Search Results - "Tsfadia, Yossi"

Molecular insights on the coronavirus MERS-CoV interaction with the CD26 receptor by Failayev, Hila, Ganoth, Assaf, Tsfadia, Yossi

“…•MERS-CoV remains a significant public health threat despite its discovery more than a decade ago. The study provides molecular insights into the interaction…”
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Extracellular mutation induces an allosteric effect across the membrane and hampers the activity of MRP1 (ABCC1) by Bin Kanner, Yuval, Ganoth, Assaf, Tsfadia, Yossi

“…Dynamic conformational changes play a major role in the function of proteins, including the ATP-Binding Cassette (ABC) transporters. Multidrug Resistance…”
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A dual and conflicting role for imiquimod in inflammation: A TLR7 agonist and a cAMP phosphodiesterase inhibitor by Ernst, Orna, Failayev, Hila, Athamna, Muhammad, He, Haoming, Tsfadia, Yossi, Zor, Tsaffrir

“…[Display omitted] The Toll-like receptor 7 (TLR7) agonist imiquimod is an antitumor and antiviral drug used for the treatment of skin indications such as basal…”
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Cytotoxicity and reversal effect of sertraline, fluoxetine, and citalopram on MRP1- and MRP7-mediated MDR by Bin Kanner, Yuval, Teng, Qiu-Xu, Ganoth, Assaf, Peer, Dan, Wang, Jing-Quan, Chen, Zhe-Sheng, Tsfadia, Yossi

“…Cancer is one of the leading causes of death worldwide, and the development of resistance to chemotherapy drugs is a major challenge in treating malignancies…”
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The Interaction of FABP with Kapα by Amber-Vitos, Ortal, Kucherenko, Nataly, Nachliel, Esther, Gutman, Menachem, Tsfadia, Yossi

“…Gene-activating lipophilic compounds are carried into the nucleus when loaded on fatty-acid-binding proteins (FABP). Some of these proteins are recognized by…”
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A single disulfide bond disruption in the β3 integrin subunit promotes thiol/disulfide exchange, a molecular dynamics study by Levin, Lihie, Zelzion, Ehud, Nachliel, Esther, Gutman, Menachem, Tsfadia, Yossi, Einav, Yulia

“…The integrins are a family of membrane receptors that attach a cell to its surrounding and play a crucial function in cell signaling. The combination of…”
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Tracking the interplay between bound peptide and the lid domain of DnaK, using molecular dynamics by Azoulay, Itzhaq, Kucherenko, Nataly, Nachliel, Esther, Gutman, Menachem, Azem, Abdussalam, Tsfadia, Yossi

“…Hsp70 chaperones consist of two functional domains: the 44 kDa Nucleotide Binding Domain (NBD), that binds and hydrolyses ATP, and the 26 kDa Substrate Binding…”
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Structure-guided probing of the leukotriene C 4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1) by Conseil, Gwenaëlle, Arama-Chayoth, May, Tsfadia, Yossi, Cole, Susan P C

“…The human multidrug resistance protein 1 (hMRP1) transporter is implicated in cancer multidrug resistance as well as immune responses involving its physiologic…”
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The effect of regulating molecules on the structure of the PPAR-RXR complex by Amber-Vitos, Ortal, Chaturvedi, Navaneet, Nachliel, Esther, Gutman, Menachem, Tsfadia, Yossi

“…The PPAR-RXR complex is one of the most significant and prevalent regulatory systems, controlling lipid metabolism by gene expression. Both proteins are…”
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Structure‐guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1) by Conseil, Gwenaëlle, Arama-Chayoth, May, Tsfadia, Yossi, Cole, Susan P. C.

“…ABSTRACT The human multidrug resistance protein 1 (hMRP1) transporter is implicated in cancer multidrug resistance as well as immune responses involving its…”
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Ubiquitin: Molecular modeling and simulations by Ganoth, Assaf, Tsfadia, Yossi, Wiener, Reuven

“…•Ubiquitin plays a vital role not only in protein degradation but also in many other cellular functions.•Deciphering the dynamics and complexity of ubiquitin…”
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Functional reconstitution of the MERS CoV receptor binding motif by Uppalapati, Lakshminarasaiah, Roitburd-Berman, Anna, Weiss-Ottolenghi, Yael, Graham, Barney S., Dimitrov, Dimiter S., Ying, Tianlei, Failayev, Hila, Tsfadia, Yossi, Gershoni, Jonathan M.

“…In the early 1960’s the first human coronaviruses (designated 229E and OC43) were identified as etiologic agents of the common cold, to be followed by the…”
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From virus to diabetes therapy: Characterization of a specific insulin‐degrading enzyme inhibitor for diabetes treatment by Nash, Yuval, Ganoth, Assaf, Borenstein‐Auerbach, Nofit, Levy‐Barazany, Hilit, Goldsmith, Guy, Kopelevich, Adi, Pozyuchenko, Katia, Sakhneny, Lina, Lazdon, Ekaterina, Blanga‐Kanfi, Shani, Alhadeff, Raphael, Benromano, Tali, Landsman, Limor, Tsfadia, Yossi, Frenkel, Dan

“…Inhibition of insulin‐degrading enzyme (IDE) is a possible target for treating diabetes. However, it has not yet evolved into a medical intervention, mainly…”
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An Outward-Facing Aromatic Amino Acid Is Crucial for Signaling between the Membrane-Spanning and Nucleotide-Binding Domains of Multidrug Resistance Protein 1 (MRP1; ABCC1) by Weigl, Kevin E, Conseil, Gwenaëlle, Rothnie, Alice J, Arama, May, Tsfadia, Yossi, Cole, Susan P C

“…The 190-kDa human MRP1 is an ATP-binding cassette multidrug and multiorganic anion efflux transporter. The 17 transmembrane helices of its three…”
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The involvement of coordinative interactions in the binding of dihydrolipoamide dehydrogenase to titanium dioxide—Localization of a putative binding site by Dayan, Avraham, Babin, Gilad, Ganoth, Assaf, Kayouf, Nivin Samir, Nitoker Eliaz, Neta, Mukkala, Srijana, Tsfadia, Yossi, Fleminger, Gideon

“…Titanium (Ti) and its alloys are widely used in orthodontic and orthopedic implants by virtue to their high biocompatibility, mechanical strength, and high…”
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The Translocation of Na+ Ion Inside Human Thrombin Accounts for the Activation of the Enzyme by Gdalya, Hagit, Nachliel, Esther, Gutman, Menachem, Einav, Yulia, Tsfadia, Yossi

“…Thrombin is a member of the chymotrypsin family that splits the peptide bond next to arginine. The catalytic activity of thrombin is accelerated by Na+…”
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The Interaction of FABP with Kap[alpha] by Amber-Vitos, Ortal, Kucherenko, Nataly, Nachliel, Esther, Gutman, Menachem, Tsfadia, Yossi

“…Gene-activating lipophilic compounds are carried into the nucleus when loaded on fatty-acid-binding proteins (FABP). Some of these proteins are recognized by…”
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Correction: A Single Disulfide Bond Disruption in the β3 Integrin Subunit Promotes Thiol/Disulfide Exchange, a Molecular Dynamics Study by Levin, Lihie, Zelzion, Ehud, Nachliel, Esther, Gutman, Menachem, Tsfadia, Yossi, Einav, Yulia

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Interaction of the Tim44 C-Terminal Domain with Negatively Charged Phospholipids by Marom, Milit, Safonov, Roman, Amram, Shay, Avneon, Yoav, Nachliel, Esther, Gutman, Menachem, Zohary, Keren, Azem, Abdussalam, Tsfadia, Yossi

“…The translocation of proteins from the cytosol into the mitochondrial matrix is mediated by the coordinated action of the TOM complex in the outer membrane, as…”
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A Single Disulfide Bond Disruption in the [beta]3 Integrin Subunit Promotes Thiol/Disulfide Exchange, a Molecular Dynamics Study by Levin, Lihie, Zelzion, Ehud, Nachliel, Esther, Gutman, Menachem, Tsfadia, Yossi, Einav, Yulia

“…The integrins are a family of membrane receptors that attach a cell to its surrounding and play a crucial function in cell signaling. The combination of…”
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