Pathways by Karatzas, Andreas, Katsanos, Konstantinos, Lilis, Ioannis, Papadaki, Helen, Kitrou, Panagiotis, Lecht, Shimon, Marcinkiewicz, Cezary, Siablis, Dimitris, Lelkes, Peter I., Lazarovici, Philip, Tsopanoglou, Nikos E.

“…Nerve growth factor (NGF) has been reported to play an important role in physiological and pathological angiogenesis. Based on these observations, we…”
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Inhibition of angiogenesis by small-molecule antagonists of protease-activated receptor-1 by Tsopanoglou, Nikos E, Maragoudakis, Michael E

“…Angiogenesis, the growth of new blood vessels from preexisting ones, is a necessary component of embryogenesis, wound healing, and the proliferative phase of…”
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Thrombin's central role in angiogenesis and pathophysiological processes by Tsopanoglou, Nikos E, Maragoudakis, Michael E

“…A plethora of endogenous modulators of angiogenesis have been identified and their roles in the molecular and cellular events that mediate and regulate…”
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Design, synthesis and biological evaluation of new peptide-based ureas and thioureas as potential antagonists of the thrombin receptor PAR1 by Ventosa-Andrés, Pilar, Valdivielso, Ángel M., Pappos, Ioannis, García-López, M. Teresa, Tsopanoglou, Nikos E., Herranz, Rosario

“…By applying a diversity oriented synthesis strategy for the search of new antagonists of the thrombin receptor PAR1, a series of peptide-based ureas and…”
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Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis by Zania, Panagiota, Kritikou, Sosanna, Flordellis, Christodoulos S, Maragoudakis, Michael E, Tsopanoglou, Nikos E

“…Many studies support the notion that protease-activated receptor (PAR)-1 plays a pivotal role in angiogenesis. However, direct evidence and understanding the…”
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Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis by Zania, Panagiota, Gourni, Despina, Aplin, Alfred C, Nicosia, Roberto F, Flordellis, Christodoulos S, Maragoudakis, Michael E, Tsopanoglou, Nikos E

“…The proteolytic activation by thrombin of the proteinase-activated receptor 1 unveils the tethered peptide ligand and cleaves a 41-amino acid peptide. In this…”
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Role of thrombin in angiogenesis and tumor progression by Tsopanoglou, Nikos E, Maragoudakis, Michael E

“…Clinical, laboratory, histopathological, and pharmacological evidence support the notion that the coagulation system, which is activated in most cancer…”
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Parstatin suppresses ocular neovascularization and inflammation by Huang, Hu, Vasilakis, Panagiotis, Zhong, Xiufeng, Shen, Ji-Kui, Geronatsiou, Katerina, Papadaki, Helen, Maragoudakis, Michael E, Gartaganis, Sotirios P, Vinores, Stanley A, Tsopanoglou, Nikos E

“…Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the PAR1 receptor. The authors recently showed that parstatin is a potent…”
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Thrombin promotes arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia model by Katsanos, Konstantinos, MD, Karnabatidis, Dimitrios, MD, PhD, Diamantopoulos, Athanasios, MD, Kagadis, George C., PhD, Ravazoula, Panagiota, MD, PhD, Nikiforidis, George C., PhD, Siablis, Dimitrios, MD, PhD, Tsopanoglou, Nikos E., PhD

“…Background Compared with angiogenesis, arteriogenesis is a distinct process based on the remodeling and maturation of pre-existing arterioles into large…”
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Highly functionalized 2-oxopiperazine-based peptidomimetics: An approach to PAR1 antagonists by Valdivielso, Ángel M., Ventosa-Andrés, Pilar, Tato, Francisco, Fernández-Ibañez, M. Ángeles, Pappos, Ioannis, Tsopanoglou, Nikos E., García-López, M. Teresa, Gutiérrez-Rodríguez, Marta, Herranz, Rosario

“…A series of pseudodipeptide-based chiral 1,3,4,5-tetrasubstituted-2-oxopiperazines has been designed and synthesized as potential PAR1 antagonists. These…”
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Thrombin mediates mitogenesis and survival of human endothelial cells through distinct mechanisms by Zania, Panagiota, Papaconstantinou, Matthew, Flordellis, Christodoulos S, Maragoudakis, Michael E, Tsopanoglou, Nikos E

“…Thrombin has been reported to play a pivotal role in the initiation of angiogenesis by indirectly regulating and organizing a network of angiogenic molecules…”
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Parstatin prevents renal injury following ischemia/reperfusion and radiocontrast administration by Diamantopoulos, Athanasios, Kyriazis, Iason, Geronatsiou, Katerina, Papadaki, Helen, Loudos, George, Kagadis, George C, Katsanos, Konstantinos, Liatsikos, Evangelos, Karnabatidis, Dimitrios, Siamblis, Dimitrios, Tsopanoglou, Nikos E

“…Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the protease-activated receptor 1. Parstatin was recently found to be…”
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Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury by Strande, Jennifer L., Widlansky, Michael E., Tsopanoglou, Nikos E., Su, Jidong, Wang, JingLi, Hsu, Anna, Routhu, Kasi V., Baker, John E.

“…Aims Thrombin activates protease-activated receptor 1 by proteolytic cleavage of the N-terminus. Although much research has focused on the activated receptor,…”
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Thrombin Functions through Its RGD Sequence in a Non-canonical Conformation by Papaconstantinou, Matthew E, Carrell, Christopher J, Pineda, Agustin O, Bobofchak, Kevin M, Mathews, F Scott, Flordellis, Christodoulos S, Maragoudakis, Michael E, Tsopanoglou, Nikos E, Di Cera, Enrico

“…Previous studies have suggested that thrombin interacts with integrins in endothelial cells through its RGD (Arg-187, Gly-188, Asp-189) sequence. All existing…”
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On the mechanism of thrombin-induced angiogenesis: inhibition of attachment of endothelial cells on basement membrane components by Tsopanoglou, Nikos E.

“…Human umbilical vein endothelial cells (HUVECs) placed on plastic plates coated with collagen type IV or laminin adhered within 60 min to an extent of about 32…”
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On the mechanism(s) of thrombin induced angiogenesis by Maragoudakis, M E, Tsopanoglou, N E

“…Promotion of tumour progression by thrombin is suggested by several clinical and laboratory observations. A plausible explanation for this effect of thrombin…”
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On the mechanism of thrombin-induced angiogenesis. Potentiation of vascular endothelial growth factor activity on endothelial cells by up-regulation of its receptors by Tsopanoglou, N E, Maragoudakis, M E

“…Many of the cellular actions of thrombin may contribute to the angiogenesis-promoting effect of thrombin reported previously. In this study, we investigated…”
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