Search Results - "Tschoep, H."

Crop wild relative populations of Beta vulgaris allow direct mapping of agronomically important genes by Capistrano-Gossmann, Gina G., Ries, D., Holtgräwe, D., Minoche, A., Kraft, T., Frerichmann, S.L.M., Rosleff Soerensen, T., Dohm, J. C., González, I., Schilhabel, M., Varrelmann, M., Tschoep, H., Uphoff, H., Schütze, K., Borchardt, D., Toerjek, O., Mechelke, W., Lein, J. C., Schechert, A. W., Frese, L., Himmelbauer, H., Weisshaar, B., Kopisch-Obuch, F. J.

“…Rapid identification of agronomically important genes is of pivotal interest for crop breeding. One source of such genes are crop wild relative (CWR)…”
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Molecular classification of the placebo effect in nausea by Meissner, Karin, Lutter, Dominik, von Toerne, Christine, Haile, Anja, Woods, Stephen C, Hoffmann, Verena, Ohmayer, Uli, Hauck, Stefanie M, Tschoep, Matthias H

“…In this proof-of-concept study, we tested whether placebo effects can be monitored and predicted by plasma proteins. In a randomized controlled design, 90…”
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Central correlates of placebo effects in nausea differ between men and women by Haile, Anja, Watts, Mallissa, Aichner, Simone, Stahlberg, Franziska, Hoffmann, Verena, Tschoep, Matthias H., Meissner, Karin

“…Introduction Despite growing evidence validating placebo effects in nausea, little is known about the underlying cortical mechanisms in women and men…”
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Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities by Kohli, Rohit, Kirby, Michelle, Setchell, Kenneth D R, Jha, Pinky, Klustaitis, Kori, Woollett, Laura A, Pfluger, Paul T, Balistreri, William F, Tso, Patrick, Jandacek, Ronald J, Woods, Stephen C, Heubi, James E, Tschoep, Matthias H, D'Alessio, David A, Shroyer, Noah F, Seeley, Randy J

“…Surgical interposition of distal ileum into the proximal jejunum is a bariatric procedure that improves the metabolic syndrome. Changes in intestinal and…”
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Towards the genetic architecture of seed lipid biosynthesis and accumulation in Arabidopsis thaliana by O'Neill, C M, Morgan, C, Hattori, C, Brennan, M, Rosas, U, Tschoep, H, Deng, P X, Baker, D, Wells, R, Bancroft, I

“…We report the quantitative genetic analysis of seed oil quality and quantity in six Arabidopsis thaliana recombinant inbred populations, in which the parent…”
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Ghrelin in the regulation of body weight and metabolism by Castañeda, T.R, Tong, J, Datta, R, Culler, M, Tschöp, M.H

“…Abstract Ghrelin, a peptide hormone predominantly produced by the stomach, was isolated as the endogenous ligand for the growth hormone secretagogue receptor…”
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Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity by Horvath, Tamas L., Sarman, Beatrix, García-Cáceres, Cristina, Enriori, Pablo J., Sotonyi, Peter, Shanabrough, Marya, Borok, Erzsebet, Argente, Jesus, Chowen, Julie A., Perez-Tilve, Diego, Pfluger, Paul T., Brönneke, Hella S., Levin, Barry E., Diano, Sabrina, Cowley, Michael A., Tschöp, Matthias H., Friedman, Jeffrey M.

“…The neuronal circuits involved in the regulation of feeding behavior and energy expenditure are soft-wired, reflecting the relative activity of the…”
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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents by DiMarchi, Richard, Day, Jonathan W, Ottaway, Nickki, Patterson, James T, Gelfanov, Vasily, Smiley, David, Gidda, Jas, Findeisen, Hannes, Bruemmer, Dennis, Drucker, Daniel J, Chaudhary, Nilika, Holland, Jenna, Hembree, Jazzminn, Abplanalp, William, Grant, Erin, Ruehl, Jennifer, Wilson, Hilary, Kirchner, Henriette, Lockie, Sarah Haas, Hofmann, Susanna, Woods, Stephen C, Nogueiras, Ruben, Pfluger, Paul T, Perez-Tilve, Diego, Tschöp, Matthias H

“…We report the efficacy of a new peptide with agonism at the glucagon and GLP-1 receptors that has potent, sustained satiation-inducing and lipolytic effects…”
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GOAT links dietary lipids with the endocrine control of energy balance by Tschöp, Matthias H, Kirchner, Henriette, Gutierrez, Jesus A, Solenberg, Patricia J, Pfluger, Paul T, Czyzyk, Traci A, Willency, Jill A, Schürmann, Annette, Joost, Hans-Georg, Jandacek, Ronald J, Hale, John E, Heiman, Mark L

“…Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy…”
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Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor by Barnett, Brad P., Hwang, Yousang, Taylor, Martin S., Kirchner, Henriette, Pfluger, Paul T., Bernard, Vincent, Lin, Yu-yi, Bowers, Erin M., Mukherjee, Chandrani, Song, Woo-Jin, Longo, Patti A., Leahy, Daniel J., Hussain, Mehboob A., Tschöp, Matthias H., Boeke, Jef D., Cole, Philip A.

“…Ghrelin is a gastric peptide hormone that stimulates weight gain in vertebrates. The biological activities of ghrelin require octanoylation of the peptide on…”
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Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content by Disse, Emmanuel, Bussier, Anne-Lise, Veyrat-Durebex, Christelle, Deblon, Nicolas, Pfluger, Paul T, Tschöp, Matthias H, Laville, Martine, Rohner-Jeanrenaud, Françoise

“…Abstract Aims Ghrelin is one of the most potent orexigens known to date. While the prevailing view is that ghrelin participates in the homeostatic control of…”
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Ghrelin in eating disorders by Yi, Chun-Xia, Heppner, Kristy, Tschöp, Matthias H.

“…Ghrelin is the only known circulating hormone that acts on peripheral and central targets to increase food intake and promote adiposity. The present review…”
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Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism by Lim, Chung Thong, Kola, Blerina, Feltrin, Daniel, Perez-Tilve, Diego, Tschöp, Matthias H., Grossman, Ashley B., Korbonits, Márta

“…► Ghrelin requires GHS-R1a for its effect on hypothalamic, liver and adipose tissue AMPK activity. ► An intact ghrelin signalling pathway is required for the…”
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Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants by Shin, Yu-Kyong, Martin, Bronwen, Kim, Wook, White, Caitlin M, Ji, Sunggoan, Sun, Yuxiang, Smith, Roy G, Sévigny, Jean, Tschöp, Matthias H, Maudsley, Stuart, Egan, Josephine M

“…The gustatory system plays a critical role in determining food preferences, food intake and energy balance. The exact mechanisms that fine tune taste…”
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Melanocortin signaling in the CNS directly regulates circulating cholesterol by Perez-Tilve, Diego, Hofmann, Susanna M, Basford, Joshua, Nogueiras, Ruben, Pfluger, Paul T, Patterson, James T, Grant, Erin, Wilson-Perez, Hilary E, Granholm, Norman A, Arnold, Myrtha, Trevaskis, James L, Butler, Andrew A, Davidson, William S, Woods, Stephen C, Benoit, Stephen C, Sleeman, Mark W, DiMarchi, Richard D, Hui, David Y, Tschöp, Matthias H

“…This study finds that inhibition of the hypothalamic melanocortin receptors increases the level of high-density lipoprotein HDL-C, a form of cholesterol,…”
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The endocannabinoid system: Role in glucose and energy metabolism by Nogueiras, Ruben, Diaz-Arteaga, Adenis, Lockie, Sarah H., Velásquez, Douglas A., Tschop, Johannes, López, Miguel, Cadwell, Charles C., Diéguez, Carlos, Tschöp, Matthias H.

“…The endocannabinoid system (ECS) has emerged as one of the most relevant regulators of energy balance. The ECS acts through two cannabinoid receptors: types 1…”
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Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase ( GOAT ) is associated with anorexia nervosa by Müller, Timo D, Tschöp, Matthias H, Jarick, Ivonne, Ehrlich, Stefan, Scherag, Susann, Herpertz-Dahlmann, Beate, Zipfel, Stefan, Herzog, Wolfgang, de Zwaan, Martina, Burghardt, Roland, Fleischhaker, Christian, Klampfl, Karin, Wewetzer, Christoph, Herpertz, Stephan, Zeeck, Almut, Tagay, Sefik, Burgmer, Markus, Pfluger, Paul T, Scherag, André, Hebebrand, Johannes, Hinney, Anke

“…Abstract The gastrointestinal peptide hormone ghrelin promotes food intake and increases body weight and adiposity through activation of the growth hormone…”
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CNS Opioid Signaling Separates Cannabinoid Receptor 1-Mediated Effects on Body Weight and Mood-Related Behavior in Mice by Lockie, Sarah Haas, Czyzyk, Traci A, Chaudhary, Nilika, Perez-Tilve, Diego, Woods, Stephen C, Oldfield, Brian J, Statnick, Michael A, Tschöp, Matthias H

“…Existing monotherapies for the treatment of obesity provide only modest weight loss and/or have adverse side effects, and this is also the case with the…”
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Systemic ghrelin and reward: Effect of cholinergic blockade by Disse, E, Bussier, A.L, Deblon, N, Pfluger, P.T, Tschöp, M.H, Laville, M, Rohner-Jeanrenaud, F

“…Abstract Aims Ghrelin is one of the most potent orexigens known to date. Recent data suggested that ghrelin is involved in reward-mediated processes such as…”
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Bsx, a Novel Hypothalamic Factor Linking Feeding with Locomotor Activity, Is Regulated by Energy Availability by Nogueiras, Ruben, López, Miguel, Lage, Ricardo, Perez-Tilve, Diego, Pfluger, Paul, Mendieta-Zerón, Hugo, Sakkou, Maria, Wiedmer, Petra, Benoit, Stephen C, Datta, Rakesh, Dong, Jesse Z, Culler, Michael, Sleeman, Mark, Vidal-Puig, Antonio, Horvath, Tamas, Treier, Mathias, Diéguez, Carlos, Tschöp, Matthias H

“…We recently reported that the hypothalamic homeobox domain transcription factor Bsx plays an essential role in the central nervous system control of…”
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