Search Results - "Tsakiridis, T."

Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK by Storozhuk, Y, Hopmans, S N, Sanli, T, Barron, C, Tsiani, E, Cutz, J-C, Pond, G, Wright, J, Singh, G, Tsakiridis, T

“…Background: We examined the potential of metformin (MET) to enhance non-small cell lung cancer (NSCLC) responses to ionising radiation (IR). Methods: Human…”
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Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial by Brand, Douglas H, Tree, Alison C, Ostler, Peter, van der Voet, Hans, Loblaw, Andrew, Chu, William, Ford, Daniel, Tolan, Shaun, Jain, Suneil, Martin, Alexander, Staffurth, John, Camilleri, Philip, Kancherla, Kiran, Frew, John, Chan, Andrew, Dayes, Ian S, Henderson, Daniel, Brown, Stephanie, Cruickshank, Clare, Burnett, Stephanie, Duffton, Aileen, Griffin, Clare, Hinder, Victoria, Morrison, Kirsty, Naismith, Olivia, Hall, Emma, van As, Nicholas, Dodds, D, Lartigau, E, Patton, S, Thompson, A, Winkler, M, Wells, P, Lymberiou, T, Saunders, D, Vilarino-Varela, M, Vavassis, P, Tsakiridis, T, Carlson, R, Rodrigues, G, Tanguay, J, Iqbal, S, Morgan, S, Mihai, A, Li, A, Din, O, Panades, M, Wade, R, Rimmer, Y, Armstrong, J, Oommen, N

“…Localised prostate cancer is commonly treated with external-beam radiotherapy. Moderate hypofractionation has been shown to be non-inferior to conventional…”
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Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial by Tree, Alison C, Ostler, Peter, van der Voet, Hans, Chu, William, Loblaw, Andrew, Ford, Daniel, Tolan, Shaun, Jain, Suneil, Martin, Alexander, Staffurth, John, Armstrong, John, Camilleri, Philip, Kancherla, Kiran, Frew, John, Chan, Andrew, Dayes, Ian S, Duffton, Aileen, Brand, Douglas H, Henderson, Daniel, Morrison, Kirsty, Brown, Stephanie, Pugh, Julia, Burnett, Stephanie, Mahmud, Muneeb, Hinder, Victoria, Naismith, Olivia, Hall, Emma, van As, Nicholas, Lartigau, E, Patton, S, Thompson, A, Winkler, M, Wells, P, Lymberiou, T, Saunders, D, Vilarino-Varela, M, Vavassis, P, Tsakiridis, T, Carlson, R, Rodrigues, G, Tanguay, J, Iqbal, S, Morgan, S, Mihai, A, Li, A, Din, O, Panades, M, Wade, R, Rimmer, Y, Oommen, N

“…Localised prostate cancer is commonly treated with external beam radiotherapy and moderate hypofractionation is non-inferior to longer schedules. Stereotactic…”
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Predicting 2-Year Survival for Radiation Regimens in Advanced Non-small Cell Lung Cancer by Sharieff, W, Okawara, G, Tsakiridis, T, Wright, J

“…Abstract Aims Total dose, dose per fraction, number of fractions and treatment time are important determinants of the biological effect of a radiation regimen…”
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Pulmonary Function Test and Its Predictive Factors in Patients With Lung Malignancies Treated With Stereotactic Radiation Therapy: A Retrospective Review From a Single Institution by Nguyen, N, Tsakiridis, T, Zhang, H, Anand, S, Okawara, G, Corbett, T, Wright, J

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Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway by Estrada, D. E., Ewart, H. S., Tsakiridis, T., Volchuk, A., Ramlal, T., Tritschler, H., Klip, A.

“…Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. D E Estrada…”
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Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane by Tsakiridis, T, Vranic, M, Klip, A

“…In muscle and fat tissues, insulin stimulates glucose transport through the translocation of glucose transporter proteins from an intracellular storage pool to…”
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Influence of Gold Seed Implantation on Defining Target Volumes for Conformal Radiotherapy of Prostate Cancer by Pan, M, Lukka, H, Corbett, T, Patel, M, Tsakiridis, T, Dayes, I

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Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells by Tsakiridis, T, McDowell, H E, Walker, T, Downes, C P, Hundal, H S, Vranic, M, Klip, A

“…Phosphatidylinositol 3-kinase (PI3k) activity is required for the insulin stimulation of glucose transport in adipocytes and Chinese hamster ovary cells…”
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Phosphatidylinositol 3-kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with insulin action by Tsakiridis, T, Vranic, M, Klip, A

“…In L6 myotubes insulin stimulates glucose transport through the translocation of glucose transporters GLUT1, GLUT3 and GLUT4 from intracellular stores to the…”
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Circulating Growth Differentiation Factor 15 as a Biomarker in Patients with Unresected Locally Advanced Non-Small Cell Lung Cancer Treated with Chemo-Radiotherapy with or without Metformin by Di Pastena, F., Pond, G., Ahmadi, E., Tsakiridis, E.E., Steinberg, G.R., Tsakiridis, T.

“…Growth differentiation factor 15 (GDF15) is a member of the TGFβ family suggested to have prognostic value in cancer. Plasma GDF15 levels are elevated in…”
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Cardiac Toxicity in Central Non-Small Cell Lung Tumors treated with Stereotactic Body Radiation Therapy (SBRT) – Is there a “No-Flutter Zone”? by Donovan, E., Okawara, G.S., Wright, J., Tsakiridis, T., Swaminath, A.

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Glucose transporter expression in L6 muscle cells: regulation through insulin- and stress-activated pathways by Taha, C, Tsakiridis, T, McCall, A, Klip, A

“…We addressed the effect of long-term treatment with insulin, 2,4-dinitrophenol (DNP; an uncoupler of oxidative phosphorylation that increases energy demand)…”
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Radiation Dose, Technique and Use of Brain Radiation on Overall Survival in Patients with Limited-Stage Small Cell Lung Cancer by Palchik, S., Pond, G., Wu, C.H.D., Wright, J., Tsakiridis, T., Swaminath, A.

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Progression-Free Survival as a Surrogate Endpoint of Overall Survival in Patients with Locally Advanced Non-Small Cell Lung Cancer Treated with Chemoradiotherapy: Trial-Level Meta-Analysis and Individual-Level Analysis of NRG/RTOG 0617 and PROCLAIM by Hu, C., Miccio, J.A., Dignam, J.J., Paulus, R., Liu, C., Skinner, H.D., Tsakiridis, T., Bradley, J.D., Machtay, M.

“…Overall Survival (OS) is the gold standard endpoint in randomized clinical trials (RCTs) of Locally Advanced Non-Small Cell Lung Cancer (LA-NSCLC)…”
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Forecasted Global Brachytherapy Shortfall by 2040: Investments Needed to Overcome this Deficit by Gouveia, A.G., Viani, G., DelRosso, D., Marta, G.N., Tsakiridis, T., Quan, K., Hanna, S.A., de Sousa, C.F.P.M., Starling, M.T.M., Silva, M.F., Rosa, A.A., Moraes, F.Y.

“…Between 2020 and 2040, it is estimated that there will be a significant worldwide increase of 34.1% in the annual incidence of cervical and endometrial…”
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Geographical Disparities in Access to Radiotherapy in Brazil: An Observational Study by Gouveia, A.G., DelRosso, D., Viani, G., Silva, M.F., Rosa, A.A., Marta, G.N., Castilho, M.S., Tsakiridis, T., Starling, M.T.M., de Sousa, C.F.P.M., Hanna, S.A., Moraes, F.Y.

“…This observational study evaluates disparities in access to radiotherapy in Brazil, focusing on the distances traveled by patients for treatment. Utilizing…”
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Exercise increases the plasma membrane content of the Na+ -K+ pump and its mRNA in rat skeletal muscles by Tsakiridis, T, Wong, P P, Liu, Z, Rodgers, C D, Vranic, M, Klip, A

“…Muscle fibers adapt to ionic challenges of exercise by increasing the plasma membrane Na+-K+ pump activity. Chronic exercise training has been shown to…”
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The Role of FDG-PET in Staging and Treatment for Stage III NSCLC in Ontario, Canada Between 2009-2017 by Beers, C.A., Pond, G., Wright, J., Tsakiridis, T., Okawara, G.S., Swaminath, A.

“…Fluoro-2-deoxyglucose positron-emission tomography (PET) is now considered standard of care in the staging evaluation for new cases of stage III NSCLC however,…”
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Stereotactic Body Radiotherapy (SBRT) vs. Conventional Fractionation External Beam Radiotherapy (EBRT) Boost for Unfavorable Intermediate and High-Risk Prostate Cancer; Early Results of PBS: A Phase II Randomized Trial (NCT03380806) by Gouveia, A.G., Mesci, A., Isfahanian, N., Dayes, I., Quan, K., Goldberg, M., Schnarr, K.L., Lukka, H., Cuthbert, D., Hallock, A., Douvi, G., Wright, J., Swaminath, A., Chow, T., Diamond, K., Hajdok, G., Maharaj, L., Ewusive, J., Tsakiridis, T.

“…Treatment of high-risk (HR) prostate cancer (PC) usually involves pelvic conventional fractionation (CF)-EBRT, followed by CF-EBRT boost to prostate in…”
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