A Laboratory Facility for the Controlled Exposure of Blood Vessels to High-Intensity Focused Ultrasound

A Laboratory Facility for the Controlled Exposure of Blood Vessels to High-Intensity Focused Ultrasound

A laboratory facility for the controlled exposure of blood vessels to high_intensity focused ultrasound (HIFU) is described. The facility comprises units for fixing and positioning of the object of study, ultrasound scanning, targeting, and exposure to limited doses of HIFU. The ultrasonic unit impl...

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Bibliographic Details
Published in:Biomedical engineering Vol. 50; no. 2; pp. 96 - 99
Main Authors: Berkovich, A. E., Bursian, A. A., Senchik, K. U., Petrishchev, N. N., Tsibin, A. U., Yukina, G. U.
Format: Journal Article
Language:English
Published: New York Springer US 01-07-2016
Springer
Springer Nature B.V
Subjects:
Animal experimentation
Biomaterials
Biomedical Engineering and Bioengineering
Blood vessels
Calibration
Collagen
Collagens
Engineering
Exposure
Femur
In vivo methods and tests
Laboratories
Rabbits
Scanning
Ultrasonic imaging
Ultrasonic processing
Ultrasonic treatment
Ultrasound
Veins
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Description
Summary:A laboratory facility for the controlled exposure of blood vessels to high_intensity focused ultrasound (HIFU) is described. The facility comprises units for fixing and positioning of the object of study, ultrasound scanning, targeting, and exposure to limited doses of HIFU. The ultrasonic unit implements the functions of targeting and ultrasonic treatment. The ultrasound generator was calibrated. The effect of HIFU exposure on the femoral veins was investigated in in vivo experiments on animals (rabbits). An ultrasound intensity of ~8.7 kW/cm 2 at the focal spot led to structural changes in all layers of the vein wall, the most significant of the changes being endothelial desquamation and the disorganization of collagen. These changes formed the basis for subsequent obliteration.
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ISSN:0006-3398
1573-8256
DOI:10.1007/s10527-016-9596-0