Search Results - "Tsinman, Oksana"

Ranking Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane by Tsinman, Konstantin, Tsinman, Oksana, Lingamaneni, Ram, Zhu, Saijie, Riebesehl, Bernd, Grandeury, Arnaud, Juhnke, Michael, Van Eerdenbrugh, Bernard

“…Purpose The goal of the study was to evaluate a miniaturized dissolution-permeation apparatus (μFLUX™ apparatus) for its ability to benchmark several…”
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Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods by Borbás, Enikő, Kádár, Szabina, Tsinman, Konstantin, Tsinman, Oksana, Csicsák, Dóra, Takács-Novák, Krisztina, Völgyi, Gergely, Sinkó, Bálint, Pataki, Hajnalka

“…In this work, two different approaches have been developed to predict the food effect and the bioequivalence of marketed itraconazole (ITRA) formulations…”
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P-glycoprotein deficient mouse in situ blood–brain barrier permeability and its prediction using an in combo PAMPA model by Dagenais, Claude, Avdeef, Alex, Tsinman, Oksana, Dudley, Adam, Beliveau, Richard

“…The purpose of the study was to assess the permeability of mouse blood–brain barrier (BBB) to a diverse set of compounds in the absence of P-glycoprotein (Pgp)…”
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The Permeation of Amphoteric Drugs through Artificial Membranes − An in Combo Absorption Model Based on Paracellular and Transmembrane Permeability by Tam, Kin Y, Avdeef, Alex, Tsinman, Oksana, Sun, Na

“…The permeability characteristics of 33 amphoteric drugs (about 64% zwitterions at physiological pH) were studied using the parallel artificial membrane…”
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Miniaturized Rotating Disk Intrinsic Dissolution Rate Measurement: Effects of Buffer Capacity in Comparisons to Traditional Wood’s Apparatus by Avdeef, Alex, Tsinman, Oksana

“…Purpose The objective was to investigate the feasibility of using a miniaturized disk intrinsic dissolution rate (IDR) apparatus to determine the…”
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Food effect risk assessment in preformulation stage using material sparing µFLUX methodology by Jankovsky, Corinne, Tsinman, Oksana, Thakral, Naveen

“…The intake of food and meal type can strongly impact the bioavailability of orally administered drugs and can consequently impact drug efficacy and safety…”
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Acid-Base Cosolvent Method for Determining Aqueous Permeability of Amiodarone, Itraconazole, Tamoxifen, Terfenadine and Other Very Insoluble Molecules by Ruell, Jeffrey Alan, Tsinman, Oksana, Avdeef, Alex

“…A high-throughput, UV-detection PAMPA (parallel artificial membrane permeability assay) cosolvent procedure is described, based on the use of 20% v/v…”
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Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products by Li, Jane, Tsinman, Konstantin, Tsinman, Oksana, Wigman, Larry

“…ABSTRACT This study described a pH-gradient dissolution method combined with flux measurements as an in vitro tool for assessing the risk of bioavailability…”
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Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion--Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model by Tsinman, Oksana, Tsinman, Konstantin, Sun, Na, Avdeef, Alex

“…Purpose To mimic the physicochemical selectivity of the blood-brain barrier (BBB) and to predict its passive permeability using a PAMPA model based on porcine…”
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The effect of formulation additives on in vitro dissolution-absorption profile and in vivo bioavailability of telmisartan from brand and generic formulations by Borbás, Enikő, Nagy, Zsombor K., Nagy, Brigitta, Balogh, Attila, Farkas, Balázs, Tsinman, Oksana, Tsinman, Konstantin, Sinkó, Bálint

“…In this study, brand and four generic formulations of telmisartan, an antihypertensive drug, were used in in vitro simultaneous dissolution-absorption,…”
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Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs by Tsinman, Konstantin, Avdeef, Alex, Tsinman, Oksana, Voloboy, Dmytro

“…Purpose The objective was to investigate the applicability and limitations of a novel approach for measuring intrinsic dissolution rates (IDR) of very small…”
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Skin–PAMPA: A new method for fast prediction of skin penetration by Sinkó, Bálint, Garrigues, Teresa M., Balogh, György T., Nagy, Zsombor K., Tsinman, Oksana, Avdeef, Alex, Takács-Novák, Krisztina

“…The goal of this study was to develop a quick, reliable, and cost-effective permeability model for predicting transdermal penetration of compounds. The…”
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Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media by Fagerberg, Jonas H, Tsinman, Oksana, Sun, Na, Tsinman, Konstantin, Avdeef, Alex, Bergström, Christel A. S

“…A series of poorly soluble BCS class II compounds with “grease ball” characteristics were assessed for solubility and dissolution rate in biorelevant…”
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Spectrophotometric pKa determination of ionizable pharmaceuticals: Resolution of molecules with weak pH-dependent spectral shift by Dohoda, Deren, Tsinman, Konstantin, Tsinman, Oksana, Wang, Haotian, Tam, Kin Y.

“…•A UV method for measuring pKa of drugs with weak spectral shift is developed.•The pKa values determined are in good agreement with literature data…”
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Investigation and Mathematical Description of the Real Driving Force of Passive Transport of Drug Molecules from Supersaturated Solutions by Borbás, Enikő, Sinkó, Bálint, Tsinman, Oksana, Tsinman, Konstantin, Kiserdei, Éva, Démuth, Balázs, Balogh, Attila, Bodák, Brigitta, Domokos, András, Dargó, Gergő, Balogh, György T, Nagy, Zsombor K

“…The aim of this study was to investigate the impact of formulation excipients and solubilizing additives on dissolution, supersaturation, and membrane…”
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PAMPA : A drug absorption in vitro model 13. chemical selectivity due to membrane hydrogen bonding: In combo comparisons of HDM-, DOPC-, and DS-PAMPA models by AVDEEF, Alex, TSINMAN, Oksana

“…This study compares the intrinsic permeability coefficients of 40 drug molecules, obtained by three popular variants of the PAMPA assay, based on: (a)…”
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Flux-Based Formulation Development—A Proof of Concept Study by Kádár, Szabina, Tőzsér, Petra, Nagy, Brigitta, Farkas, Attila, Nagy, Zsombor K., Tsinman, Oksana, Tsinman, Konstantin, Csicsák, Dóra, Völgyi, Gergely, Takács-Novák, Krisztina, Borbás, Enikő, Sinkó, Bálint

“…The work aimed to develop the Absorption Driven Drug Formulation (ADDF) concept, which is a new approach in formulation development to ensure that the drug…”
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Solubility-excipient classification gradient maps by AVDEEF, Alex, BENDELS, Stefanie, TSINMAN, Oksana, TSINMAN, Konstantin, KANSY, Manfred

“…This study assessed the effect of excipients (sodium taurocholate, 2-hydroxypropyl-f-cyclodextrin, potassium chloride, propylene glycol,…”
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Effect of Formulation Additives on Drug Transport through Size-Exclusion Membranes by Borbás, Enikő, Tőzsér, Petra, Tsinman, Konstantin, Tsinman, Oksana, Takács-Novák, Krisztina, Völgyi, Gergely, Sinkó, Bálint, Nagy, Zsombor K

“…The aim of this research was to investigate the driving force of membrane transport through size-exclusion membranes and to provide a concentration-based…”
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PAMPA—a drug absorption in vitro model: 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates by Avdeef, Alex, Nielsen, Per E, Tsinman, Oksana

“…Many plate-based in vitro assays of membrane permeability (e.g., Caco-2, MDCK, PAMPA) of sparingly soluble candidate molecules report permeability of water,…”
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