Search Results - "Tsogoeva, Svetlana B"
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Structural hybridization as a facile approach to new drug candidates
Published in Bioorganic & medicinal chemistry letters (01-12-2020)“…[Display omitted] Structural hybridization of preclinically and clinically validated pharmacologically active molecules has emerged as a promising tool to…”
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2
Catalytic multi-step domino and one-pot reactions
Published in Beilstein journal of organic chemistry (08-02-2024)Get full text
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3
Chiral BINOL-derived phosphoric acids: privileged Brønsted acid organocatalysts for C-C bond formation reactions
Published in Organic & biomolecular chemistry (07-12-2010)“…BINOL-derived phosphoric acids have emerged during the last five years as powerful chiral Brønsted acid catalysts in many enantioselective processes. The most…”
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4
Recent progress in the development of synthetic hybrids of natural or unnatural bioactive compounds for medicinal chemistry
Published in Mini reviews in medicinal chemistry (01-08-2010)“…The present mini-review highlights the recent developments on different classes of synthetic hybrids of natural and/or unnatural bioactive compounds, the…”
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5
Hückel and Möbius Aromaticity in Charged Sigma Complexes
Published in Chemistry : a European journal (04-06-2019)“…In sigma complexes, intermediates in nucleophilic and electrophilic aromatic substitution and other reactions, delocalization in the aromatic ring is formally…”
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6
Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models
Published in Chemistry : a European journal (19-01-2022)“…The presently ongoing pandemic of human SARS‐CoV‐2 infections (COVID‐19) presents an enormous challenge in surveillance, vaccine and antiviral drug…”
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7
Developments in Chiral Binaphthyl-Derived Brønsted/Lewis Acids and Hydrogen-Bond-Donor Organocatalysis
Published in European Journal of Organic Chemistry (01-04-2011)“…In recent years, binaphthyl compounds have found frequent applications in the design of various asymmetric organocatalysts, because binaphthyl structures are…”
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Demonstration of "Möbius" Aromaticity in Planar Metallacycles
Published in Chemistry : a European journal (12-07-2010)“…Möbius aromaticity, predicted by Edgar Heilbronner in 1964, is a stabilizing effect exhibited by 4 n electron fully conjugated cyclic molecules (or transition…”
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Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria
Published in Angewandte Chemie International Edition (09-09-2019)“…A substantial challenge worldwide is emergent drug resistance in malaria parasites against approved drugs, such as chloroquine (CQ). To address these unsolved…”
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10
Generation of Highly Enantioenriched Crystalline Products in Reversible Asymmetric Reactions with Racemic or Achiral Catalysts
Published in Angewandte Chemie (International ed.) (01-01-2009)“…Backwards is better: By combining forward and backward reaction steps of a reversible chemical process (see scheme) with the physical processes of…”
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11
Photoracemization‐Based Viedma Ripening of a BINOL Derivative
Published in Chemistry : a European journal (16-01-2020)“…Viedma ripening is a deracemization process that has been used to deracemize a range of chiral molecules. The method has two major requirements: the compound…”
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Chemical hybridization of sulfasalazine and dihydroartemisinin promotes brain tumor cell death
Published in Scientific reports (21-10-2021)“…Gliomas are primary brain tumors with still poor prognosis for the patients despite a combination of cytoreduction via surgery followed by a…”
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13
(Iso)Quinoline–Artemisinin Hybrids Prepared through Click Chemistry: Highly Potent Agents against Viruses
Published in Chemistry : a European journal (16-09-2020)“…Viral infections cause life‐threatening diseases in millions of people worldwide every year and there is an urgent need for new, effective antiviral drugs…”
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14
Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
Published in Nature communications (02-05-2017)“…Most of the known approved drugs comprise functionalized heterocyclic compounds as subunits. Among them, non-fluorescent quinazolines with four different…”
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Enantioselective Cycloaddition Reactions Catalyzed by BINOL-Derived Phosphoric Acids and N-Triflyl Phosphoramides: Recent Advances
Published in Molecules (03-09-2015)“…Over the last several years there has been a huge increase in the development and applications of new efficient organocatalysts for enantioselective pericyclic…”
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Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus Activity
Published in International journal of molecular sciences (27-11-2021)“…Human cytomegalovirus (HCMV) is a major pathogenic herpesvirus that is prevalent worldwide and it is associated with a variety of clinical symptoms. Current…”
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Combinatorial Drug Treatments Reveal Promising Anticytomegaloviral Profiles for Clinically Relevant Pharmaceutical Kinase Inhibitors (PKIs)
Published in International journal of molecular sciences (08-01-2021)“…Human cytomegalovirus (HCMV) is a human pathogenic herpesvirus associated with a variety of clinical symptoms. Current antiviral therapy is not always…”
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Chiral Thiourea-Based Bifunctional Organocatalysts in the Asymmetric Nitro-Michael Addition: A Joint Experimental-Theoretical Study
Published in Advanced synthesis & catalysis (01-05-2006)“…A highly enantioselective (84–92% ee) organocatalytic Michael addition of acetone to aromatic nitroolefins has been described. The transition state geometries…”
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Treatment of Multidrug-Resistant Leukemia Cells by Novel Artemisinin-, Egonol-, and Thymoquinone-Derived Hybrid Compounds
Published in Molecules (Basel, Switzerland) (06-04-2018)“…Two major obstacles for successful cancer treatment are the toxicity of cytostatics and the development of drug resistance in cancer cells during chemotherapy…”
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Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide‐Based Hybrid Compounds against SARS‐CoV‐2 and Cancer
Published in ChemMedChem (04-05-2022)“…The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) cause life‐threatening diseases in millions of people worldwide, in particular,…”
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