Search Results - "Tsiailanis, Antonis D"
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Development of FluoAHRL: A Novel Synthetic Fluorescent Compound That Activates AHR and Potentiates Anti-Inflammatory T Regulatory Cells
Published in Molecules (Basel, Switzerland) (23-06-2024)“…Aryl Hydrocarbon Receptor (AHR) ligands, upon binding, induce distinct gene expression profiles orchestrated by the AHR, leading to a spectrum of pro- or…”
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Chemical Profiling, Bioactivity Evaluation and the Discovery of a Novel Biopigment Produced by Penicillium purpurogenum CBS 113139
Published in Molecules (Basel, Switzerland) (23-12-2021)“…Biobased pigments are environmentally friendly alternatives to synthetic variants with an increased market demand. Production of pigments via fermentation is a…”
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Biophysical Evaluation and In Vitro Controlled Release of Two Isomeric Adamantane Phenylalkylamines with Antiproliferative/Anticancer and Analgesic Activity
Published in Molecules (Basel, Switzerland) (21-12-2021)“…The aqueous dissolution profile of the isomeric synthetic adamantane phenylalkylamine hydrochlorides and was probed. These adducts have shown significant…”
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Encapsulation of Temozolomide in a Calixarene Nanocapsule Improves Its Stability and Enhances Its Therapeutic Efficacy against Glioblastoma
Published in Molecular cancer therapeutics (01-09-2019)“…The alkylating agent temozolomide (TMZ) is the first-line chemotherapeutic for glioblastoma (GBM), a common and aggressive primary brain tumor in adults…”
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Encapsulation of Small Drugs in a Supramolecule Enhances Solubility, Stability, and Therapeutic Efficacy Against Glioblastoma Multiforme
Published in Methods in molecular biology (Clifton, N.J.) (2021)“…Cancer occupies a high rank in the global morbidity and mortality scale with glioblastoma multiforme (GBM) accounting for almost 80% of all primary tumors of…”
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Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid
Published in Free radical biology & medicine (20-11-2020)“…Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Maximal surgical resection followed by radiotherapy and…”
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Exploiting the beneficial effects of Salvia officinalis L. extracts in human health and assessing their activity as potent functional regulators of food microbiota
Published in Food chemistry (30-05-2024)“…•The phytochemical profile of S. officinalis unveiled 103 secondary metabolites.•Significant antimicrobial activity against pathogenic microbes was noted by S…”
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Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability
Published in Bioorganic & medicinal chemistry letters (01-07-2021)“…[Display omitted] The Renin-Angiotensin System (RAS) plays a crucial role in numerous pathological conditions. Two of the critical RAS players, the angiotensin…”
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Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma
Published in Proceedings of the National Academy of Sciences - PNAS (09-08-2022)“…Glioblastoma (GBM) is an aggressive malignant primary brain tumor with limited therapeutic options. We show that the angiotensin II (AngII) type 2 receptor…”
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Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma
Published in Proceedings of the National Academy of Sciences - PNAS (09-08-2022)“…Glioblastoma (GBM) is an aggressive malignant primary brain tumor with limited therapeutic options. We show that the angiotensin II (AngII) type 2 receptor (AT…”
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Development of a DHA-Losartan hybrid as a potent inhibitor of multiple pathway-induced platelet aggregation
Published in Journal of biomolecular structure & dynamics (01-01-2022)“…Despite the scientific progression in the prevention and treatment of cardiovascular diseases (CVDs) they remain the leading cause of mortality and disability…”
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Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL
Published in Organic & biomolecular chemistry (26-09-2017)“…Anti-apoptotic proteins, like the Bcl-2 family proteins, present an important therapeutic cancer drug target. Their activity is orchestrated through…”
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