Search Results - "Tsintsadze, T"
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Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model
Published in Nature communications (01-08-2014)“…Tuberous sclerosis complex (TSC), caused by dominant mutations in either TSC1 or TSC2 tumour suppressor genes is characterized by the presence of brain…”
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Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model
Published in Nature communications (01-08-2014)Get full text
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Etiologic agents of central nervous system infections in Georgia
Published in Journal of the neurological sciences (15-10-2013)Get full text
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Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum
Published in Pharmacopsychiatry (01-07-2001)“…Despite almost forty years of widespread use of antidepressant drugs, their mode of action is still unknown. Hyperforin, a phloroglucinol derivative, is a…”
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Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring
Published in Science (American Association for the Advancement of Science) (07-02-2014)“…We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and…”
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Natural-water availability in Georgia
Published in Water resources (01-02-2007)“…Water availability in Georgia is estimated for two 40-year periods (1921-1960 and 1961-2000). A map is presented to show excessive and deficient water…”
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Treatment and rehabilitation of hydatidiform mole
Published in Annals of oncology (01-11-2017)Get full text
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Latent N-methyl-D-aspartate receptors in the recurrent excitatory pathway between hippocampal CA1 pyramidal neurons: Ca(2+)-dependent activation by blocking A1 adenosine receptors
Published in Proceedings of the National Academy of Sciences - PNAS (19-12-1995)“…When performed at increased external [Ca2+]/[Mg2+] ratio (2.5 mM/0.5 mM), temporary block of A1 adenosine receptors in hippocampus [by…”
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New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons
Published in Neuropharmacology (2001)“…A new substance (R,S)-(3,4-dihydro-6,7-dimethoxyisoquinoline-1-yl)-2-cyclohexyl-N-(3,3-diphenylpropyl)-acetamide hydrochloride (BIIA388Cl), which demonstrates…”
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Glycine Receptors in CNS Neurons as a Target for Nonretrograde Action of Cannabinoids
Published in The Journal of neuroscience (17-08-2005)“…At many central synapses, endocannabinoids released by postsynaptic cells act retrogradely on presynaptic G-protein-coupled cannabinoid receptors to inhibit…”
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Effects of Long-Term Hypoxia/Hypoglycemia on Synaptic Transmission between the CA3 and CA1 Zones in Rat Hippocampal Slices
Published in Neurophysiology (New York) (01-11-2001)“…On rat hippocampal slices using a standard patch-clamp technique in the whole-cell configuration, we studied the effects of long-term (40 to 60 min)…”
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Acid sensing ionic channels: Modulation by redox reagents
Published in Biochimica et biophysica acta (15-08-2005)“…Acid-sensing ion channels (ASICs) are widely expressed in mammalian sensory neurons and supposedly play a role in nociception and acid sensing. In the course…”
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Glutamate Postsynaptic Receptors under the Cap: Strictly Limited Access to Receptors in the Postsynaptic Density by Non-Synaptically Released Glutamate
Published in Neurophysiology (New York) (01-03-2002)“…Astroglia is capable of releasing glutamate (Glu) in concentrations sufficient to activate ionotropic Glu receptors. Provided the released Glu reaches the…”
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Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density
Published in Brain research (18-06-2004)“…Numerous data indicate that nonsynaptic release of glutamate occurs both in normal and pathophysiological conditions. When reaching receptors in the…”
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The synthetic cannabinoid analog WIN 55,212-2 potentiates the amplitudes of glycine-activated currents
Published in Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) (2007)“…Most of the pharmacological actions of cannabinoids are mediated by CB1 receptors. There is also evidence that these compounds can produce effects that are not…”
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Employment of the laser apparatus SL-30 in complex treatment of chronic recurrent herpetic stomatitis
Published in Georgian medical news (01-09-2005)“…The purpose of the study was the estimation of complex treatment effectiveness of chronic recurrent herpetic stomatitis using portable laser device "Beurer"…”
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Autoregulation of cerebral blood flow in condition of experimental hepatic encephalopathy
Published in Georgian medical news (01-04-2007)“…The linear interrelation between Systemic Arterial Blood Pressure and local Cerebral Blood Flow has been shown in experiments on rats with induced experimental…”
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Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons
Published in Pflügers Archiv (01-07-2000)“…Whole-cell, patch-clamp recordings from acutely isolated cerebellar Purkinje neurons demonstrate a two-stage modulation of P-type high-voltage-activated (HVA)…”
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Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ‘superslow’ afterburst EPSC in rat hippocampus
Published in The Journal of physiology (15-07-2004)“…In conditions of facilitated synaptic release, CA3/CA1 synapses generate anomalously slow NMDA receptor‐mediated EPSCs (EPSCNMDA). Such a time course has been…”
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