Search Results - "Tsalkova, Tamara"

Epac and PKA: a tale of two intracellular cAMP receptors by Cheng, Xiaodong, Ji, Zhenyu, Tsalkova, Tamara, Mei, Fang

“…cAMP‐mediated signaling pathways regulate a multitude of important biological processes under both physiological and pathological conditions, including…”
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A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion by Almahariq, Muayad, Tsalkova, Tamara, Mei, Fang C, Chen, Haijun, Zhou, Jia, Sastry, Sarita K, Schwede, Frank, Cheng, Xiaodong

“…Exchange protein directly activated by cAMP (EPAC) and cAMP-dependent protein kinase (PKA) are two intracellular receptors that mediate the effects of the…”
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Isoform-specific antagonists of exchange proteins directly activated by cAMP by Tsalkova, Tamara, Mei, Fang C, Li, Sheng, Chepurny, Oleg G, Leech, Colin A, Liu, Tong, Holz, George G, Woods, Virgil L, Cheng, Xiaodong

“…The major physiological effects of cAMP in mammalian cells are transduced by two ubiquitously expressed intracellular cAMP receptors, protein kinase A (PKA)…”
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A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists by Tsalkova, Tamara, Mei, Fang C, Cheng, Xiaodong

“…The discovery, more than ten years ago, of exchange proteins directly activated by cAMP (EPAC) as a new family of intracellular cAMP receptors revolutionized…”
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Identification and Characterization of Small Molecules as Potent and Specific EPAC2 Antagonists by Chen, Haijun, Tsalkova, Tamara, Chepurny, Oleg G, Mei, Fang C, Holz, George G, Cheng, Xiaodong, Zhou, Jia

“…EPAC1 and EPAC2, two isoforms of exchange proteins directly activated by cAMP (EPAC), respond to the second messenger cAMP and regulate a wide variety of…”
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Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag by Chepurny, Oleg G, Bertinetti, Daniela, Diskar, Mandy, Leech, Colin A, Afshari, Parisa, Tsalkova, Tamara, Cheng, Xiaodong, Schwede, Frank, Genieser, Hans-G, Herberg, Friedrich W, Holz, George G

“…GPR119 is a G protein-coupled receptor expressed on enteroendocrine L-cells that synthesize and secrete the incretin hormone glucagon-like peptide-1 (GLP-1)…”
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Mechanism of Interactions of α-Naphthoflavone with Cytochrome P450 3A4 Explored with an Engineered Enzyme Bearing a Fluorescent Probe by Tsalkova, Tamara N, Davydova, Nadezhda Y, Halpert, James R, Davydov, Dmitri R

“…Design of a partially cysteine-depleted C98S/C239S/C377S/C468A cytochrome P450 3A4 mutant designated CYP3A4(C58,C64) allowed site-directed incorporation of…”
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Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP by White, Mark A, Li, Sheng, Tsalkova, Tamara, Mei, Fang C, Liu, Tong, Woods, Jr, Virgil L, Cheng, Xiaodong

“…Exchange proteins directly activated by cAMP (EPACs) are important allosteric regulators of cAMP-mediated signal transduction pathways. To understand the…”
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Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4 by Davydov, Dmitri R., Davydova, Nadezhda Y., Tsalkova, Tamara N., Halpert, James R.

“…Glutathione (GSH) exerted a profound effect on the oxidation of 7-benzyloxy-4-(trifluoromethyl)coumarin (BFC) and 7-benzyloxyquinoline (BQ) by human liver…”
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Mechanism of Intracellular cAMP Sensor Epac2 Activation by Li, Sheng, Tsalkova, Tamara, White, Mark A., Mei, Fang C., Liu, Tong, Wang, Daphne, Woods, Virgil L., Cheng, Xiaodong

“…Epac2, a guanine nucleotide exchange factor, regulates a wide variety of intracellular processes in response to second messenger cAMP. In this study, we have…”
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Mechanism of Epac Activation by Tsalkova, Tamara, Blumenthal, Donald K., Mei, Fang C., White, Mark A., Cheng, Xiaodong

“…Epac2 is a member of the family of exchange proteins directly activated by cAMP (Epac). Our previous studies suggest a model of Epac activation in which cAMP…”
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Developing Pharmacological Probes Targeting exchange protein directly activated by cAMP by Cheng, Xiaodong, Tsalkova, Tamara, Mei, Fang

“…Abstract only Cyclic adenosine monophosphate (cAMP), a prototypical second messenger, regulates a myriad of important biological processes under both…”
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5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP by Chen, Haijun, Tsalkova, Tamara, Mei, Fang C., Hu, Yaohua, Cheng, Xiaodong, Zhou, Jia

“…Exchange proteins directly activated by cAMP (Epac) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes…”
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Truncations at the NH2 Terminus of Rhodanese Destabilize the Enzyme and Decrease Its Heterologous Expression by Trevino, Richard J., Tsalkova, Tamara, Kramer, Gisela, Hardesty, Boyd, Chirgwin, John M., Horowitz, Paul M.

“…Rhodanese mutants containing sequential NH2-terminal deletions were constructed to test the distinct contributions of this region of the protein to expression,…”
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A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP by Tsalkova, Tamara, Mei, Fang C, Cheng, Xiaodong

“…Background The discovery, more than ten years ago, of exchange proteins directly activated by cAMP (EPAC) as a new family of intracellular cAMP receptors…”
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Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS) by Li, Sheng, Tsalkova, Tamara, White, Mark A, Mei, Fang C, Liu, Tong, Wang, Daphne, Woods, Jr, Virgil L, Cheng, Xiaodong

“…Epac2, a guanine nucleotide exchange factor, regulates a wide variety of intracellular processes in response to second messenger cAMP. In this study, we have…”
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Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology by White, Mark Andrew, Tsalkova, Tamara, Mei, Fang C, Cheng, Xiaodong

“…Exchange proteins directly activated by cAMP (EPAC1 and EPAC2) are important allosteric regulators of cAMP-mediated signal transduction pathways. To understand…”
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Mechanism of Epac Activation: STRUCTURAL AND FUNCTIONAL ANALYSES OF Epac2 HINGE MUTANTS WITH CONSTITUTIVE AND REDUCED ACTIVITIES by Tsalkova, Tamara, Blumenthal, Donald K, Mei, Fang C, White, Mark A, Cheng, Xiaodong

“…Epac2 is a member of the family of exchange proteins directly activated by cAMP (Epac). Our previous studies suggest a model of Epac activation in which cAMP…”
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Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs by Tsalkova, Tamara, Gribenko, Alexey V, Cheng, Xiaodong

“…It has been reported by Zhang et al. that antidiabetic sulfonylurea drugs promote insulin secretion by directly binding to exchange protein directly activated…”
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The Many Conformations of Epac2: A Cyclic-AMP Sensing Cellular Regulator Studied Via Solution X-Ray Scattering (SAXS) & Hydrogen Deuterium Exchange Mass Spectrometry by White, Mark A., Cheng, Xiaodong, Tsalkova, Tamara, Mei, Feng C., Woods, Virgil L., Li, Sheng, Liu, Tong, Blumenthal, Donald K.

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