Search Results - "Tschopp, Thomas B"

Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity by Zbinden, Katrin Groebke, Banner, David W., Hilpert, Kurt, Himber, Jacques, Lavé, Thierry, Riederer, Markus A., Stahl, Martin, Tschopp, Thomas B., Obst-Sander, Ulrike

“…The discovery of a highly potent and selective tissue factor/factor VIIa inhibitor is described. Upon oral administration of its double prodrug in the guinea…”
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Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors by Zbinden, Katrin Groebke, Obst-Sander, Ulrike, Hilpert, Kurt, Kühne, Holger, Banner, David W., Böhm, Hans-Joachim, Stahl, Martin, Ackermann, Jean, Alig, Leo, Weber, Lutz, Wessel, Hans Peter, Riederer, Markus A., Tschopp, Thomas B., Lavé, Thierry

“…We describe the structure-based design and synthesis of nanomolar, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the…”
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Can the calculation of ligand binding free energies be improved with continuum solvent electrostatics and an ideal‐gas entropy correction? by Schwarzl, Sonja M., Tschopp, Thomas B., Smith, Jeremy C., Fischer, Stefan

“…The prediction of a ligand binding constant requires generating three‐dimensional structures of the complex concerned and reliably scoring these structures…”
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Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors by Groebke Zbinden, Katrin, Banner, David W., Ackermann, Jean, D’Arcy, Allan, Kirchhofer, Daniel, Ji, Yu-Hua, Tschopp, Thomas B., Wallbaum, Sabine, Weber, Lutz

“…Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting…”
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Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors by Hilpert, Kurt, Ackermann, Jean, Banner, David W., Gast, Alain, Gubernator, Klaus, Hadvary, Paul, Labler, Ludvik, Mueller, Klaus, Schmid, Gerard

“…Thrombin, a serine protease, plays a central role in the initiation and propagation of thrombotic events. An extensive search for new thrombin inhibitors was…”
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Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function by Himber, J, Kirchhofer, D, Riederer, M, Tschopp, T B, Steiner, B, Roux, S P

“…Inhibition of the tissue factor/factor VIIa (TF/F.VIIa) complex attenuates thrombosis in different animal models of arterial thrombosis. However, it remains…”
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Active Site-Blocked Factors VIIa and IXa Differentially Inhibit Fibrin Formation in a Human Ex Vivo Thrombosis Model by Kirchhofer, Daniel, Tschopp, Thomas B, Baumgartner, Hans R

“…The role of tissue factor/factor VIIa (FVIIa) and factor VIIIa/factor IXa (FVIIIa/FIXa) complexes in thrombus formation was examined in a human ex vivo blood…”
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Activated clotting time as a appropriate test to compare heparin and direct thrombin inhibitors such as hirudin or Ro 46-6240 in experimental arterial thrombosis by CARTEAUX, J. P, GAST, A, TSCHOPP, T. B, ROUX, S

“…Specific thrombin inhibitors are considered to be more potent antithrombotics than heparin. However, the relation between the systemic anticoagulation…”
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Impaired interaction (adhesion-aggregation) of platelets with the subendothelium in storage-pool disease and after aspirin ingestion. A comparison with von Willebrand's disease by Weiss, H J, Tschopp, T B, Baumgartner, H R

“…Possible defects in the interaction of platelets with the subendothelial surface were evaluated in six patients with storeage-pool disease, nine patients with…”
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Endothelial cells stimulated with tumor necrosis factor-alpha express varying amounts of tissue factor resulting in inhomogenous fibrin deposition in a native blood flow system. Effects of thrombin inhibitors by Kirchhofer, D, Tschopp, T B, Hadváry, P, Baumgartner, H R

“…TNF-alpha induces changes in endothelial cell functions, such as upregulation of tissue factor, resulting in endothelial procoagulant activity which may play a…”
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Role of Collagen-Adherent Platelets in Mediating Fibrin Formation in Flowing Whole Blood by Kirchhofer, Daniel, Tschopp, Thomas B., Steiner, Beat, Baumgartner, Hans R.

“…Activated platelets provide assembly sites for coagulation enzyme complexes and in this way can mediate coagulation during hemostasis and thrombosis. In this…”
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Activated clotting time as an appropriate test to compare heparin and direct thrombin inhibitor such as hirudin or Ro 46-6240 in experimental arterial thrombosis by Carteaux, Jean Pierre, Gast, Alain, Tschopp, Thomas B, Roux, Sebastien

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Relationship between tissue factor expression and deposition of fibrin, platelets, and leukocytes on cultured endothelial cells under venous blood flow conditions by KIRCHHOFER, D, SAKARIASSEN, K. S, CLOZEL, M, TSCHOPP, T. B, HADVARY, P, NEMERSON, Y, BAUMGARTNER, H. R

“…Endothelial cell-mediated coagulation and leukocyte adhesion are processes that might be connected by the generation of thrombin. To examine the interaction of…”
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The heparin-like antiproliferative activity of sulfated tetrasaccharides is sensitive to structural variation by Wessel, Hans Peter, Vieira, Eric, Trumtel, Michel, Tschopp, Thomas B., Iberg, Niggi

“…The sulfated tetrasaccharide β-maltosyl-(1→4)-α,α-trehalose 2 with high antiproliferative activity on smooth muscle cells was modified in the maltosyl moiety…”
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Heparin, carboxyl-reduced sulfated heparin, and Trestatin A sulfate. Antiproliferative and anticoagulant activities by Wessel, H P, Hosang, M, Tschopp, T B, Weimann, B J

“…Human smooth muscle cells were used to investigate the antiproliferative activities of sulfated carbohydrates. The antiproliferative potencies of coarse…”
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The Development of Potent and Highly Selective Thrombin Inhibitors by Hilpert, Kurt, Ackermann, Jean, Banner, David W., Gast, Alain, Gubernator, Klaus, Schmid, Gérard, Tschopp, Thomas B., van de Waterbeemd, Han

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Platelet adhesion, release and aggregation in flowing blood: effects of surface properties and platelet function by Baumgartner, H R, Muggli, R, Tschopp, T B, Turitto, V T

“…Platelet adhesion to natural and artificial surfaces and adhesion-induced aggregation were investigated in vitro using an annular perfusion chamber. The…”
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Decreased adhesion of giant (Bernard-Soulier) platelets to subendothelium. Further implications on the role of the von Willebrand factor in hemostasis by Weiss, H J, Tschopp, T B, Baumgartner, H R, Sussman, I I, Johnson, M M, Egan, J J

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Hereditary Defect in Platelet Function in Rats by Tschopp, Thomas B., Zucker, Marjorie B.

“…Hemostatic parameters of fawn- hooded (FH) rats with an inherited hemorrhagic diathesis were compared with those of normal rats. Prothrombin time, partial…”
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Platelet interaction with collagen fibrils in flowing blood. II. Impaired adhesion-aggregation in bleeding disorders. A comparison with subendothelium by Baumgartner, H R, Tschopp, T B, Weiss, H J

“…Anticoagulated whole blood from patients and control subjects was circulated through an annular perfusion chamber in which the fibrillar collagen of alpha…”
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