Subgroups of primary Sjögren’s syndrome. Sjögren’s syndrome in male and paediatric Greek patients

OBJECTIVES To describe the clinical and serological findings in male and paediatric Sjögren’s syndrome (SS) patients. PATIENTS AND METHODS Using the European criteria for the diagnosis of SS 12 male and 13 paediatric patients were identified and compared with those of 30 consecutive unselected adult...

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Bibliographic Details
Published in:	Annals of the rheumatic diseases Vol. 56; no. 5; pp. 333 - 335
Main Authors:	Drosos, Alexandros A, Tsiakou, Eleni K, Tsifetaki, Niki, Politi, Eudokia N, Siamopoulou-Mavridou, Antigoni
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group Ltd and European League Against Rheumatism 01-05-1997 BMJ BMJ Publishing Group LTD
Subjects:	Adolescent Adult Age Factors Antibodies Antibodies, Antinuclear - blood Antigens Arthritis Arthritis - pathology Biological and medical sciences Biopsy Child children Concise Reports Diseases of eyelid, conjunctiva and lacrimal tracts Exocrine glands Female Greece Humans Immunology Male Medical sciences Men Ophthalmology parotid gland Parotid Gland - pathology Pediatrics Prevalence Raynaud disease Raynaud Disease - pathology Sarcoidosis Serology Sex Factors Sjogren's Syndrome - complications Sjogren's Syndrome - diagnosis Sjogren's Syndrome - immunology Sjögren’s syndrome Greece Europe Human Immunopathology Seropositivity Stomatology Autoantibody Autoimmune disease Epidemiology Sjögren syndrome Incidence Assay Symptomatology Eye disease Age of onset Systemic disease Public health
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Summary:	OBJECTIVES To describe the clinical and serological findings in male and paediatric Sjögren’s syndrome (SS) patients. PATIENTS AND METHODS Using the European criteria for the diagnosis of SS 12 male and 13 paediatric patients were identified and compared with those of 30 consecutive unselected adult female SS patients. RESULTS The mean (SD) age of paediatric patients was 9.4 (2.2) years, ranging from 6 to 14 years. Recurrent parotid gland enlargement was the initial clinical manifestation in the majority of the children with a statistical significance compared with male (p<0.01) and with female patients (p<0.0001). Sicca manifestations were the most common clinical symptoms in male and female patients at disease onset. The systemic manifestations were similar among the three groups except that men showed lower frequency of arthritis (p<0.05) and Raynaud’s phenomenon (p<0.05) compared with women. No differences were found among the immunological profile of children and female patients, while male patients had a lower frequency of antinuclear antibodies (p<0.025) and antibodies to Ro(SSA) nuclear antigens (p<0.025) compared with women. CONCLUSION Primary SS is rare in children and men in Greece. Recurrent parotid gland enlargement is the most common clinical finding at disease onset in children. Male patients seem to have less systemic manifestations and lower frequency of autoantibodies.
Bibliography:	Dr A A Drosos, Department of Internal Medicine, Medical School,University of Ioannina, 45110 Ioannina, Greece. ark:/67375/NVC-8QP6RFCZ-K local:annrheumdis;56/5/333 istex:56CD33E40C285F16840B3985230A109FA90BDAE8 PMID:9175937 href:annrheumdis-56-333.pdf ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-4967 1468-2060
DOI:	10.1136/ard.56.5.333