Search Results - "Tsemakhovich, Vladimir"

Dual regulation of G proteins and the G-protein–activated K⁺ channels by lithium by Tselnicker, Isabella Farhy, Tsemakhovich, Vladimir, Rishal, Ida, Kahanovitch, Uri, Dessauer, Carmen W., Dascal, Nathan

“…Lithium (Li ⁺) is widely used to treat bipolar disorder (BPD). Cellular targets of Li ⁺, such as glycogen synthase kinase 3β (GSK3β) and G proteins, have long…”
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Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels by Reddy, Haritha P., Yakubovich, Daniel, Keren-Raifman, Tal, Tabak, Galit, Tsemakhovich, Vladimir A., Pedersen, Maria H., Shalomov, Boris, Colombo, Sophie, Goldstein, David B., Javitch, Jonathan A., Bera, Amal K., Dascal, Nathan

“…Mutations in the GNB1 gene, encoding the Gβ1 subunit of heterotrimeric G proteins, cause GNB1 Encephalopathy. Patients experience seizures, pointing to…”
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Haptoglobin Phenotypes Differ in Their Ability To Inhibit Heme Transfer from Hemoglobin to LDL by Bamm, Vladimir V, Tsemakhovich, Vladimir A, Shaklai, Matityahu, Shaklai, Nurith

“…LDL oxidation plays a pivotal role in atherosclerosis. Excellular hemoglobin (Hb) is a trigger of LDL oxidation. By virtue of its ability to bind hemoglobin,…”
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Stargazin Modulates Neuronal Voltage-dependent Ca2+ Channel Cav2.2 by a Gβγ-dependent Mechanism by Tselnicker, Isabella, Tsemakhovich, Vladimir A., Dessauer, Carmen W., Dascal, Nathan

“…Loss of neuronal protein stargazin (γ2) is associated with recurrent epileptic seizures and ataxia in mice. Initially, due to homology to the skeletal muscle…”
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Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits by Berlin, Shai, Tsemakhovich, Vladimir A, Castel, Ruth, Ivanina, Tatiana, Dessauer, Carmen W, Keren-Raifman, Tal, Dascal, Nathan

“…G protein-activated K(+) channels (Kir3 or GIRK) are activated by direct interaction with Gβγ. Gα is essential for specific signaling and regulates basal…”
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Mechanism of Low-Density Lipoprotein Oxidation by Hemoglobin-Derived Iron by Grinshtein, Natalie, Bamm, Vladimir Varlen, Tsemakhovich, Vladimir Abraham, Shaklai, Nurith

“…Excellular hemoglobin is an extremely active oxidant of low-density lipoproteins (LDL), a phenomenon explained so far by different mechanisms. In this study,…”
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Reconstitution of β-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms by Katz, Moshe, Subramaniam, Suraj, Chomsky-Hecht, Orna, Tsemakhovich, Vladimir, Flockerzi, Veit, Klussmann, Enno, Hirsch, Joel A., Weiss, Sharon, Dascal, Nathan

“…L-type voltage-gated CaV1.2 channels crucially regulate cardiac muscle contraction. Activation of β-adrenergic receptors (β-AR) augments contraction via…”
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Ggamma Assists Gbeta to Activate GIRK1 by Relaxing Inhibitory Constraint by Tabak, Galit, Keren Raifman, Tal, Tsemakhovich, Vladimir, Dascal, Nathan

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Reconstitution of β-adrenergic regulation of Ca V 1.2: Rad-dependent and Rad-independent protein kinase A mechanisms by Katz, Moshe, Subramaniam, Suraj, Chomsky-Hecht, Orna, Tsemakhovich, Vladimir, Flockerzi, Veit, Klussmann, Enno, Hirsch, Joel A, Weiss, Sharon, Dascal, Nathan

“…L-type voltage-gated Ca 1.2 channels crucially regulate cardiac muscle contraction. Activation of β-adrenergic receptors (β-AR) augments contraction via…”
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Gβγ Activates GIRK2 with Low-Micromolar Affinity with Distinct Activation Pattern Compared to GIRK1/2 by Yakubovich, Daniel, Kahanovitch, Uri, Tabak, Galit, Keren Raifman, Tal, Tsemakhovich, Vladimir, Ranjan Tripathy, Debi, Dessauer, Carmen W., Hirsch, Joel A., Dascal, Nathan

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Recruitment of G beta gamma controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1 by Kahanovitch, Uri, Tsemakhovich, Vladimir, Berlin, Shai, Rubinstein, Moran, Styr, Boaz, Castel, Ruth, Peleg, Sagit, Tabak, Galit, Dessauer, Carmen W, Ivanina, Tatiana, Dascal, Nathan

“…The G-protein coupled inwardly rectifying potassium (GIRK) channel is an important mediator of neurotransmission via G beta gamma subunit of the heterotrimeric…”
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Direct Interaction Between N and C Termini of α1C Subunit of CaV1.2 L-Type Calcium Channel by Guggenheimer, Adva Benmocha, Almagor, Lior, Tsemakhovich, Vladimir, Ranjan Tripathy, Debi, Hirsch, Joel, Dascal, Nathan

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Recruitment of Gβγ controls the basal activity of G‐protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1 by Kahanovitch, Uri, Tsemakhovich, Vladimir, Berlin, Shai, Rubinstein, Moran, Styr, Boaz, Castel, Ruth, Peleg, Sagit, Tabak, Galit, Dessauer, Carmen W., Ivanina, Tatiana, Dascal, Nathan

“…Key points The G‐protein coupled inwardly rectifying potassium (GIRK) channel is an important mediator of neurotransmission via Gβγ subunit of the…”
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Two Distinct Aspects of Coupling between Gαi Protein and G Protein-activated K+ Channel (GIRK) Revealed by Fluorescently Labeled Gαi3 Protein Subunits by Berlin, Shai, Tsemakhovich, Vladimir A., Castel, Ruth, Ivanina, Tatiana, Dessauer, Carmen W., Keren-Raifman, Tal, Dascal, Nathan

“…G protein-activated K+ channels (Kir3 or GIRK) are activated by direct interaction with Gβγ. Gα is essential for specific signaling and regulates basal…”
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Dual Regulation of G Proteins and the G Protein-Activated Potassium Channels (GIRK) by Lithium by Tselnicker, Isabella Farhy, Tsemakhovich, Vladimir, Rishal, Ida, Dessauer, Carmen W., Dascal, Nathan

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Deficient Regulation of Gbetagamma Effectors by Fluorescently Labeled Galpha i3 Subunits Reveals Distinct Aspects of Coupling to GIRK and Cav2.2 Channels by Berlin, Shai, Tsemakhovich, Vladimir, Dessauer, Carmen W., Dascal, Nathan

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Recruitment of G[beta][gamma] controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1 by Kahanovitch, Uri, Tsemakhovich, Vladimir, Berlin, Shai, Rubinstein, Moran, Styr, Boaz, Castel, Ruth, Peleg, Sagit, Tabak, Galit, Dessauer, Carmen W, Ivanina, Tatiana, Dascal, Nathan

“…Key points The G-protein coupled inwardly rectifying potassium (GIRK) channel is an important mediator of neurotransmission via G[beta][gamma] subunit of the…”
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Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca(2+) channel by Benmocha Guggenheimer, Adva, Almagor, Lior, Tsemakhovich, Vladimir, Tripathy, Debi Ranjan, Hirsch, Joel A, Dascal, Nathan

“…The modulation and regulation of voltage-gated Ca(2+) channels is affected by the pore-forming segments, the cytosolic parts of the channel, and interacting…”
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Stargazin Modulates Neuronal Voltage-dependent Ca2+ Channel Cav2.2 by a Gbg-dependent Mechanism by Tselnicker, Isabella, Tsemakhovich, Vladimir A, Dessauer, Carmen W, Dascal, Nathan

“…Loss of neuronal protein stargazin (g sub(2)) is associated with recurrent epileptic seizures and ataxia in mice. Initially, due to homology to the skeletal…”
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Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca2+ channel by Benmocha Guggenheimer, Adva, Almagor, Lior, Tsemakhovich, Vladimir, Tripathy, Debi Ranjan, Hirsch, Joel A, Dascal, Nathan

“…The modulation and regulation of voltage-gated Ca 2+ channels is affected by the pore-forming segments, the cytosolic parts of the channel, and interacting…”
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