Parenteral monofluorophosphate (MFP) is a more potent inducer of enamel fluorotic defects in neonatal hamster molars than sodium fluoride

[Abstract] Supra-optimal intake of sodium fluoride (NaF) during early childhood results in formation of irreversible enamel defects. Monofluorophosphate (MFP) was considered as less toxic than NaF but equally cariostatic. We compared the potency of MFP and NaF to induce pre-eruptive sub-ameloblastic...

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Bibliographic Details
Published in:	Odontology Vol. 102; no. 2; pp. 147 - 153
Main Authors:	Lyaruu, Donacian M., Schoonderwoerd, Mark, Tio, Dane, Tse, Chukan, Bervoets, Theodore J., DenBesten, Pamela, Bronckers, Antonius L. J. J.
Format:	Journal Article
Language:	English
Published:	Tokyo The Society of the Nippon Dental University 01-07-2014 Springer Japan Springer Nature B.V
Subjects:	Alkaline Phosphatase - metabolism Animals Animals, Newborn Cricetinae Dental Enamel - drug effects Dental Enamel - enzymology Dental Enamel - pathology Dentistry Enamel Enzymes Fluorides Fluorides - administration & dosage Fluorides - pharmacology Fluorosis, Dental - etiology Fluorosis, Dental - pathology Infusions, Parenteral Medicine Odontology Oral and Maxillofacial Surgery Original Article Phosphates - administration & dosage Phosphates - pharmacology Sodium Fluoride - administration & dosage Sodium Fluoride - pharmacology Alkaline phosphatase NaF Fluoride Cysts MFP White spots Pits
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Summary:	[Abstract] Supra-optimal intake of sodium fluoride (NaF) during early childhood results in formation of irreversible enamel defects. Monofluorophosphate (MFP) was considered as less toxic than NaF but equally cariostatic. We compared the potency of MFP and NaF to induce pre-eruptive sub-ameloblastic cysts and post-eruptive white spots and pits in developing hamster enamel. Hamster pups were injected subcutaneously with either NaF or MFP in equimolar doses of either 9mg or 18mg F/kg body weight. At 9mg F/kg, MFP induced more but smaller sub-ameloblastic cysts with a collective cyst volume twice as large as that induced by NaF. Eight days after F injection, all F-injected groups had formed 4-6 white spots per molar, with an additional 2 pits per molar in the low MFP group. Twenty-eight days after injection, most white spots had turned into pits (5-6 per molar) and only the high MFP group still contained 2 white spots per molar. We conclude that parenterally applied MFP is more potent in inducing enamel defects than NaF. Most white spots formed turn into pits by functional use of the dentition. The higher potency of parenteral MFP may be associated with sustained elevated F levels in the enamel organ by enzymatic hydrolysis of MFP by alkaline phosphatase activity.
ISSN:	1618-1247 1618-1255
DOI:	10.1007/s10266-013-0119-0