Search Results - "Tshilwane, S I"

A multi-epitope DNA vaccine co-administered with monophosphoryl lipid A adjuvant provides protection against tick transmitted Ehrlichia ruminantium in sheep by Tshilwane, S.I., Thema, N., Steyn, H.C., van Kleef, M., Pretorius, A.

“…•E. ruminantium peptides formulated in multi-epitope DNA vaccine constructs induced Th1 immunity in vitro.•pLamp multi-epitope DNA vaccine construct induced…”
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Preliminary insights on the metabolomics of Trichinella zimbabwensis infection in Sprague Dawley rats using GCxGC-TOF-MS (untargeted approach) by Ndlovu, I S, Silas, Ekuyikeno, Tshilwane, S I, Chaisi, M, Vosloo, A, Mukaratirwa, S

“…infections have been documented globally and have been detected in wild and/or domestic animals except Antarctica. There is paucity of information in the…”
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African horse sickness virus serotype 4 antigens, VP1-1, VP2-2, VP4, VP7 and NS3, induce cytotoxic T cell responses in vitro by Faber, F.E., van Kleef, M., Tshilwane, S.I., Pretorius, A.

“…•Optimised the FATT-CTL assay for use with horse PBMC.•Antigen-specific CD8+ T cells were detected against VP1-1, VP2-2, VP4, VP7 and NS3.•Cell lysis was…”
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Identification and characterisation of conserved epitopes of E. ruminantium that activate Th1 CD4+ T cells: Towards the development of a multi-epitope vaccine by Thema, N., Tshilwane, S.I., Pretorius, A., Son, L., Smith, R.M., Steyn, H.C., Liebenberg, J., van Kleef, M.

“…•Recombinant proteins induced IFN-γ production and other Th1 cytokines.•Peptides induced IFN-γ production and activation of memory CD4+ T cells.•Promising…”
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Ehrlichia ruminantium antigens and peptides induce cytotoxic T cell responses in vitro by Thema, N., Tshilwane, S.I., Son, L., Smith, R.M., Faber, F.E., Steyn, H.C., van Kleef, M., Liebenberg, J., Pretorius, A.

“…•Optimised FATT-CTL assay for the first time for sheep PBMC.•FATT-CTL assay was used to identify peptides that induced CTL.•Peptides from different antigens…”
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