Search Results - "Tsanov, Kaloyan M."

Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Pearson, Daniel S., Roels, Frederik, Spina, Catherine S., Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theißen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C., LaPier, Grace S., Osborne, Jihan K., Ross, Samantha J., Cesana, Marcella, Collins, James J., Berthold, Frank, Daley, George Q.

“…Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN . MYCN is itself a target of let-7 , a tumour suppressor family of microRNAs…”
Get full text

LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency by Tsanov, Kaloyan M., Pearson, Daniel S., Wu, Zhaoting, Han, Areum, Triboulet, Robinson, Seligson, Marc T., Powers, John T., Osborne, Jihan K., Kane, Susan, Gygi, Steven P., Gregory, Richard I., Daley, George Q.

“…Daley and colleagues report that MAPK signalling controls pluripotency in embryonic stem cells and during somatic cell reprogramming by enhancing the stability…”
Get full text

A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development by Cesana, Marcella, Guo, Michael H., Cacchiarelli, Davide, Wahlster, Lara, Barragan, Jessica, Doulatov, Sergei, Vo, Linda T., Salvatori, Beatrice, Trapnell, Cole, Clement, Kendell, Cahan, Patrick, Tsanov, Kaloyan M., Sousa, Patricia M., Tazon-Vega, Barbara, Bolondi, Adriano, Giorgi, Federico M., Califano, Andrea, Rinn, John L., Meissner, Alexander, Hirschhorn, Joel N., Daley, George Q.

“…While gene expression dynamics have been extensively cataloged during hematopoietic differentiation in the adult, less is known about transcriptome diversity…”
Get full text

Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism by Shyh-Chang, Ng, Zhu, Hao, Yvanka de Soysa, T., Shinoda, Gen, Seligson, Marc T., Tsanov, Kaloyan M., Nguyen, Liem, Asara, John M., Cantley, Lewis C., Daley, George Q.

“…Regeneration capacity declines with age, but why juvenile organisms show enhanced tissue repair remains unexplained. Lin28a, a highly conserved RNA-binding…”
Get full text

Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-Derived Cytokines by Schwörer, Simon, Cimino, Francesco V, Ros, Manon, Tsanov, Kaloyan M, Ng, Charles, Lowe, Scott W, Carmona-Fontaine, Carlos, Thompson, Craig B

“…Cancer-associated fibroblasts (CAF) are a major cell type in the stroma of solid tumors and can exert both tumor-promoting and tumor-restraining functions. CAF…”
Get full text

A gene–environment-induced epigenetic program initiates tumorigenesis by Alonso-Curbelo, Direna, Ho, Yu-Jui, Burdziak, Cassandra, Maag, Jesper L. V., Morris, John P., Chandwani, Rohit, Chen, Hsuan-An, Tsanov, Kaloyan M., Barriga, Francisco M., Luan, Wei, Tasdemir, Nilgun, Livshits, Geulah, Azizi, Elham, Chun, Jaeyoung, Wilkinson, John E., Mazutis, Linas, Leach, Steven D., Koche, Richard, Pe’er, Dana, Lowe, Scott W.

“…Tissue damage increases the risk of cancer through poorly understood mechanisms 1 . In mouse models of pancreatic cancer, pancreatitis associated with tissue…”
Get full text

Ordered and deterministic cancer genome evolution after p53 loss by Baslan, Timour, Morris, John P., Zhao, Zhen, Reyes, Jose, Ho, Yu-Jui, Tsanov, Kaloyan M., Bermeo, Jonathan, Tian, Sha, Zhang, Sean, Askan, Gokce, Yavas, Aslihan, Lecomte, Nicolas, Erakky, Amanda, Varghese, Anna M., Zhang, Amy, Kendall, Jude, Ghiban, Elena, Chorbadjiev, Lubomir, Wu, Jie, Dimitrova, Nevenka, Chadalavada, Kalyani, Nanjangud, Gouri J., Bandlamudi, Chaitanya, Gong, Yixiao, Donoghue, Mark T. A., Socci, Nicholas D., Krasnitz, Alex, Notta, Faiyaz, Leach, Steve D., Iacobuzio-Donahue, Christine A., Lowe, Scott W.

“…Although p53 inactivation promotes genomic instability 1 and presents a route to malignancy for more than half of all human cancers 2 , 3 , the patterns…”
Get full text

Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants by Sánchez-Rivera, Francisco J., Diaz, Bianca J., Kastenhuber, Edward R., Schmidt, Henri, Katti, Alyna, Kennedy, Margaret, Tem, Vincent, Ho, Yu-Jui, Leibold, Josef, Paffenholz, Stella V., Barriga, Francisco M., Chu, Kevan, Goswami, Sukanya, Wuest, Alexandra N., Simon, Janelle M., Tsanov, Kaloyan M., Chakravarty, Debyani, Zhang, Hongxin, Leslie, Christina S., Lowe, Scott W., Dow, Lukas E.

“…Base editing can be applied to characterize single nucleotide variants of unknown function, yet defining effective combinations of single guide RNAs (sgRNAs)…”
Get full text

LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy by Missios, Pavlos, da Rocha, Edroaldo Lummertz, Pearson, Daniel S, Philipp, Julia, Aleman, Maria M, Pirouz, Mehdi, Farache, Dorian, Franses, Joseph W, Kubaczka, Caroline, Tsanov, Kaloyan M, Jha, Deepak K, Pepe-Mooney, Brian, Powers, John T, Gregory, Richard I, Lee, Amy Sy, Dominguez, Daniel, Ting, David T, Daley, George Q

“…High expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing MYCN-amplified neuroblastoma as a model system, we showed…”
Get full text

Signaling through RNA-binding proteins as a cell fate regulatory mechanism by Tsanov, Kaloyan M., Daley, George Q.

Get full text

MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis by Barriga, Francisco M, Tsanov, Kaloyan M, Ho, Yu-Jui, Sohail, Noor, Zhang, Amy, Baslan, Timour, Wuest, Alexandra N, Del Priore, Isabella, Meškauskaitė, Brigita, Livshits, Geulah, Alonso-Curbelo, Direna, Simon, Janelle, Chaves-Perez, Almudena, Bar-Sagi, Dafna, Iacobuzio-Donahue, Christine A, Notta, Faiyaz, Chaligne, Ronan, Sharma, Roshan, Pe'er, Dana, Lowe, Scott W

“…The most prominent homozygous deletions in cancer affect chromosome 9p21.3 and eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to…”
Get full text

Lin28 paralogs regulate lung branching morphogenesis by Osborne, Jihan K., Kinney, Melissa A., Han, Areum, Akinnola, Kemi E., Yermalovich, Alena V., Vo, Linda T., Pearson, Daniel S., Sousa, Patricia M., Ratanasirintrawoot, Sutheera, Tsanov, Kaloyan M., Barragan, Jessica, North, Trista E., Metzger, Ross J., Daley, George Q.

“…The molecular mechanisms that govern the choreographed timing of organ development remain poorly understood. Our investigation of the role of the Lin28a and…”
Get full text

Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease by Leibold, Josef, Tsanov, Kaloyan M, Amor, Corina, Ho, Yu-Jui, Sánchez-Rivera, Francisco J, Feucht, Judith, Baslan, Timour, Chen, Hsuan-An, Tian, Sha, Simon, Janelle, Wuest, Alexandra, Wilkinson, John E, Lowe, Scott W

“…Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance,…”
Get full text

An embryonic stem cell-based system for rapid analysis of transcriptional enhancers by Tsanov, Kaloyan M., Nishi, Yuichi, Peterson, Kevin A., Liu, Jing, Baetscher, Manfred, McMahon, Andrew P.

“…With the growing use of genome‐wide screens for cis‐regulatory elements, there is a pressing need for platforms that enable fast and cost‐effective…”
Get full text

Abstract 3512: Organ-specific effects of Smad4 in metastatic pancreatic cancer by Tsanov, Kaloyan M., Barriga, Francisco M., Ho, Yu-Jui, Alonso-Curbelo, Direna, Livshits, Geulah, Koche, Richard, Baslan, Timour, Wuest, Alexandra N., Simon, Janelle, Tian, Sha, Luan, Wei, Lowe, Scott W.

“…Abstract Primary and metastatic tumors typically share the same driver gene mutations, but it is unclear if these mutations are functionally relevant across…”
Get full text

Abstract LB-290: Multiple distinct mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Roles, Frederik, Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theissen, Jessica, LaPier, Grace S., Pearson, Dan S., Berthold, Frank, Daley, George Q.

“…Abstract The let-7 microRNA family are known tumor suppressors often deregulated in cancer, yet the underlying mechanisms of let-7 disruption remain poorly…”
Get full text

Post-transcriptional Regulatory Mechanisms in the Control of Cell Identity by Tsanov, Kaloyan M

“…Cell identity is shaped by complex gene expression programs, at the core of which lies the set of messenger RNAs (mRNAs) expressed in a given cell. While there…”
Get full text