Search Results - "Tsimbouri, Penelope. M."

Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants by Damiati, Laila, Eales, Marcus G, Nobbs, Angela H, Su, Bo, Tsimbouri, Penelope M, Salmeron-Sanchez, Manuel, Dalby, Matthew J

“…Titanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental implants. Despite the majority of Ti implants having long-term…”
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Antibacterial surface modification of titanium implants in orthopaedics by Orapiriyakul, Wich, Young, Peter S, Damiati, Laila, Tsimbouri, Penelope M

“…The use of biomaterials in orthopaedics for joint replacement, fracture healing and bone regeneration is a rapidly expanding field. Infection of these…”
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Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells by Donnelly, Hannah, Ross, Ewan, Xiao, Yinbo, Hermantara, Rio, Taqi, Aqeel F., Doherty-Boyd, W. Sebastian, Cassels, Jennifer, Tsimbouri, Penelope. M., Dunn, Karen M., Hay, Jodie, Cheng, Annie, Meek, R. M. Dominic, Jain, Nikhil, West, Christopher, Wheadon, Helen, Michie, Alison M., Peault, Bruno, West, Adam G., Salmeron-Sanchez, Manuel, Dalby, Matthew J.

“…Long-term reconstituting haematopoietic stem cells (LT-HSCs) are used to treat blood disorders via stem cell transplantation. The very low abundance of LT-HSCs…”
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Adult Stem Cell Responses to Nanostimuli by Tsimbouri, Penelope M

“…Adult or mesenchymal stem cells (MSCs) have been found in different tissues in the body, residing in stem cell microenvironments called "stem cell niches"…”
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Analysis of Osteoclastogenesis/Osteoblastogenesis on Nanotopographical Titania Surfaces by Silverwood, Robert K., Fairhurst, Paul G., Sjöström, Terje, Welsh, Findlay, Sun, Yuxin, Li, Gang, Yu, Bin, Young, Peter S., Su, Bo, Meek, Robert M. D., Dalby, Matthew J., Tsimbouri, Penelope M.

“…A focus of orthopedic research is to improve osteointegration and outcomes of joint replacement. Material surface topography has been shown to alter cell…”
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Osteoblast response to disordered nanotopography by Allan, Christopher, Ker, Andrew, Smith, Carol-Anne, Tsimbouri, Penelope M, Borsoi, Juliana, O’Neill, Stewart, Gadegaard, Nikolaj, Dalby, Matthew J, Dominic Meek, RM

“…The ability to influence stem cell differentiation is highly desirable as it would help us improve clinical outcomes for patients in various aspects. Many…”
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Lymphoid hyperplasia and lymphoma in transgenic mice expressing the small non-coding RNA, EBER1 of Epstein-Barr virus by Repellin, Claire E, Tsimbouri, Penelope M, Philbey, Adrian W, Wilson, Joanna B

“…Non-coding RNAs have critical functions in diverse biological processes, particularly in gene regulation. Viruses, like their host cells, employ such…”
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Biomimetic oyster shell–replicated topography alters the behaviour of human skeletal stem cells by Waddell, Shona J, de Andrés, María C, Tsimbouri, Penelope M, Alakpa, Enateri V, Cusack, Maggie, Dalby, Matthew J, Oreffo, Richard OC

“…The regenerative potential of skeletal stem cells provides an attractive prospect to generate bone tissue needed for musculoskeletal reparation. A central…”
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Lymphocyte deficiency limits Epstein-Barr virus latent membrane protein 1 induced chronic inflammation and carcinogenic pathology in vivo by Hannigan, Adele, Qureshi, Asif M, Nixon, Colin, Tsimbouri, Penelope M, Jones, Sarah, Philbey, Adrian W, Wilson, Joanna B

“…The importance of the malignant cell environment to its growth and survival is becoming increasingly apparent, with dynamic cross talk between the neoplastic…”
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Titanium Surface Synergy: Strontium Incorporation and Controlled Disorder Nanotopography Optimize Osteoinduction by Young, Peter S., Greer, Andrew I. M., Smith, Carol-Anne, Silverwood, Robert K., Tsimbouri, Penelope M., Meek, Dominic, Goodyear, Carl, Gadegaard, Nikolaj, Dalby, Matthew J.

“…Osteoporotic fractures and arthritis represent a major socioeconomic health burden. Fragility fracture fixation and joint replacement are often undertaken…”
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Hybrid Micro-/Nanoprotein Platform Provides Endocrine-like and Extracellular Matrix-like Cell Delivery of Growth Factors by López-Laguna, Hèctor, Tsimbouri, Penelope M., Jayawarna, Vineetha, Rigou, Ioanna, Serna, Naroa, Voltà-Durán, Eric, Unzueta, Ugutz, Salmeron-Sanchez, Manuel, Vázquez, Esther, Dalby, Matthew J., Villaverde, Antonio

“…Protein materials are versatile tools in diverse biomedical fields. Among them, artificial secretory granules (SGs), mimicking those from the endocrine system,…”
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Nanotopography Influences Host–Pathogen Quorum Sensing and Facilitates Selection of Bioactive Metabolites in Mesenchymal Stromal Cells and Pseudomonas aeruginosa Co-Cultures by Cuahtecontzi Delint, Rosalia, Ishak, Mohd I., Tsimbouri, Penelope M., Jayawarna, Vineetha, Burgess, Karl V. E., Ramage, Gordon, Nobbs, Angela H., Damiati, Laila, Salmeron-Sanchez, Manuel, Su, Bo, Dalby, Matthew J.

“…Orthopedic implant-related bacterial infections and resultant antibiotic-resistant biofilms hinder implant–tissue integration and failure. Biofilm quorum…”
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Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis by Campsie, Paul, Childs, Peter G., Robertson, Shaun N., Cameron, Kenny, Hough, James, Salmeron-Sanchez, Manuel, Tsimbouri, Penelope M., Vichare, Parag, Dalby, Matthew J., Reid, Stuart

“…In regenerative medicine, techniques which control stem cell lineage commitment are a rapidly expanding field of interest. Recently, nanoscale mechanical…”
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A genomics approach in determining nanotopographical effects on MSC phenotype by Tsimbouri, Penelope M, Murawski, Kate, Hamilton, Graham, Herzyk, Pawel, Oreffo, Richard O.C, Gadegaard, Nikolaj, Dalby, Matthew J

“…Abstract Topography and its effects on cell adhesion, morphology, growth and differentiation are well documented. Thus, current advances with the use of…”
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Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands by Fraioli, Roberta, Tsimbouri, Penelope M., Fisher, Leanne E., Nobbs, Angela H., Su, Bo, Neubauer, Stefanie, Rechenmacher, Florian, Kessler, Horst, Ginebra, Maria-Pau, Dalby, Matthew J., Manero, José M., Mas-Moruno, Carlos

“…Engineering the interface between biomaterials and tissues is important to increase implant lifetime and avoid failures and revision surgeries. Permanent…”
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Microtopographical cues promote peripheral nerve regeneration via transient mTORC2 activation by Thomson, Suzanne E., Charalambous, Chloe, Smith, Carol-Anne, Tsimbouri, Penelope M., Déjardin, Theophile, Kingham, Paul J., Hart, Andrew M., Riehle, Mathis O.

“…[Display omitted] Despite microsurgical repair, recovery of function following peripheral nerve injury is slow and often incomplete. Outcomes could be improved…”
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Nanotextured titanium inhibits bacterial activity and supports cell growth on 2D and 3D substrate: A co-culture study by Ishak, Mohd I, Delint, Rosalia Cuahtecontzi, Liu, Xiayi, Xu, Wei, Tsimbouri, Penelope M, Nobbs, Angela H, Dalby, Matthew J, Su, Bo

“…Medical implant-associated infections pose a significant challenge to modern medicine, with aseptic loosening and bacterial infiltration being the primary…”
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Material-driven fibronectin assembly for high-efficiency presentation of growth factors by Llopis-Hernández, Virginia, Cantini, Marco, González-García, Cristina, Cheng, Zhe A, Yang, Jingli, Tsimbouri, Penelope M, García, Andrés J, Dalby, Matthew J, Salmerón-Sánchez, Manuel

“…Growth factors (GFs) are powerful signaling molecules with the potential to drive regenerative strategies, including bone repair and vascularization. However,…”
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Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor by Tsimbouri, Penelope M., Childs, Peter G., Pemberton, Gabriel D., Yang, Jingli, Jayawarna, Vineetha, Orapiriyakul, Wich, Burgess, Karl, González-García, Cristina, Blackburn, Gavin, Thomas, Dilip, Vallejo-Giraldo, Catalina, Biggs, Manus J. P, Curtis, Adam S. G., Salmerón-Sánchez, Manuel, Reid, Stuart, Dalby, Matthew J.

“…Bone grafts are one of the most commonly transplanted tissues. However, autologous grafts are in short supply, and can be associated with pain and donor-site…”
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A nanostructured bacterial bioscaffold for the sustained bottom-up delivery of protein drugs by Seras-Franzoso, Joaquin, Peebo, Karl, Luis Corchero, José, Tsimbouri, Penelope M, Unzueta, Ugutz, Rinas, Ursula, Dalby, Matthew J, Vazquez, Esther, García-Fruitós, Elena, Villaverde, Antonio

“…Bacterial inclusion bodies (IBs) are protein-based, amyloidal nanomaterials that mechanically stimulate mammalian cell proliferation upon surface decoration…”
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