Search Results - "Tschida, Barbara"

Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis by Riordan, Jesse D, Keng, Vincent W, Tschida, Barbara R, Scheetz, Todd E, Bell, Jason B, Podetz-Pedersen, Kelly M, Moser, Catherine D, Copeland, Neal G, Jenkins, Nancy A, Roberts, Lewis R, Largaespada, David A, Dupuy, Adam J

“…We previously utilized a Sleeping Beauty (SB) transposon mutagenesis screen to discover novel drivers of HCC. This approach identified recurrent mutations…”
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Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice by Riordan, Jesse D., Feddersen, Charlotte R., Tschida, Barbara R., Beckmann, Pauline J., Keng, Vincent W., Linden, Michael A., Amin, Khalid, Stipp, Christopher S., Largaespada, David A., Dupuy, Adam J.

“…Most hepatocellular carcinomas (HCCs) develop in a chronically injured liver, yet the extent to which this microenvironment promotes neoplastic transformation…”
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Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation by Wu, Jianqiang, Keng, Vincent W., Patmore, Deanna M., Kendall, Jed J., Patel, Ami V., Jousma, Edwin, Jessen, Walter J., Choi, Kwangmin, Tschida, Barbara R., Silverstein, Kevin A.T., Fan, Danhua, Schwartz, Eric B., Fuchs, James R., Zou, Yuanshu, Kim, Mi-Ok, Dombi, Eva, Levy, David E., Huang, Gang, Cancelas, Jose A., Stemmer-Rachamimov, Anat O., Spinner, Robert J., Largaespada, David A., Ratner, Nancy

“…To identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse…”
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Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors by Tschida, Barbara R, Temiz, Nuri A, Kuka, Timothy P, Lee, Lindsey A, Riordan, Jesse D, Tierrablanca, Carlos A, Hullsiek, Robert, Wagner, Sandra, Hudson, Wendy A, Linden, Michael A, Amin, Khalid, Beckmann, Pauline J, Heuer, Rachel A, Sarver, Aaron L, Yang, Ju Dong, Roberts, Lewis R, Nadeau, Joseph H, Dupuy, Adam J, Keng, Vincent W, Largaespada, David A

“…Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated…”
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HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism by Chiu, Amy P, Tschida, Barbara R, Sham, Tung-Ting, Lo, Lilian H, Moriarity, Branden S, Li, Xiao-Xiao, Lo, Regina C, Hinton, David E, Rowlands, Dewi K, Chan, Chi-On, Mok, Daniel K W, Largaespada, David A, Warner, Nadia, Keng, Vincent W

“…Chronic hepatitis B viral (HBV) infection remains a high underlying cause for hepatocellular carcinoma (HCC) worldwide, while the genetic mechanisms behind…”
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PTEN and NF1 Inactivation in Schwann Cells Produces a Severe Phenotype in the Peripheral Nervous System That Promotes the Development and Malignant Progression of Peripheral Nerve Sheath Tumors by KENG, Vincent W, RAHRMANN, Eric P, WATSON, Adrienne L, TSCHIDA, Barbara R, MOERTEL, Christopher L, JESSEN, Walter J, RIZVI, Tilat A, COLLINS, Margaret H, RATNER, Nancy, LARGAESPADA, David A

“…The genetic evolution from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis type 1 (NF1) syndrome remains unclear. Schwann cells…”
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Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors by Beckmann, Pauline J, Larson, Jon D, Larsson, Alex T, Ostergaard, Jason P, Wagner, Sandra, Rahrmann, Eric P, Shamsan, Ghaidan A, Otto, George M, Williams, Rory L, Wang, Jun, Lee, Catherine, Tschida, Barbara R, Das, Paramita, Dubuc, Adrian M, Moriarity, Branden S, Picard, Daniel, Wu, Xiaochong, Rodriguez, Fausto J, Rosemarie, Quincy, Krebs, Ryan D, Molan, Amy M, Demer, Addison M, Frees, Michelle M, Rizzardi, Anthony E, Schmechel, Stephen C, Eberhart, Charles G, Jenkins, Robert B, Wechsler-Reya, Robert J, Odde, David J, Huang, Annie, Taylor, Michael D, Sarver, Aaron L, Largaespada, David A

“…Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited…”
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Modeling hepatitis B virus X–induced hepatocellular carcinoma in mice with the sleeping beauty transposon system by Keng, Vincent W., Tschida, Barbara R., Bell, Jason B., Largaespada, David A.

“…The mechanisms associated with hepatitis B virus (HBV)–induced hepatocellular carcinoma (HCC) remain elusive, and there are currently no well‐established…”
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Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies by Tschida, Barbara R., Largaespada, David A., Keng, Vincent W.

“…•Sleeping Beauty (SB) transposon system is a useful genetic tool for cancer gene discovery.•SB transposon system used to model many human cancers.•Both forward…”
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ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis by To, Jeffrey C., Chiu, Amy P., Tschida, Barbara R., Lo, Lilian H., Chiu, Cynthia H., Li, Xiao-Xiao, Kuka, Timothy P., Linden, Michael A., Amin, Khalid, Chan, Wing-Cheung, Bell, Jason B., Moriarity, Branden S., Largaespada, David A., Keng, Vincent W.

“…Zinc finger and BTB domain containing 20 (ZBTB20) has been implicated as a potential oncogene in liver cancer. However, knockout studies have shown it to be a…”
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Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma by Chiu, Amy P, Tschida, Barbara R, Lo, Lilian H, Moriarity, Branden S, Rowlands, Dewi K, Largaespada, David A, Keng, Vincent W

“…The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The…”
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Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR by Keng, Vincent W., Sia, Daniela, Sarver, Aaron L., Tschida, Barbara R., Fan, Danhua, Alsinet, Clara, Solé, Manel, Lee, Wai L., Kuka, Timothy P., Moriarity, Branden S., Villanueva, Augusto, Dupuy, Adam J., Riordan, Jesse D., Bell, Jason B., T.Silverstein, Kevin A., Llovet, Josep M., Largaespada, David A.

“…Hepatocellular carcinoma (HCC) is one of the deadliest solid cancers and is the third leading cause of cancer‐related death. There is a universal estimated…”
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Abstract 63: A transposon-based forward genetic screen for steatosis-associated liver cancer drivers by Tschida, Barbara R., Temiz, N. Alpay, Yang, Ju D., Keng, Vincent W., Largaespada, David A.

“…Abstract Hepatocellular carcinoma (HCC), or liver cancer, is the second leading cause of death from cancer worldwide (Ferlay et al, Lyon, France: International…”
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R‐spondin 2 Drives Liver Tumor Development in a Yes‐Associated Protein‐Dependent Manner by Conboy, Caitlin B., Vélez‐Reyes, Germán L., Tschida, Barbara R., Hu, Hsiangyu, Kaufmann, Gabriel, Koes, Nicholas, Keller, Bryant, Alsinet, Clara, Cornellà, Helena, Pinyol, Roser, Abrahante, Juan E., Temiz, Nuri A., Linden, Michael A., Amin, Khalid, Kuka, Timothy P., Keng, Vincent W., Llovet, Josep M., Starr, Timothy K., Largaespada, David A.

“…Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death…”
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Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo by Osum, Sara H, Coutts, Alexander W, Duerre, Dylan J, Tschida, Barbara R, Kirstein, Mark N, Fisher, James, Bell, W Robert, Delpuech, Oona, Smith, Paul D, Widemann, Brigitte C, Moertel, Christopher L, Largaespada, David A, Watson, Adrienne L

“…Abstract Background The MEK1/2 inhibitor selumetinib was recently approved for neurofibromatosis type 1 (NF1)-associated plexiform neurofibromas, but outcomes…”
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Overexpression of HGF/MET axis along with p53 inhibition induces de novo glioma formation in mice by Qin, Yuan, Musket, Anna, Kou, Jianqun, Preiszner, Johanna, Tschida, Barbara R, Qin, Anna, Land, Craig A, Staal, Ben, Kang, Liang, Tanner, Kirk, Jiang, Yong, Schweitzer, John B, Largaespada, David A, Xie, Qian

“…Abstract Background Aberrant MET receptor tyrosine kinase (RTK) activation leads to invasive tumor growth in different types of cancer. Overexpression of MET…”
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Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST by Keng, Vincent W., Watson, Adrienne L., Rahrmann, Eric P., Li, Hua, Tschida, Barbara R., Moriarity, Branden S., Choi, Kwangmin, Rizvi, Tilat A., Collins, Margaret H., Wallace, Margaret R., Ratner, Nancy, Largaespada, David A.

“…The genetic mechanisms involved in the transformation from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis-type-1-…”
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TMOD-20. A SWINE MODEL OF GLIOBLASTOMA INDUCED BY SOMATIC GENE MODIFICATION by Tschida, Barbara, Duerre, Dylan, Taisto, Mandy, Watson, Adrienne

“…Abstract Glioblastoma (GBM) is the most common and malignant primary brain tumor. Novel therapeutic development for GBM is needed since the standard of care…”
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Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling by Zuckermann, Marc, Hovestadt, Volker, Knobbe-Thomsen, Christiane B., Zapatka, Marc, Northcott, Paul A., Schramm, Kathrin, Belic, Jelena, Jones, David T. W., Tschida, Barbara, Moriarity, Branden, Largaespada, David, Roussel, Martine F., Korshunov, Andrey, Reifenberger, Guido, Pfister, Stefan M., Lichter, Peter, Kawauchi, Daisuke, Gronych, Jan

“…In vivo functional investigation of oncogenes using somatic gene transfer has been successfully exploited to validate their role in tumorigenesis. For tumour…”
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MODL-15. BRINGING PRECISION MEDICINE TO GLIOBLASTOMA PATIENTS BY MODELING MOLECULAR TUMOR SUBTYPES IN IMMUNOCOMPETENT SWINE FOR THERAPEUTIC AND BIOMARKER DEVELOPMENT by Watson, Adrienne, Korpela, Derek, Koes, Nicholas, Taisto, Mandy, Corbiere, Stanislas, Tschida, Barbara

“…Abstract Glioblastoma (GBM) is an aggressive primary brain tumor with no effective cure. Standard of care treatment offers dismal prognoses for patients with a…”
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