Search Results - "Tse, Janson"

Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells by Chueh, Anderly C, Tse, Janson W T, Tögel, Lars, Mariadason, John M

“…Class I and II histone deacetylase inhibitors (HDACis) are approved for the treatment of cutaneous T-cell lymphoma and are undergoing clinical trials as single…”
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ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types by Chüeh, Anderly C., Tse, Janson W.T., Dickinson, Michael, Ioannidis, Paul, Jenkins, Laura, Togel, Lars, Tan, BeeShin, Luk, Ian, Davalos-Salas, Mercedes, Nightingale, Rebecca, Thompson, Matthew R., Williams, Bryan R.G., Lessene, Guillaume, Lee, Erinna F., Fairlie, Walter D., Dhillon, Amardeep S., Mariadason, John M.

“…Abstract Purpose: Histone deacetylase inhibitors (HDACi) are epigenome-targeting small molecules approved for the treatment of cutaneous T-cell lymphoma and…”
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Aberrant DNA Methylation in Colorectal Cancer: What Should We Target? by Tse, Janson W T, Jenkins, Laura J, Chionh, Fiona, Mariadason, John M

“…Colorectal cancers (CRCs) are characterized by global hypomethylation and promoter-specific DNA methylation. A subset of CRCs with extensive and co-ordinate…”
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Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression by Luk, Ian Y., Jenkins, Laura J., Schoffer, Kael L., Ng, Irvin, Tse, Janson W. T., Mouradov, Dmitri, Kaczmarczyk, Stanislaw, Nightingale, Rebecca, Burrows, Allan D., Anderson, Robin L., Arango, Diego, Dopeso, Higinio, Croft, Larry, Richardson, Mark F., Sieber, Oliver M., Liao, Yang, Mooi, Jennifer K., Vukelic, Natalia, Reehorst, Camilla M., Afshar-Sterle, Shoukat, Whitehall, Vicki L. J., Fennell, Lochlan, Abud, Helen E., Tebbutt, Niall C., Phillips, Wayne A., Williams, David S., Shi, Wei, Mielke, Lisa A., Ernst, Matthias, Dhillon, Amardeep S., Clemons, Nicholas J., Mariadason, John M.

“…Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecular underpinnings of this trait and whether…”
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Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death by Jenkins, Laura J, Luk, Ian Y, Fairlie, W Douglas, Lee, Erinna F, Palmieri, Michelle, Schoffer, Kael L, Tan, Tao, Ng, Irvin, Vukelic, Natalia, Tran, Sharon, Tse, Janson W T, Nightingale, Rebecca, Alam, Zakia, Chionh, Fiona, Iatropoulos, George, Ernst, Matthias, Afshar-Sterle, Shoukat, Desai, Jayesh, Gibbs, Peter, Sieber, Oliver M, Dhillon, Amardeep S, Tebbutt, Niall C, Mariadason, John M

“…The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyperactivated in most colorectal cancers. A current limitation of inhibitors of this pathway is that they…”
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K‐Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines by Yeung, Yvonne, Lau, David K., Chionh, Fiona, Tran, Hoanh, Tse, Janson W. T., Weickhardt, Andrew J., Nikfarjam, Mehrdad, Scott, Andrew M., Tebbutt, Niall C., Mariadason, John M.

“…Advanced biliary tract cancer (BTC) has a poor prognosis and limited treatment options. The PI3K/Akt/mTOR signalling pathway is hyperactivated in a subset of…”
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Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells by Carli, Annalisa L. E., Afshar‐Sterle, Shoukat, Rai, Alin, Fang, Haoyun, O'Keefe, Ryan, Tse, Janson, Ferguson, Fleur M., Gray, Nathanael S., Ernst, Matthias, Greening, David W., Buchert, Michael

“…Doublecortin‐like kinase 1 (DCLK1) is a putative cancer stem cell marker, a promising diagnostic and prognostic maker for malignant tumors and a proposed…”
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DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression by Afshar-Sterle, Shoukat, Carli, Annalisa L E, O'Keefe, Ryan, Tse, Janson, Fischer, Stefanie, Azimpour, Alexander I, Baloyan, David, Elias, Lena, Thilakasiri, Pathum, Patel, Onisha, Ferguson, Fleur M, Eissmann, Moritz F, Chand, Ashwini L, Gray, Nathanael S, Busuttil, Rita, Boussioutas, Alex, Lucet, Isabelle S, Ernst, Matthias, Buchert, Michael

“…Doublecortin-like kinase 1 (DCLK1) is a proposed driver of gastric cancer (GC) that phosphorylates serine and threonine residues. Here, we showed that the…”
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Onco-miR-21 Promotes Stat3-Dependent Gastric Cancer Progression by Tse, Janson, Pierce, Thomas, Carli, Annalisa L E, Alorro, Mariah G, Thiem, Stefan, Marcusson, Eric G, Ernst, Matthias, Buchert, Michael

“…MicroRNA-21 (miR-21) is a small, non-coding RNA overexpressed in gastric cancer and many other solid malignancies, where it exhibits both pro-and…”
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Correction: ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors Across Tumor Types by Chüeh, Anderly C., Tse, Janson W.T., Dickinson, Michael, Ioannidis, Paul, Jenkins, Laura, Togel, Lars, Tan, BeeShin, Luk, Ian, Davalos-Salas, Mercedes, Nightingale, Rebecca, Thompson, Matthew R., Williams, Bryan R.G., Lessene, Guillaume, Lee, Erinna F., Fairlie, Walter D., Dhillon, Amardeep S., Mariadason, John M.

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A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors by Tse, Janson, O’Keefe, Ryan, Rigopolous, Angela, Carli, Annalisa L. E, Waaler, Jo, Krauss, Stefan, Ernst, Matthias, Buchert, Michael

“…Specific signalling thresholds of the WNT/β-catenin pathway affect embryogenesis and tissue homeostasis in the adult, with mutations in this pathway frequently…”
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Abstract 3089: Combining MEK and HDAC inhibitors as a therapeutic strategy to promote differentiation of colorectal cancer by Jenkins, Laura J., Luk, Ian Y., Tse, Janson W., Mooi, Jennifer, Dhillon, Amardeep S., Mariadason, John M.

“…Abstract The five-year survival rate for patients with metastatic colorectal cancer is less than 15%, necessitating an urgent need to develop novel therapeutic…”
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Abstract 2339: Transcriptional basis for loss of cellular differentiation in colon cancer by Luk, Ian Y., Tran, Hoanh, Tse, Janson W., Chueh, Anderly C., Chionh, Fiona, Clemons, Nicholas J., Mariadason, John M.

“…Abstract Background: Colon cancer is a leading cause of cancer related death. Colon cancer arises due to uncontrolled cell proliferation, failure of cells to…”
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Abstract 4728: Histone deacetylase inhibitors induce apoptosis in multiple tumor types through induction of ATF3 by Chueh, Anderly C., Tse, Janson, Ioannidis, Paul, Tögel, Lars, Tan, Bee S., Davlos-Salas, Mercedes, Nightingale, Rebecca, Thompson, Matthew R., Williams, Bryan, Dickinson, Michael, Dhillon, Amardeep S., Mariadason, John M.

“…Abstract Histone deacetylase inhibitors (HDACi) are approved for the treatment of cutaneous T-Cell lymphoma (CTCL) and Multiple Myeloma. In colon cancer cells…”
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ATF3 Repression of BCL-X L Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types by Chüeh, Anderly C, Tse, Janson W T, Dickinson, Michael, Ioannidis, Paul, Jenkins, Laura, Togel, Lars, Tan, BeeShin, Luk, Ian, Davalos-Salas, Mercedes, Nightingale, Rebecca, Thompson, Matthew R, Williams, Bryan R G, Lessene, Guillaume, Lee, Erinna F, Fairlie, Walter D, Dhillon, Amardeep S, Mariadason, John M

“…Histone deacetylase inhibitors (HDACi) are epigenome-targeting small molecules approved for the treatment of cutaneous T-cell lymphoma and multiple myeloma…”
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Abstract 5112: Histone deacetylase and proteasome inhibitors synergistically induce apoptosis in colon cancer, multiple myeloma and CTCL cells through induction of the immediate early genes ATF3 and JUN by Tse, Janson W., Chueh, Anderly C., Luk, Ian Y., Chionh, Fiona, Yeung, Yvonne, Corner, Georgia A., Ng, Dominic C., Tran, Hoanh, Dhillon, Amardeep S., Mariadason, John M.

“…Abstract Background/Aim: Histone deacetylase inhibitors (HDACi) are approved for the treatment of cutaneous T-cell lymphoma. We have previously demonstrated…”
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Abstract B014: Genotype-tailored ERK/MAPK pathway and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death by Jenkins, Laura J., Luk, Ian Y., Fairlie, Walter D., Lee, Erinna F., Palmieri, Michelle, Schoffer, Kael L., Tan, Tao, Ng, Irvin, Vukelic, Natalia, Tran, Sharon, Tse, Janson, Nightingale, Rebecca, Alam, Zakia, Chionh, Fiona, Iatropoulos, George, Ernst, Matthias, Afshar-Sterle, Shoukat, Desai, Jayesh, Gibbs, Peter, Sieber, Oliver M., Dhillon, Amardeep S., Tebbutt, Niall C., Mariadason, John M.

“…Abstract The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyper-activated in most colorectal cancers (CRCs). A current limitation of inhibitors of this…”
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