Search Results - "Tsintsadze, Timur"

Early Gamma Oscillations Synchronize Developing Thalamus and Cortex by Minlebaev, Marat, Colonnese, Matthew, Tsintsadze, Timur, Sirota, Anton, Khazipov, Roustem

“…During development, formation of topographic maps in sensory cortex requires precise temporal binding in thalamocortical networks. However, the physiological…”
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Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring by Tyzio, Roman, Nardou, Romain, Ferrari, Diana C., Tsintsadze, Timur, Shahrokhi, Amene, Eftekhari, Sanaz, Khalilov, Ilgam, Tsintsadze, Vera, Brouchoud, Corinne, Chazal, Genevieve, Lemonnier, Eric, Lozovaya, Natalia, Burnashev, Nail, Ben-Ari, Yehezkel

“…We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and…”
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Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels by Martiszus, Briana J, Tsintsadze, Timur, Chang, Wenhan, Smith, Stephen M

“…Increasing extracellular [Ca2+] ([Ca2+]o) strongly decreases intrinsic excitability in neurons but the mechanism is unclear. By one hypothesis, [Ca2+]o screens…”
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Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons by Steiger, Luke J., Tsintsadze, Timur, Mattheisen, Glynis B., Smith, Stephen M.

“…Endogenous cannabinoid signaling is vital for important brain functions, and the same pathways can be modified pharmacologically to treat pain, epilepsy, and…”
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Strong G-Protein-Mediated Inhibition of Sodium Channels by Mattheisen, Glynis B., Tsintsadze, Timur, Smith, Stephen M.

“…Voltage-gated sodium channels (VGSCs) are strategically positioned to mediate neuronal plasticity because of their influence on action potential waveform. VGSC…”
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Direct whole-cell patch-clamp recordings from small boutons in rodent primary neocortical neuron cultures by Ritzau-Jost, Andreas, Nerlich, Jana, Kaas, Thomas, Krueger, Martin, Tsintsadze, Timur, Eilers, Jens, Barbour, Boris, Smith, Stephen M., Hallermann, Stefan

“…Direct electrical recordings from conventional boutons in the mammalian central nervous system have proven challenging due to their small size. Here, we…”
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N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse by Costa, Blaise Mathias, Feng, Bihua, Tsintsadze, Timur S, Morley, Richard M, Irvine, Mark W, Tsintsadze, Vera, Lozovaya, Natasha A, Jane, David E, Monaghan, Daniel T

“…N-Methyl-d-aspartate (NMDA) receptor antagonists that are highly selective for specific NMDA receptor 2 (NR2) subunits have several potential therapeutic…”
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Large, Stable Spikes Exhibit Differential Broadening in Excitatory and Inhibitory Neocortical Boutons by Ritzau-Jost, Andreas, Tsintsadze, Timur, Krueger, Martin, Ader, Jonas, Bechmann, Ingo, Eilers, Jens, Barbour, Boris, Smith, Stephen M., Hallermann, Stefan

“…Presynaptic action potential spikes control neurotransmitter release and thus interneuronal communication. However, the properties and the dynamics of…”
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Acid sensing ionic channels: Modulation by redox reagents by Andrey, Fedorenko, Tsintsadze, Timur, Volkova, Tatyana, Lozovaya, Natalia, Krishtal, Oleg

“…Acid-sensing ion channels (ASICs) are widely expressed in mammalian sensory neurons and supposedly play a role in nociception and acid sensing. In the course…”
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Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ‘superslow’ afterburst EPSC in rat hippocampus by Lozovaya, Natasha A., Grebenyuk, Sergei E., Tsintsadze, Timur Sh, Feng, Bihua, Monaghan, Daniel T., Krishtal, Oleg A.

“…In conditions of facilitated synaptic release, CA3/CA1 synapses generate anomalously slow NMDA receptor‐mediated EPSCs (EPSCNMDA). Such a time course has been…”
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Diadenosine polyphosphate analog controls postsynaptic excitation in CA3-CA1 synapses via a nitric oxide-dependent mechanism by Melnik, Sergei, Wright, Michael, Tanner, Julian A, Tsintsadze, Timur, Tsintsadze, Vera, Miller, Andrew D, Lozovaya, Natalia

“…Previously, we have described the modulatory effect of diadenosine polyphosphates Ap4A and Ap5A on synaptic transmission in the rat hippocampal slices mediated…”
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Post-synaptic N-methyl- d-aspartate signalling in hippocampal neurons of rat: spillover increases the impact of each spike in a short burst discharge by Grebenyuk, Sergei E., Lozovaya, Natasha A., Tsintsadze, Timur S., Krishtal, Oleg A.

“…High-frequency burst discharges in hippocampus typically consist of less than ten spikes fired at frequencies too high to be followed by a post-synaptic…”
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GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction by Lesca, Gaetan, Rudolf, Gabrielle, Bruneau, Nadine, Lozovaya, Natalia, Labalme, Audrey, Boutry-Kryza, Nadia, Salmi, Manal, Tsintsadze, Timur, Addis, Laura, Motte, Jacques, Wright, Sukhvir, Tsintsadze, Vera, Michel, Anne, Doummar, Diane, Lascelles, Karine, Strug, Lisa, Waters, Patrick, de Bellescize, Julitta, Vrielynck, Pascal, de Saint Martin, Anne, Ville, Dorothee, Ryvlin, Philippe, Arzimanoglou, Alexis, Hirsch, Edouard, Vincent, Angela, Pal, Deb, Burnashev, Nail, Sanlaville, Damien, Szepetowski, Pierre

“…Pierre Szepetowski and colleagues report the identification of mutations in GRIN2A in individuals with acquired epileptic aphasia and related childhood focal…”
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Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons by Fisunov, A, Lozovaya, N, Tsintsadze, T, Chatterjee, S, Nöldner, M, Krishtal, O

“…Whole-cell, patch-clamp recordings from acutely isolated cerebellar Purkinje neurons demonstrate a two-stage modulation of P-type high-voltage-activated (HVA)…”
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Distinct Actions of Voltage-Activated Ca2+ Channel Block on Spontaneous Release at Excitatory and Inhibitory Central Synapses by Tsintsadze, Timur, Williams, Courtney L, Weingarten, Dennis J, von Gersdorff, Henrique, Smith, Stephen M

“…At chemical synapses, voltage-activated calcium channels (VACCs) mediate Ca2+ influx to trigger action potential-evoked neurotransmitter release. However, the…”
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Distinct Actions of Voltage-Activated Ca super(2+) Channel Block on Spontaneous Release at Excitatory and Inhibitory Central Synapses by Tsintsadze, Timur, Williams, Courtney L, Weingarten, Dennis J, von Gersdorff, Henrique, Smith, Stephen M

“…At chemical synapses, voltage-activated calcium channels (VACCs) mediate Ca super(2+) influx to trigger action potential-evoked neurotransmitter release…”
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Control of Inhibition by the Direct Action of Cannabinoids on GABA A Receptors by Golovko, Tatiana, Min, Rogier, Lozovaya, Natalia, Falconer, Caroline, Yatsenko, Natalia, Tsintsadze, Timur, Tsintsadze, Vera, Ledent, Catherine, Harvey, Robert J., Belelli, Delia, Lambert, Jeremy J., Rozov, Andrei, Burnashev, Nail

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Diadenosine-Polyphosphate Analogue AppCH2ppA Suppresses Seizures by Enhancing Adenosine Signaling in the Cortex by Pons-Bennaceur, Alexandre, Tsintsadze, Vera, Bui, Thi-Thien, Tsintsadze, Timur, Minlebaev, Marat, Milh, Mathieu, Scavarda, Didier, Giniatullin, Rashid, Giniatullina, Raisa, Shityakov, Sergey, Wright, Michael, Miller, Andrew D, Lozovaya, Natalia, Burnashev, Nail

“…Epilepsy is a multifactorial disorder associated with neuronal hyperexcitability that affects more than 1% of the human population. It has long been known that…”
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Control of Inhibition by the Direct Action of Cannabinoids on GABAA Receptors by Golovko, Tatiana, Min, Rogier, Lozovaya, Natalia, Falconer, Caroline, Yatsenko, Natalia, Tsintsadze, Timur, Tsintsadze, Vera, Ledent, Catherine, Harvey, Robert J, Belelli, Delia, Lambert, Jeremy J, Rozov, Andrei, Burnashev, Nail

“…Cannabinoids are known to regulate inhibitory synaptic transmission via activation of presynaptic G protein-coupled cannabinoid CB1 receptors (CB1Rs)…”
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Diadenosine-Polyphosphate Analogue AppCH2ppA Suppresses Seizures by Enhancing Adenosine Signaling in the Cortex by Pons-Bennaceur, Alexandre, Tsintsadze, Vera, Bui, Thi-Thien, Tsintsadze, Timur, Minlebaev, Marat, Milh, Mathieu, Scavarda, Didier, Giniatullin, Rashid, Giniatullin, Raisa, Shityakov, Sergey, Bui, Michael, Bui, Andrew, Lozovaya, Natalia, Burnashev, Nail

“…Epilepsy is a multifactorial disorder associated with neuronal hyperexcitability that affects more than 1% of the human population. It has long been known that…”
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