Search Results - "Tsegay, Pawlos S"

Replication Stress and Consequential Instability of the Genome and Epigenome by Tsegay, Pawlos S, Lai, Yanhao, Liu, Yuan

“…Cells must faithfully duplicate their DNA in the genome to pass their genetic information to the daughter cells. To maintain genomic stability and integrity,…”
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5',8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance by Chatgilialoglu, Chryssostomos, Ferreri, Carla, Geacintov, Nicholas E, Krokidis, Marios G, Liu, Yuan, Masi, Annalisa, Shafirovich, Vladimir, Terzidis, Michael A, Tsegay, Pawlos S

“…Purine 5',8-cyclo-2'-deoxynucleosides (cPu) are tandem-type lesions observed among the DNA purine modifications and identified in mammalian cellular DNA in…”
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N6-Methyladenosine, DNA Repair, and Genome Stability by Qu, Fei, Tsegay, Pawlos S., Liu, Yuan

“…N 6 -methyladenosine (m 6 A) modification in mRNAs and non-coding RNAs is a newly identified epitranscriptomic mark. It provides a fine-tuning of gene…”
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Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase by Jiang, Zhongliang, Lai, Yanhao, Beaver, Jill M, Tsegay, Pawlos S, Zhao, Ming-Lang, Horton, Julie K, Zamora, Marco, Rein, Hayley L, Miralles, Frank, Shaver, Mohammad, Hutcheson, Joshua D, Agoulnik, Irina, Wilson, Samuel H, Liu, Yuan

“…DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular…”
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RNA-guided DNA base damage repair via DNA polymerase-mediated nick translation by Tsegay, Pawlos S, Hernandez, Daniela, Qu, Fei, Olatunji, Mustapha, Mamun, Yasir, Chapagain, Prem, Liu, Yuan

“…DNA repair is mediated by DNA synthesis guided by a DNA template. Recent studies have shown that DNA repair can also be accomplished by RNA-guided DNA…”
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N 6 -Methyladenosine, DNA Repair, and Genome Stability by Qu, Fei, Tsegay, Pawlos S, Liu, Yuan

“…N -methyladenosine (m A) modification in mRNAs and non-coding RNAs is a newly identified epitranscriptomic mark. It provides a fine-tuning of gene expression…”
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Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair by Tsegay, Pawlos S., Hernandez, Daniela, Brache, Christopher, Chatgilialoglu, Chryssostomos, Krokidis, Marios G., Chapagain, Prem, Liu, Yuan

“…5’,8-cyclo-2-deoxy nucleosides (cdPus) are the smallest tandem purine lesions including 5’,8-cyclo-2’-deoxyadenosine (cdA) and 5’,8-cyclo-2’-deoxyguanosine…”
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Brevetoxin induces a shift in the redox state of the proteome and unfolded protein response in human lymphoblast cells that can be alleviated with the acrolein scavenger MESNA by Jobson, Jordan, Tsegay, Pawlos S., Beltran, Mayra Tabares, Taher, Eman A., Rein, Samuel R., Liu, Yuan, Rein, Kathleen S.

“…Human lymphoblast cells were treated with the marine algal toxin, brevetoxin-2 (PbTx-2), and its effects on the proteome were assessed by redox proteomics…”
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Scanning Ion Conductance Microscopy Study Reveals the Disruption of the Integrity of the Human Cell Membrane Structure by Oxidative DNA Damage by Rubfiaro, Alberto S, Tsegay, Pawlos S, Lai, Yanhao, Cabello, Emmanuel, Shaver, Mohammad, Hutcheson, Joshua, Liu, Yuan, He, Jin

“…Oxidative stress can damage organs, tissues, and cells through reactive oxygen species (ROS) by oxidizing DNA, proteins, and lipids, thereby resulting in…”
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