Search Results - "Tsia, Kevin K."

Kilohertz two-photon fluorescence microscopy imaging of neural activity in vivo by Wu, Jianglai, Liang, Yajie, Chen, Shuo, Hsu, Ching-Lung, Chavarha, Mariya, Evans, Stephen W., Shi, Dongqing, Lin, Michael Z., Tsia, Kevin K., Ji, Na

“…Understanding information processing in the brain requires monitoring neuronal activity at high spatiotemporal resolution. Using an ultrafast two-photon…”
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Toward Deep Biophysical Cytometry: Prospects and Challenges by Lee, Kelvin C.M., Guck, Jochen, Goda, Keisuke, Tsia, Kevin K.

“…The biophysical properties of cells reflect their identities, underpin their homeostatic state in health, and define the pathogenesis of disease. Recent…”
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PARC: ultrafast and accurate clustering of phenotypic data of millions of single cells by Stassen, Shobana V, Siu, Dickson M D, Lee, Kelvin C M, Ho, Joshua W K, So, Hayden K H, Tsia, Kevin K

“…Abstract Motivation New single-cell technologies continue to fuel the explosive growth in the scale of heterogeneous single-cell data. However, existing…”
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Generalized and scalable trajectory inference in single-cell omics data with VIA by Stassen, Shobana V., Yip, Gwinky G. K., Wong, Kenneth K. Y., Ho, Joshua W. K., Tsia, Kevin K.

“…Inferring cellular trajectories using a variety of omic data is a critical task in single-cell data science. However, accurate prediction of cell fates, and…”
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Performance of serial time-encoded amplified microscope by Tsia, Kevin K, Goda, Keisuke, Capewell, Dale, Jalali, Bahram

“…Serial time-encoded amplified microscopy (STEAM) is an entirely new imaging modality that enables ultrafast continuous real-time imaging with high sensitivity…”
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High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser by Kong, Cihang, Pilger, Christian, Hachmeister, Henning, Wei, Xiaoming, Cheung, Tom H., Lai, Cora S. W., Lee, Nikki P., Tsia, Kevin. K., Wong, Kenneth K. Y., Huser, Thomas

“…Coherent Raman scattering (CRS) microscopy is widely recognized as a powerful tool for tackling biomedical problems based on its chemically specific label-free…”
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102-nm, 44.5-MHz inertial-free swept source by mode-locked fiber laser and time stretch technique for optical coherence tomography by Kang, Jiqiang, Feng, Pingping, Wei, Xiaoming, Lam, Edmund Y, Tsia, Kevin K, Wong, Kenneth K Y

“…A swept source with both high repetition-rate and broad bandwidth is indispensable to enable optical coherence tomography (OCT) with high imaging rate and high…”
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StaVia: spatially and temporally aware cartography with higher-order random walks for cell atlases by Stassen, Shobana V, Kobashi, Minato, Lam, Edmund Y, Huang, Yuanhua, Ho, Joshua W K, Tsia, Kevin K

“…Single-cell atlases pose daunting computational challenges pertaining to the integration of spatial and temporal information and the visualization of…”
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Optofluidic imaging meets deep learning: from merging to emerging by Siu, Dickson M D, Lee, Kelvin C M, Chung, Bob M F, Wong, Justin S J, Zheng, Guoan, Tsia, Kevin K

“…Propelled by the striking advances in optical microscopy and deep learning (DL), the role of imaging in lab-on-a-chip has dramatically been transformed from a…”
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Quantitative Phase Imaging Flow Cytometry for Ultra‐Large‐Scale Single‐Cell Biophysical Phenotyping by Lee, Kelvin C.M., Wang, Maolin, Cheah, Kathryn S.E., Chan, Godfrey C.F., So, Hayden K.H., Wong, Kenneth K.Y., Tsia, Kevin K.

“…ABSTRACT Cellular biophysical properties are the effective label‐free phenotypes indicative of differences in cell types, states, and functions. However,…”
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EuniceScope: Low-cost imaging platform for studying microgravity cell biology by Chu, Wing Yan, Tsia, Kevin K.

“…Microgravity is proven to impact a wide range of human physiology, from stimulating stem cell differentiation to confounding cell health in bones, skeletal…”
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Ultrafast laser-scanning time-stretch imaging at visible wavelengths by Wu, Jiang-Lai, Xu, Yi-Qing, Xu, Jing-Jiang, Wei, Xiao-Ming, Chan, Antony CS, Tang, Anson HL, Lau, Andy KS, Chung, Bob MF, Cheung Shum, Ho, Lam, Edmund Y, Wong, Kenneth KY, Tsia, Kevin K

“…Optical time-stretch imaging enables the continuous capture of non-repetitive events in real time at a line-scan rate of tens of MHz—a distinct advantage for…”
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Breathing laser as an inertia-free swept source for high-quality ultrafast optical bioimaging by Wei, Xiaoming, Xu, Jingjiang, Xu, Yiqing, Yu, Luoqin, Xu, Jianbing, Li, Bowen, Lau, Andy K S, Wang, Xie, Zhang, Chi, Tsia, Kevin K, Wong, Kenneth K Y

“…We demonstrate an all-fiber breathing laser as inertia-free swept source (BLISS), with an ultra-compact design, for the emerging ultrafast bioimaging…”
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High-throughput time-stretch imaging flow cytometry for multi-class classification of phytoplankton by Lai, Queenie T K, Lee, Kelvin C M, Tang, Anson H L, Wong, Kenneth K Y, So, Hayden K H, Tsia, Kevin K

“…Time-stretch imaging has been regarded as an attractive technique for high-throughput imaging flow cytometry primarily owing to its real-time, continuous…”
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Video-rate centimeter-range optical coherence tomography based on dual optical frequency combs by electro-optic modulators by Kang, Jiqiang, Feng, Pingping, Li, Bowen, Zhang, Chi, Wei, Xiaoming, Lam, Edmund Y, Tsia, Kevin K, Wong, Kenneth K Y

“…Imaging speed and range are two important parameters for optical coherence tomography (OCT). A conventional video-rate centimeter-range OCT requires an optical…”
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Spectral-temporal dynamics of multipulse mode-locking by Yu, Ying, Li, Bowen, Wei, Xiaoming, Xu, Yiqing, Tsia, Kevin K. M., Wong, Kenneth K. Y.

“…In addition to stable pulse generation, passively mode-locked fiber lasers can easily run into an unstable regime of multipulse mode-locking. The birth and…”
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Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow by Wong, Terence T. W., Lau, Andy K. S., Ho, Kenneth K. Y., Tang, Matthew Y. H., Robles, Joseph D. F., Wei, Xiaoming, Chan, Antony C. S., Tang, Anson H. L., Lam, Edmund Y., Wong, Kenneth K. Y., Chan, Godfrey C. F., Shum, Ho Cheung, Tsia, Kevin K.

“…Accelerating imaging speed in optical microscopy is often realized at the expense of image contrast, image resolution and detection sensitivity – a common…”
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Serial time-encoded amplified microscopy (STEAM) based on a stabilized picosecond supercontinuum source by Zhang, Chi, Qiu, Yi, Zhu, Rui, Wong, Kenneth K Y, Tsia, Kevin K

“…Temporal stability of the broadband source, such as supercontinuum (SC), is the key enabling factor for realizing high performance ultrafast serial…”
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High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch by Xu, Jingjiang, Wei, Xiaoming, Yu, Luoqin, Zhang, Chi, Xu, Jianbing, Wong, K K Y, Tsia, Kevin K

“…As the key prerequisite of high-speed volumetric structural and functional tissue imaging in real-time, scaling the A-scan rate beyond MHz has been one of the…”
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Spectral period doubling and encoding of dissipative optical solitons via gain control by Yang, Kangwen, Zhou, Yi, Ling, Yuqing, Tsia, Kevin K., Zeng, Heping, Wong, Kenneth K. Y.

“…Period-doubling bifurcation, as an intermediate state between order and chaos, is ubiquitous in all disciplines of nonlinear science. However, previous…”
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