Search Results - "Tse, Edwin G."

The past, present and future of anti-malarial medicines by Tse, Edwin G, Korsik, Marat, Todd, Matthew H

“…Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide. Notably, the use of insecticide-treated…”
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Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities by Munawar, Saba, Windley, Monique J, Tse, Edwin G, Todd, Matthew H, Hill, Adam P, Vandenberg, Jamie I, Jabeen, Ishrat

“…The hERG (human ether-a-go-go-related gene) encoded potassium ion (K ) channel plays a major role in cardiac repolarization. Drug-induced blockade of hERG has…”
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Open science approaches to COVID-19 [version 1; peer review: 2 approved] by Tse, Edwin G, Klug, Dana M, Todd, Matthew H

“…In only a matter of months, the coronavirus disease of 2019 (COVID-19) has spread around the world. The global impact of the disease has caused significant and…”
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Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials by Tse, Edwin G, Houston, Sevan D, Williams, Craig M, Savage, G. Paul, Rendina, Louis M, Hallyburton, Irene, Anderson, Mark, Sharma, Raman, Walker, Gregory S, Obach, R. Scott, Todd, Matthew H

“…The replacement of one chemical motif with another that is broadly similar is a common method in medicinal chemistry to modulate the physical and biological…”
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tele-Substitution Reactions in the Synthesis of a Promising Class of 1,2,4-Triazolo[4,3‑a]pyrazine-Based Antimalarials by Korsik, Marat, Tse, Edwin G, Smith, David G, Lewis, William, Rutledge, Peter J, Todd, Matthew H

“…We have discovered and studied a tele-substitution reaction in a biologically important heterocyclic ring system. Conditions that favor the tele-substitution…”
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Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach by Merten, Eric M, Sears, John D, Leisner, Tina M, Hardy, P Brian, Ghoshal, Anirban, Hossain, Mohammad Anwar, Asressu, Kesatebrhan Haile, Brown, Peter J, Tse, Edwin G, Stashko, Michael A, Li, Kelin, Norris-Drouin, Jacqueline L, Herring, Laura E, Mordant, Angie L, Webb, Thomas S, Mills, Christine A, Barker, Natalie K, Streblow, Zachary J, Perveen, Sumera, Arrowsmith, Cheryl H, Couñago, Rafael Miguez, Arnold, Jamie J, Cameron, Craig E, Streblow, Daniel N, Moorman, Nathaniel J, Heise, Mark T, Willson, Timothy M, Popov, Konstantin I, Pearce, Kenneth H

“…Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has been responsible for numerous large-scale outbreaks in the last twenty years. Currently,…”
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An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials by Tse, Edwin G, Aithani, Laksh, Anderson, Mark, Cardoso-Silva, Jonathan, Cincilla, Giovanni, Conduit, Gareth J, Galushka, Mykola, Guan, Davy, Hallyburton, Irene, Irwin, Benedict W. J, Kirk, Kiaran, Lehane, Adele M, Lindblom, Julia C. R, Lui, Raymond, Matthews, Slade, McCulloch, James, Motion, Alice, Ng, Ho Leung, Öeren, Mario, Robertson, Murray N, Spadavecchio, Vito, Tatsis, Vasileios A, van Hoorn, Willem P, Wade, Alexander D, Whitehead, Thomas M, Willis, Paul, Todd, Matthew H

“…The Open Source Malaria (OSM) consortium is developing compounds that kill the human malaria parasite, Plasmodium falciparum, by targeting PfATP4, an essential…”
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Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus by Klug, Dana M, Tse, Edwin G, Silva, Daniel G, Cao, Yafeng, Charman, Susan A, Chauhan, Jyoti, Crighton, Elly, Dichiara, Maria, Drake, Chris, Drewry, David, da Silva Emery, Flavio, Ferrins, Lori, Graves, Lee, Hopkins, Emily, Kresina, Thomas A C, Lorente-Macías, Álvaro, Perry, Benjamin, Phipps, Richard, Quiroga, Bruno, Quotadamo, Antonio, Sabatino, Giada N, Sama, Anthony, Schätzlein, Andreas, Simpson, Quillon J, Steele, Jonathan, Shanu-Wilson, Julia, Sjö, Peter, Stapleton, Paul, Swain, Christopher J, Vaideanu, Alexandra, Xie, Huanxu, Zuercher, William, Todd, Matthew H

“…Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it…”
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Structure–Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis by Dichiara, Maria, Simpson, Quillon J., Quotadamo, Antonio, Jalani, Hitesh B., Huang, Anson X., Millard, Caroline C., Klug, Dana M., Tse, Edwin G., Todd, Matthew H., Silva, Daniel Gedder, da Silva Emery, Flavio, Carlson, J. Eric, Zheng, Shao-Liang, Vleminckx, Margot, Matheeussen, An, Caljon, Guy, Pollastri, Michael P., Sjö, Peter, Perry, Benjamin, Ferrins, Lori

“…Leishmaniasis is a collection of diseases caused by more than 20 Leishmania parasite species that manifest as either visceral, cutaneous, or mucocutaneous…”
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