Search Results - "Tsonaka, R."

Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden early arthritis clinic and ESPOIR cohorts by van Nies, J A B, Tsonaka, R, Gaujoux-Viala, C, Fautrel, B, van der Helm-van Mil, A H M

“…A prolonged symptom or disease duration at treatment initiation is associated with unfavourable outcomes in rheumatoid arthritis (RA). It is unknown whether…”
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Fixation and clinical outcome of uncemented peri-apatite-coated versus cemented total knee arthroplasty : five-year follow-up of a randomised controlled trial using radiostereometric analysis (RSA) by van Hamersveld, K T, Marang-van de Mheen, P J, Tsonaka, R, Valstar, E R, Toksvig-Larsen, S

“…The optimal method of tibial component fixation remains uncertain in total knee arthroplasty (TKA). Hydroxyapatite coatings have been applied to improve bone…”
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Sbk2, a Newly Discovered Atrium-Enriched Regulator of Sarcomere Integrity by van Gorp, P.R.R., Zhang, J., Liu, J., Tsonaka, R., Mei, H., Dekker, S.O., Bart, C.I., De Coster, T., Post, H., Heck, A.J.R., Schalij, M.J., Atsma, D.E., Pijnappels, D.A., de Vries, A.A.F.

“…Heart development relies on tight spatiotemporal control of cardiac gene expression. Genes involved in this intricate process have been identified using…”
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Evaluation of blood gene expression levels in facioscapulohumeral muscular dystrophy patients by Signorelli, M., Mason, A. G., Mul, K., Evangelista, T., Mei, H., Voermans, N., Tapscott, S. J., Tsonaka, R., van Engelen, B. G. M., van der Maarel, S. M., Spitali, P.

“…Facioscapulohumeral muscular dystrophy (FSHD) is caused by the expression of DUX4 in skeletal muscles. A number of therapeutic approaches are being developed…”
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A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis by de Rooy, D P C, Zhernakova, A, Tsonaka, R, Willemze, A, Kurreeman, B A S, Trynka, G, van Toorn, L, Toes, R E M, Huizinga, T W J, Houwing-Duistermaat, J J, Gregersen, P K, van der Helm-van Mil, A H M

“…The severity of joint destruction is highly variable between rheumatoid arthritis (RA) patients. The majority of its heritability is still unexplained. Several…”
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The logistic transform for bounded outcome scores by Lesaffre, Emmanuel, Rizopoulos, Dimitris, Tsonaka, Roula

“…The logistic transformation, originally suggested by Johnson (1949), is applied to analyze responses that are restricted to a finite interval (e.g. (0,1)),…”
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Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study by Knevel, R, Krabben, A, Brouwer, E, Posthumus, M D, Wilson, A G, Lindqvist, E, Saxne, T, de Rooy, D, Daha, N, van der Linden, M P M, Stoeken, G, van Toorn, L, Koeleman, B, Tsonaka, R, Zhernakoza, A, Houwing-Duistermaat, J J, Toes, R, Huizinga, T W J, van der Helm-van Mil, A

“…Interleukin (IL)-15 levels are increased in serum, synovium and bone marrow of patients with rheumatoid arthritis (RA). IL-15 influences both the innate and…”
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Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts by Knevel, R, de Rooy, D P, Gregersen, P K, Lindqvist, E, Wilson, A G, Gröndal, G, Zhernakova, A, van Nies, J A, Toes, R E, Tsonaka, R, Houwing-Duistermaat, J J, Steinsson, K, Huizinga, T W, Saxne, T, van der Helm-van Mil, A H

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Comparison of methodologies for analysing the progression of joint destruction in rheumatoid arthritis by Knevel, R, Tsonaka, R, le Cessie, S, van der Linden, MPM, Huizinga, TWJ, van der Heijde, DMFM, Houwing-Duistermaat, JJ, van der Helm-van Mil, AHM

“…Objectives: Progression of joint destruction is an important phenotypic feature in rheumatoid arthritis (RA). When factors have small effect sizes, both the…”
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Parameter constraints in generalized linear latent variable models by Tsonaka, R., Moustaki, I.

“…Parameter constraints in generalized linear latent variable models are discussed. Both linear equality and inequality constraints are considered. Maximum…”
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293P Evaluation of creatine/creatinine ratio and myostatin as monitoring biomarkers for DMD patients using real-world data by Degan, C., Vries, S., Ikelaar, N., Tsonaka, R., Niks, E., Spitali, P.

“…Duchenne muscular dystrophy (DMD) is characterized by delayed motor development and early loss of ambulation caused by a progressive reduction in muscle mass…”
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P3503Transcriptome changes in atrial myocytes during the transition from a proliferative into a contractile phenotype and vice versa by Liu, J, Tsonaka, R, Mei, H, Akerboom, B, Schalij, M, Pijnappels, D, De Vries, A

“…Abstract Background iAM-1 cells are conditionally immortalized neonatal rat atrial myocytes allowing toggling between proliferative and contractile phenotypes…”
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296P Development of monitoring biomarker signatures in Duchenne muscular dystrophy by De Vries, S., Degan, C., Tobin, R., Jimenéz-Requena, A., Ajeenah, A., Johansson, C., Van der Burgt, Y., Diaz-Manera, J., Guglieri, M., Szigyarto, C. Al-Khalili, Spitali, P., Hathout, Y., Tsonaka, R., Dang, U.

“…Duchenne muscular dystrophy (DMD) is an X-linked recessively inherited disease, resulting in the absence of dystrophin leading to muscle wasting. DMD patients…”
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284P Suspension bead array profiling of 1018 serum proteins in search for disease progression biomarkers for Duchenne muscular dystrophy by Carrasco, A. Jiménez-Requena, Ajeenah, A., Johansson, C., Naveed, A., Tobin, R., Degan, C., de Vries, S., van der Burgt, Y., Diaz-Manera, J., Guglieri, M., Dang, U., Tsonaka, R., Spitali, P., Hathout, Y., Szigyarto, C. Al-Khalili

“…Neuromuscular disorders, like Duchenne muscular dystrophy (DMD), are rare, incurable and life-threatening diseases characterized by progressive muscle…”
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Transcriptome analysis of conditionally immortalized atrial myocytes: identification of a novel atrium-enriched protein involved in sarcomere assembly and maintenance by Van Gorp, P R R, Zhang, J, Liu, J, Tsonaka, R, Mei, H, Dekker, S O, Bart, C I, Schalij, M J, De Coster, T, Atsma, D A, Pijnappels, D A, De Vries, A A F

“…Abstract Background Heart development relies on the tight spatiotemporal control of cardiac gene expression. Genes involved in these processes have been…”
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Penalized regression calibration: A method for the prediction of survival outcomes using complex longitudinal and high‐dimensional data by Signorelli, Mirko, Spitali, Pietro, Szigyarto, Cristina Al‐Khalili, Tsonaka, Roula

“…Longitudinal and high‐dimensional measurements have become increasingly common in biomedical research. However, methods to predict survival outcomes using…”
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Quality of life after curative resection for rectal cancer in patients treated with adjuvant chemotherapy compared with observation: results of the randomized phase III SCRIPT trial by van der Valk, M., Hilling, D., Meershoek-Klein Kranenbarg, E., Peeters, K., Kapiteijn, E., Tsonaka, R., Van de Velde, C., Marang- van de Mheen, P.

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D13 - Metabolomics analysis in serum of muscular dystrophy patients by Spitali, P., Hettne, K., Tsonaka, R., Sabir, E., Seyer, A., Hemerik, J.B.A., Goeman, J.J., Picillo, E., Ergoli, M., Politano, L., Aartsma-Rus, A.

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Metabolomics analysis in serum of muscular dystrophy patients by Spitali, P., Hettne, K., Tsonaka, R., Sabir, E., Seyer, A., Hemerik, J.B.A., Goeman, J.J., Picillo, E., Ergoli, M., Politano, L., Aartsma-Rus, A.

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P.242 - Longitudinal proteomic analysis of sera allows to non-invasively monitor disease progression in Duchenne muscular dystrophy by Spitali, P., Tsonaka, R., Hettne, K., Koeks, Z., Roos, A., Straub, V., Piscos Domingos, J., Muntoni, F., Al-Khalili-Szigyarto, C., Lochmüller, H., Niks, E., Aartsma-Rus, A.

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