Search Results - "Tselios, Theodore"

Multiple Sclerosis: Immunopathology and Treatment Update by Dargahi, Narges, Katsara, Maria, Tselios, Theodore, Androutsou, Maria-Eleni, de Courten, Maximilian, Matsoukas, John, Apostolopoulos, Vasso

“…The treatment of multiple sclerosis (MS) has changed over the last 20 years. All immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still…”
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Gonadotropin-Releasing Hormone and GnRH Receptor: Structure, Function and Drug Development by Tzoupis, Haralambos, Nteli, Agathi, Androutsou, Maria-Eleni, Tselios, Theodore

“…Gonadotropin-Releasing Hormone (GnRH) is a key element in sexual maturation and regulation of the reproductive cycle in the human organism. GnRH interacts with…”
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Spontaneous human CD8 T cell and autoimmune encephalomyelitis-induced CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB115-positive multiple sclerosis humanized immune system mice by Papazian, Irini, Kourouvani, Maria, Dagkonaki, Anastasia, Gouzouasis, Vasileios, Dimitrakopoulou, Lila, Markoglou, Nikolaos, Badounas, Fotis, Tselios, Theodore, Anagnostouli, Maria, Probert, Lesley

“…Autoimmune diseases of the central nervous system (CNS) such as multiple sclerosis (MS) are only partially represented in current experimental models and the…”
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Cytotoxic Activity of Novel GnRH Analogs Conjugated with Mitoxantrone in Ovarian Cancer Cells by Markatos, Christos, Biniari, Georgia, Chepurny, Oleg G, Karageorgos, Vlasios, Tsakalakis, Nikos, Komontachakis, Georgios, Vlata, Zacharenia, Venihaki, Maria, Holz, George G, Tselios, Theodore, Liapakis, George

“…The gonadotropin-releasing hormone (GnRH) receptor (GnRH-R) is highly expressed in ovarian cancer cells (OCC), and it is an important molecular target for…”
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Design and Synthesis of Non-Peptide Mimetics Mapping the Immunodominant Myelin Basic Protein (MBP 83-96 ) Epitope to Function as T-Cell Receptor Antagonists by Yannakakis, Mary-Patricia, Simal, Carmen, Tzoupis, Haralambos, Rodi, Maria, Dargahi, Narges, Prakash, Monica, Mouzaki, Athanasia, Platts, James A, Apostolopoulos, Vasso, Tselios, Theodore V

“…Encephalitogenic T cells are heavily implicated in the pathogenesis of multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous…”
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IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity by Avloniti, Maria, Evangelidou, Maria, Gomini, Maria, Loupis, Theodore, Emmanouil, Mary, Mitropoulou, Adamantia, Tselios, Theodore, Lassmann, Hans, Gruart, Agnès, Delgado-García, José M, Probert, Lesley, Kyrargyri, Vasiliki

“…Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease characterized by motor deficits and cognitive decline. Many immune aspects of the disease…”
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Rational Design, Synthesis and Binding Affinity Studies of Anthraquinone Derivatives Conjugated to Gonadotropin-Releasing Hormone (GnRH) Analogues towards Selective Immunosuppression of Hormone-Dependent Cancer by Biniari, Georgia, Markatos, Christos, Nteli, Agathi, Tzoupis, Haralambos, Simal, Carmen, Vlamis-Gardikas, Alexios, Karageorgos, Vlasios, Pirmettis, Ioannis, Petrou, Panagiota, Venihaki, Maria, Liapakis, George, Tselios, Theodore

“…Gonadotropin-releasing hormone (GnRH) is pivotal in regulating human reproduction and fertility through its specific receptors. Among these,…”
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The Influence of Single Nucleotide Polymorphisms on Vitamin D Receptor Protein Levels and Function in Chronic Liver Disease by Tourkochristou, Evanthia, Tsounis, Efthymios P, Tzoupis, Haralampos, Aggeletopoulou, Ioanna, Tsintoni, Aggeliki, Lourida, Theoni, Diamantopoulou, Georgia, Zisimopoulos, Konstantinos, Kafentzi, Theodora, de Lastic, Anne-Lise, Rodi, Maria, Tselios, Theodore, Thomopoulos, Konstantinos, Mouzaki, Athanasia, Triantos, Christos

“…Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene have been associated with chronic liver disease. We investigated the role of VDR…”
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Maturation of circulating Ly6ChiCCR2+ monocytes by mannan-MOG induces antigen-specific tolerance and reverses autoimmune encephalomyelitis by Dagkonaki, Anastasia, Papalambrou, Athina, Avloniti, Maria, Gkika, Areti, Evangelidou, Maria, Androutsou, Maria-Eleni, Tselios, Theodore, Probert, Lesley

“…Autoimmune diseases affecting the CNS not only overcome immune privilege mechanisms that protect neural tissues but also peripheral immune tolerance mechanisms…”
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Distinct or Overlapping Areas of Mitochondrial Thioredoxin 2 May Be Used for Its Covalent and Strong Non-Covalent Interactions with Protein Ligands by Ntallis, Charalampos, Tzoupis, Haralampos, Tselios, Theodore, Chasapis, Christos T, Vlamis-Gardikas, Alexios

“…In silico approaches were employed to examine the characteristics of interactions between human mitochondrial thioredoxin 2 (HsTrx2) and its 38 previously…”
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A Cyclic Altered Peptide Analogue Based on Myelin Basic Protein 87-99 Provides Lasting Prophylactic and Therapeutic Protection Against Acute Experimental Autoimmune Encephalomyelitis by Emmanouil, Mary, Tseveleki, Vivian, Triantafyllakou, Iro, Nteli, Agathi, Tselios, Theodore, Probert, Lesley

“…In this report, amide-linked cyclic peptide analogues of the 87-99 myelin basic protein (MBP) epitope, a candidate autoantigen in multiple sclerosis (MS), are…”
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Characterization of Asparagine Deamidation in Immunodominant Myelin Oligodendrocyte Glycoprotein Peptide Potential Immunotherapy for the Treatment of Multiple Sclerosis by Androutsou, Maria-Eleni, Nteli, Agathi, Gkika, Areti, Avloniti, Maria, Dagkonaki, Anastasia, Probert, Lesley, Tselios, Theodore, Golič Grdadolnik, Simona

“…Mannan (polysaccharide) conjugated with a myelin oligodendrocyte glycoprotein (MOG) peptide, namely (KG) MOG , represents a potent and promising new approach…”
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Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions by Dagkonaki, Anastasia, Avloniti, Maria, Evangelidou, Maria, Papazian, Irini, Kanistras, Ioannis, Tseveleki, Vivian, Lampros, Fotis, Tselios, Theodore, Jensen, Lise Torp, Möbius, Wiebke, Ruhwedel, Torben, Androutsou, Maria-Eleni, Matsoukas, John, Anagnostouli, Maria, Lassmann, Hans, Probert, Lesley

“…CNS autoantigens conjugated to oxidized mannan (OM) induce antigen-specific T cell tolerance and protect mice against autoimmune encephalomyelitis (EAE). To…”
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Myelin Oligodendrocyte Glycoprotein and Multiple Sclerosis by Androutsou, Maria-Eleni, Tapeinou, Anthi, Vlamis-Gardikas, Alexios, Tselios, Theodore

“…Myelin oligodendrocyte glycoprotein (MOG) is located on the external surface of myelin, a membranous component of the central nervous system (CNS) that forms…”
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Use of the 2-chlorotrityl chloride resin for microwave-assisted solid phase peptide synthesis by Ieronymaki, Matthaia, Androutsou, Maria Eleni, Pantelia, Anna, Friligou, Irene, Crisp, Molly, High, Kirsty, Penkman, Kirsty, Gatos, Dimitrios, Tselios, Theodore

“…ABSTRACT A fast and efficient microwave (MW)‐assisted solid‐phase peptide synthesis protocol using the 2‐chlorotrityl chloride resin and the Fmoc/tBu…”
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Rational design and synthesis of altered peptide ligands based on human myelin oligodendrocyte glycoprotein 35-55 epitope: inhibition of chronic experimental autoimmune encephalomyelitis in mice by Tselios, Theodore, Aggelidakis, Mihalis, Tapeinou, Anthi, Tseveleki, Vivian, Kanistras, Ioannis, Gatos, Dimitrios, Matsoukas, John

“…Experimental autoimmune encephalomyelitis (EAE) is a demyelinating disease of the central nervous system and is an animal model of multiple sclerosis (MS)…”
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A novel synthetic luteinizing hormone-releasing hormone (LHRH) analogue coupled with modified β-cyclodextrin: Insight into its intramolecular interactions by Kordopati, Golfo G., Tselios, Theodore V., Kellici, Tahsin, Merzel, Franci, Mavromoustakos, Thomas, Grdadolnik, Simona Golic, Tsivgoulis, Gerasimos M.

“…Cyclodextrins (CDs) in combination with therapeutic proteins and other bioactive compounds have been proposed as candidates that show enhanced chemical and…”
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Microwave-assisted solid-phase peptide synthesis of the 60-110 domain of human pleiotrophin on 2-chlorotrityl resin by Friligou, Irene, Papadimitriou, Evangelia, Gatos, Dimitrios, Matsoukas, John, Tselios, Theodore

“…A fast and efficient microwave-assisted solid phase peptide synthesis (MW-SPPS) of a 51mer peptide, the main heparin-binding site (60-110) of human…”
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Biologically relevant conformational features of linear and cyclic proteolipid protein (PLP) peptide analogues obtained by high-resolution nuclear magnetic resonance and molecular dynamics by Kordopati, Golfo G., Tzoupis, Haralambos, Troganis, Anastassios N., Tsivgoulis, Gerasimos M., Golic Grdadolnik, Simona, Simal, Carmen, Tselios, Theodore V.

“…Proteolipid protein (PLP) is one of the main proteins of myelin sheath that are destroyed during the progress of multiple sclerosis (MS). The immunodominant…”
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Review cyclic peptides on a merry-go-round; towards drug design by Tapeinou, Anthi, Matsoukas, Minos-Timotheos, Simal, Carmen, Tselios, Theodore

“…ABSTRACT Peptides and proteins are attractive initial leads for the rational design of bioactive molecules. Several natural cyclic peptides have recently…”
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