Search Results - "Tsao, Emily"
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Treponema pallidum Disrupts VE-Cadherin Intercellular Junctions and Traverses Endothelial Barriers Using a Cholesterol-Dependent Mechanism
Published in Frontiers in microbiology (20-07-2021)“…Treponema pallidum subspecies pallidum , the causative agent of syphilis, traverses the vascular endothelium to gain access to underlying tissue sites. Herein,…”
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Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity
Published in Haematologica (Roma) (01-09-2023)“…Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapeutic regimens to fully eradicate disease initiating…”
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Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina
Published in Stem cell research & therapy (14-03-2024)“…The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors…”
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Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751
Published in mSphere (01-04-2020)“…subsp. is the causative agent of syphilis, a human-specific sexually transmitted infection that causes a multistage disease with diverse clinical…”
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Identifying Stress Granules As Determinants of Leukemia Stem Cell Maintenance and Stress Adaptation
Published in Blood (02-11-2023)“…The development of novel leukemic stem cell (LSC)-targeted therapeutics, which spare hematopoietic stem cells (HSC), is an urgent goal towards reducing the…”
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Aberrant Splicing of MBD1 Reshapes the Epigenome to Drive Convergent Myeloerythroid Defects in MDS
Published in Blood (02-11-2023)“…Splicing defects are a characteristic feature of myelodysplastic syndromes (MDS) and typically associate with specific recurrent splicing factor mutations…”
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3171 – IDENTIFYING STRESS GRANULES AS DETERMINANTS OF LEUKEMIA STEM CELL MAINTENANCE AND STRESS ADAPTATION
Published in Experimental hematology (01-08-2024)“…Development of novel leukemic stem cell (LSC)-targeted therapeutics is an urgent goal towards reducing the high, LSC-driven, relapse rates in acute myeloid…”
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In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
Published in Blood cancer discovery (01-05-2023)“…Acute myeloid leukemia (AML) is fueled by leukemic stem cells (LSC) whose determinants are challenging to discern from hematopoietic stem cells (HSC) or…”
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