Search Results - "Tsang, Kit Y."

Efficient Formal Synthesis of the Human Telomerase Inhibitor (±)-γ-Rubromycin by Rathwell, Dominea C.K, Yang, Sung-Hyun, Tsang, Kit Y, Brimble, Margaret A

“…Balancing act: The correct balance of electronic factors in the naphthazarin and isocoumarin fragments facilitates the acid‐mediated spiroketalization step to…”
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Chiral Pool Based Synthesis of Platensimycin by Nicolaou, K.C, Pappo, Doron, Tsang, Kit Y, Gibe, Romelo, Chen, David Y.-K

“…Extensive pharming: An expedient entry into the tetracycle 2, a late‐stage synthetic intermediate en route to the broad‐spectrum antibiotic (−)‐platensimycin…”
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Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474 by Gamage, Swarna A., Giddens, Anna C., Tsang, Kit Y., Flanagan, Jack U., Kendall, Jackie D., Lee, Woo-Jeong, Baguley, Bruce C., Buchanan, Christina M., Jamieson, Stephen M.F., Shepherd, Peter R., Denny, William A., Rewcastle, Gordon W.

“…[Display omitted] Replacement of one of the morpholine groups of the phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474 (1) with sulfonamide containing…”
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Synthesis and Evaluation of Imidazo[1,2‐a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3‐Kinase Inhibitors by Gamage, Swarna A., Spicer, Julie A., Tsang, Kit Y., O'Connor, Patrick D., Flanagan, Jack U., Lee, Woo‐Jeong, Dickson, James M. J., Shepherd, Peter R., Denny, William A., Rewcastle, Gordon W.

“…Using a scaffold‐hopping approach, imidazo[1,2‐a]pyridine analogues of the ZSTK474 (benzimidazole) class of phosphatidylinositol 3‐kinase (PI3K) inhibitors…”
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Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors by Rewcastle, Gordon W, Kolekar, Sharada, Buchanan, Christina M, Gamage, Swarna A, Giddens, Anna C, Tsang, Kit Y, Kendall, Jackie D, Singh, Ripudaman, Lee, Woo-Jeong, Smith, Greg C, Han, Weiping, Matthews, David J, Denny, William A, Shepherd, Peter R, Jamieson, Stephen M F

“…Multiple therapeutic agents have been developed to target the phosphatidylinositol 3-kinase (PI3K) signaling pathway, which is frequently dysregulated in…”
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Use of a Sonogashira−Acetylide Coupling Strategy for the Synthesis of the Aromatic Spiroketal Skeleton of γ-Rubromycin by Tsang, Kit Y, Brimble, Margaret A, Bremner, John B

“…The synthesis of the fused aromatic spiroketal core of γ-rubromycin is described via addition of an aryl acetylide fragment to an aryl acetaldehyde fragment…”
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3-Allyl-2-hydroxy-5,6,8-trimethoxynaphthalene-1,4-dione by Rathwell, Dominea C. K., Tsang, Kit Y., Choi, Ka Wai, Boyd, Peter D. W., Brimble, Margaret A.

“…In the crystal structure of the title compound, C16H16O6, a pair of naphthoquinone rings are linked via O-H...O-C hydrogen bonds in a nearly orthogonal…”
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Synthesis and Evaluation of Imidazopyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3‐Kinase Inhibitors by Gamage, Swarna A, Spicer, Julie A, Tsang, Kit Y, O'Connor, Patrick D, Flanagan, Jack U, Woo‐Jeong Lee, Dickson, James M J, Shepherd, Peter R, Denny, William A, Rewcastle, Gordon W

“…Using a scaffold‐hopping approach, imidazo[1,2‐a]pyridine analogues of the ZSTK474 (benzimidazole) class of phosphatidylinositol 3‐kinase (PI3K) inhibitors…”
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A facile synthesis of fused aromatic spiroacetals based on the 3,4,3′,4′-tetrahydro-2,2′-spirobis(2 H-1-benzopyran) skeleton by Brimble, Margaret A., Flowers, Christopher L., Trzoss, Michael, Tsang, Kit Y.

“…The facile synthesis of a series of aromatic 6,6-spiroacetals based on the parent 3,4,3′,4′-tetrahydro-2,2′-spirobis(2 H-1-benzopyran) heterocyclic system is…”
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3-Allyl-2-hydr-oxy-5,6,8-trimethoxy-naphthalene-1,4-dione by Rathwell, Dominea C K, Tsang, Kit Y, Choi, Ka Wai, Boyd, Peter D W, Brimble, Margaret A

“…In the crystal structure of the title compound, C(16)H(16)O(6), a pair of naphthoquinone rings are linked via O-H⋯O-C hydrogen bonds in a nearly orthogonal…”
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An Efficient Formal Synthesis of the Human Telomerase Inhibitor (±)‐γ‐Rubromycin by Rathwell, Dominea C. K., Yang, Sung‐Hyun, Tsang, Kit Y., Brimble, Margaret A.

“…Balanceakt: Das Gleichgewicht der elektronischen Faktoren im Naphthazarin‐ und Isocumarin‐Fragment erleichtert die säurevermittelte Cyclisierung zum dicht…”
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A Chiral Pool Based Synthesis of Platensimycin by Nicolaou, K. C., Pappo, Doron, Tsang, Kit Y., Gibe, Romelo, Chen, David Y.-K.

“…Ein direkter Weg führt zu dem Tetracyclus 2, einer späten Zwischenstufe in der Synthese des Breitbandantibiotikums (−)‐Platensimycin (1). Zu diesem Zweck wird…”
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An Efficient Formal Synthesis of the Human Telomerase Inhibitor (±)‐γ‐Rubromycin by Rathwell, Dominea C. K., Yang, Sung‐Hyun, Tsang, Kit Y., Brimble, Margaret A.

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A Chiral Pool Based Synthesis of Platensimycin by Nicolaou, K. C., Pappo, Doron, Tsang, Kit Y., Gibe, Romelo, Chen, David Y.‐K.

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