Search Results - "Tsang, Kit Y."

Efficient Formal Synthesis of the Human Telomerase Inhibitor (±)-γ-Rubromycin by Rathwell, Dominea C.K, Yang, Sung-Hyun, Tsang, Kit Y, Brimble, Margaret A

“…Balancing act: The correct balance of electronic factors in the naphthazarin and isocoumarin fragments facilitates the acid‐mediated spiroketalization step to…”
Get full text

Chiral Pool Based Synthesis of Platensimycin by Nicolaou, K.C, Pappo, Doron, Tsang, Kit Y, Gibe, Romelo, Chen, David Y.-K

“…Extensive pharming: An expedient entry into the tetracycle 2, a late‐stage synthetic intermediate en route to the broad‐spectrum antibiotic (−)‐platensimycin…”
Get full text

Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474 by Gamage, Swarna A., Giddens, Anna C., Tsang, Kit Y., Flanagan, Jack U., Kendall, Jackie D., Lee, Woo-Jeong, Baguley, Bruce C., Buchanan, Christina M., Jamieson, Stephen M.F., Shepherd, Peter R., Denny, William A., Rewcastle, Gordon W.

“…[Display omitted] Replacement of one of the morpholine groups of the phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474 (1) with sulfonamide containing…”
Get full text

Synthesis and Evaluation of Imidazo[1,2‐a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3‐Kinase Inhibitors by Gamage, Swarna A., Spicer, Julie A., Tsang, Kit Y., O'Connor, Patrick D., Flanagan, Jack U., Lee, Woo‐Jeong, Dickson, James M. J., Shepherd, Peter R., Denny, William A., Rewcastle, Gordon W.

“…Using a scaffold‐hopping approach, imidazo[1,2‐a]pyridine analogues of the ZSTK474 (benzimidazole) class of phosphatidylinositol 3‐kinase (PI3K) inhibitors…”
Get full text

Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors by Rewcastle, Gordon W, Kolekar, Sharada, Buchanan, Christina M, Gamage, Swarna A, Giddens, Anna C, Tsang, Kit Y, Kendall, Jackie D, Singh, Ripudaman, Lee, Woo-Jeong, Smith, Greg C, Han, Weiping, Matthews, David J, Denny, William A, Shepherd, Peter R, Jamieson, Stephen M F

“…Multiple therapeutic agents have been developed to target the phosphatidylinositol 3-kinase (PI3K) signaling pathway, which is frequently dysregulated in…”
Get full text

Use of a Sonogashira−Acetylide Coupling Strategy for the Synthesis of the Aromatic Spiroketal Skeleton of γ-Rubromycin by Tsang, Kit Y, Brimble, Margaret A, Bremner, John B

“…The synthesis of the fused aromatic spiroketal core of γ-rubromycin is described via addition of an aryl acetylide fragment to an aryl acetaldehyde fragment…”
Get full text

3-Allyl-2-hydroxy-5,6,8-trimethoxynaphthalene-1,4-dione by Rathwell, Dominea C. K., Tsang, Kit Y., Choi, Ka Wai, Boyd, Peter D. W., Brimble, Margaret A.

“…In the crystal structure of the title compound, C16H16O6, a pair of naphthoquinone rings are linked via O-H...O-C hydrogen bonds in a nearly orthogonal…”
Get full text

Synthesis and Evaluation of Imidazopyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3‐Kinase Inhibitors by Gamage, Swarna A, Spicer, Julie A, Tsang, Kit Y, O'Connor, Patrick D, Flanagan, Jack U, Woo‐Jeong Lee, Dickson, James M J, Shepherd, Peter R, Denny, William A, Rewcastle, Gordon W

“…Using a scaffold‐hopping approach, imidazo[1,2‐a]pyridine analogues of the ZSTK474 (benzimidazole) class of phosphatidylinositol 3‐kinase (PI3K) inhibitors…”
Get full text

A facile synthesis of fused aromatic spiroacetals based on the 3,4,3′,4′-tetrahydro-2,2′-spirobis(2 H-1-benzopyran) skeleton by Brimble, Margaret A., Flowers, Christopher L., Trzoss, Michael, Tsang, Kit Y.

“…The facile synthesis of a series of aromatic 6,6-spiroacetals based on the parent 3,4,3′,4′-tetrahydro-2,2′-spirobis(2 H-1-benzopyran) heterocyclic system is…”
Get full text

3-Allyl-2-hydr-oxy-5,6,8-trimethoxy-naphthalene-1,4-dione by Rathwell, Dominea C K, Tsang, Kit Y, Choi, Ka Wai, Boyd, Peter D W, Brimble, Margaret A

“…In the crystal structure of the title compound, C(16)H(16)O(6), a pair of naphthoquinone rings are linked via O-H⋯O-C hydrogen bonds in a nearly orthogonal…”
Get full text

An Efficient Formal Synthesis of the Human Telomerase Inhibitor (±)‐γ‐Rubromycin by Rathwell, Dominea C. K., Yang, Sung‐Hyun, Tsang, Kit Y., Brimble, Margaret A.

“…Balanceakt: Das Gleichgewicht der elektronischen Faktoren im Naphthazarin‐ und Isocumarin‐Fragment erleichtert die säurevermittelte Cyclisierung zum dicht…”
Get full text

A Chiral Pool Based Synthesis of Platensimycin by Nicolaou, K. C., Pappo, Doron, Tsang, Kit Y., Gibe, Romelo, Chen, David Y.-K.

“…Ein direkter Weg führt zu dem Tetracyclus 2, einer späten Zwischenstufe in der Synthese des Breitbandantibiotikums (−)‐Platensimycin (1). Zu diesem Zweck wird…”
Get full text

An Efficient Formal Synthesis of the Human Telomerase Inhibitor (±)‐γ‐Rubromycin by Rathwell, Dominea C. K., Yang, Sung‐Hyun, Tsang, Kit Y., Brimble, Margaret A.

Get full text

A Chiral Pool Based Synthesis of Platensimycin by Nicolaou, K. C., Pappo, Doron, Tsang, Kit Y., Gibe, Romelo, Chen, David Y.‐K.

Get full text