Search Results - "Tsea, Ioanna"
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A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma
Published in Nature communications (30-09-2022)“…Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults. When ccRCC is localized to the kidney, surgical resection or…”
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Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma
Published in Molecular cancer (31-08-2024)“…Neuroblastoma (NB) is a heterogeneous embryonal malignancy and the deadliest tumor of infancy. It is a complex disease that can result in diverse clinical…”
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Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions
Published in Genome medicine (29-01-2024)“…Despite therapeutic advances, once a cancer has metastasized to the bone, it represents a highly morbid and lethal disease. One third of patients with advanced…”
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MDB-04. SINGLE-CELL TRANSCRIPTOMIC ANALYSIS REVEALS DISTINCT GENOMIC LANDSCAPES, CELL TRAJECTORIES, AND TUMOUR-MICROENVIRONMENT INTERACTIONS IN FOUR SUBTYPES OF MEDULLOBLASTOMA
Published in Neuro-oncology (Charlottesville, Va.) (12-06-2023)“…Abstract Medulloblastoma is the most common paediatric high-grade brain tumour, which comprises four different molecular subtypes (SHH, Wnt, Group 3, and Group…”
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Recent Advances in Single-Cell RNA-Sequencing of Primary and Metastatic Clear Cell Renal Cell Carcinoma
Published in Cancers (26-09-2023)“…Over the past two decades, significant progress has been made in the treatment of clear cell renal cell carcinoma (ccRCC), with a shift towards adopting new…”
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The ROCK-1/2 inhibitor RKI-1447 blocks N-MYC, promotes cell death, and emerges as a synergistic partner for BET inhibitors in neuroblastoma
Published in Cancer letters (28-11-2024)“…High-risk neuroblastoma has a poor prognosis despite intensive treatment, highlighting the need for new therapeutic strategies. Genetic alterations in…”
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Genomic tumour evolution dictates human medulloblastoma progression
Published in Neuro-oncology advances (05-10-2024)“…Abstract Background Medulloblastoma (MB) is the most common high-grade paediatric brain tumour, comprised of four main molecular subgroups – SHH, Wnt, Group 3,…”
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Abstract 1677: Transcriptomic landscape of medulloblastoma reveals pathways of tumor-stroma remodelling
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Medulloblastoma is one of the most common pediatric malignant brain tumors, currently comprising four distinct molecular subgroups: wingless [WNT],…”
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Abstract 982: A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Introduction: Renal cell carcinoma, particularly the clear cell histological subtype (ccRCC), is the most common kidney cancer in adults, accounting…”
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Abstract 631: Single-cell analysis of immune and stroma cell remodeling in renal cell carcinoma primary tumors and bone metastatic lesions
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract Background: Renal cell carcinoma (RCC) is the most common renal tumor in adults, and among these clear cell RCC (ccRCC) is most common subtype and…”
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