Search Results - "Tsai, Yvonne C."

The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2 by FRIEDMAN, Jeffrey M, GANGNING LIANG, LIU, Chun-Chi, WOLFF, Erika M, TSAI, Yvonne C, WEI YE, XIANGHONG ZHOU, JONES, Peter A

“…The Polycomb Repressive Complex 2 (PRC2) mediates epigenetic gene silencing by trimethylating histone H3 lysine 27 (H3K27me3) and is known to aberrantly…”
Get full text

Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma by Gujar, Hemant, Mehta, Arjun, Li, Hong-Tao, Tsai, Yvonne C, Qiu, Xiangning, Weisenberger, Daniel J, Jasiulionis, Miriam Galvonas, In, Gino K, Liang, Gangning

“…Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with limited treatment possibilities. Merkel cell tumors display with neuroendocrine features…”
Get full text

Role of Nucleosomal Occupancy in the Epigenetic Silencing of the MLH1 CpG Island by Lin, Joy C., Jeong, Shinwu, Liang, Gangning, Takai, Daiya, Fatemi, Merhnaz, Tsai, Yvonne C., Egger, Gerda, Gal-Yam, Einav Nili, Jones, Peter A.

“…Epigenetic silencing of tumor suppressor genes is generally thought to involve DNA cytosine methylation, covalent modifications of histones, and chromatin…”
Get full text

Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements by Liang, Gangning, Chan, Matilda F., Tomigahara, Yoshitaka, Tsai, Yvonne C., Gonzales, Felicidad A., Li, En, Laird, Peter W., Jones, Peter A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Detection of Methylated Apoptosis-Associated Genes in Urine Sediments of Bladder Cancer Patients by FRIEDRICH, Martin G, WEISENBERGER, Daniel J, NICHOLS, Peter W, BOCHNER, Bernard H, JONES, Peter A, GANGNING LIANG, CHENG, Jonathan C, CHANDRASOMA, Shahin, SIEGMUND, Kimberly D, GONZALGO, Mark L, TOMA, Marieta I, HULAND, Hartwig, YOO, Christine, TSAI, Yvonne C

“…Purpose: There is increasing evidence for a fundamental role for epigenetic silencing of apoptotic pathways in cancer. Changes in DNA methylation can be…”
Get full text

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines : possible implications for role as tumor suppressor gene by KISSIL, J. L, FEINSTEIN, E, COHEN, O, JONES, P. A, TSAI, Y. C, KNOWLES, M. A, EYDMANN, M. E, KIMCHI, A

“…DAP-kinase is a novel calmodulin dependent serine/threonine kinase that carries ankyrin repeats and the death domain. It was recently isolated, by a functional…”
Get full text

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples by Sidransky, David, Von Eschenbach, Andrew, Tsai, Yvonne C., Jones, Peter, Summerhayes, Ian, Marshall, Fray, Paul, Meera, Green, Pearl, Hamilton, Stanley R., Frost, Philip, Vogelstein, Bert

“…Although bladder cancers are very common, little is known about their molecular pathogenesis. In this study, invasive bladder cancers were evaluated for the…”
Get full text

Evidence for Multiclonality in Multicentric Kaposi's Sarcoma by Gill, Parkash S., Tsai, Yvonne C., Rao, Adupa P., Spruck, Charles H., Zheng, Tong, Harrington, William A., Cheung, Tony, Nathwani, Bharat, Jones, Peter A.

“…Kaposi's sarcoma (KS) develops in a variety of clinical states and is the most common tumor seen in patients with HIV-1 infection. KS develops as a multifocal…”
Get full text

Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells by Weisenberger, Daniel J., Velicescu, Mihaela, Preciado-Lopez, Miguel A., Gonzales, Felicidad A., Tsai, Yvonne C., Liang, Gangning, Jones, Peter A.

“…CpG methylation is mediated by the functions of at least three active DNA methyltransferases (DNMTs). While DNMT1 is thought to perform maintenance…”
Get full text

Reprogramming of the human intestinal epigenome by surgical tissue transposition by Lay, Fides D, Triche, Jr, Timothy J, Tsai, Yvonne C, Su, Sheng-Fang, Martin, Sue Ellen, Daneshmand, Siamak, Skinner, Eila C, Liang, Gangning, Chihara, Yoshitomo, Jones, Peter A

“…Extracellular cues play critical roles in the establishment of the epigenome during development and may also contribute to epigenetic perturbations found in…”
Get full text

RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking by Wolff, Erika M, Liang, Gangning, Cortez, Connie C, Tsai, Yvonne C, Castelao, J Esteban, Cortessis, Victoria K, Tsao-Wei, Denice D, Groshen, Susan, Jones, Peter A

“…Exposure to tobacco smoke is associated with increased DNA methylation at certain genes in both lung and bladder tumors. We sought to identify interactions in…”
Get full text

Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer by TAKAI, Daiya, GONZALES, Felicidad A, TSAI, Yvonne C, THAYER, Mathew J, JONES, Peter A

“…The methylation status of binding sites of the insulator protein, CTCF, in the H19 promoter has been suggested as being critical to the regulation of…”
Get full text

Cell division is required for de novo methylation of CpG islands in bladder cancer cells by VELICESCU, Mihaela, WEISENBERGER, Daniel J, GONZALES, Felicidad A, TSAI, Yvonne C, NGUYEN, Carvell T, JONES, Peter A

“…Cell division is essential for tumor development and progression. Methylation-mediated silencing caused by aberrant de novo methylation of CpG islands located…”
Get full text

The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines by GONZALGO, M. L, HAYASHIDA, T, BENDER, C. M, PAO, M. M, TSAI, Y. C, GONZALES, F. A, NGUYEN, H. D, NGUYEN, T. T, JONES, P. A

“…Methylation of CpG sites in the control regions of tumor suppressor genes may be an important mechanism for their heritable, yet reversible, transcriptional…”
Get full text

Two molecular pathways to transitional cell carcinoma of the bladder by SPRUCK, C. H, OHNESEIT, P. F, DUBEAU, L, NICHOLS, P. W, HERMANN, G. G, STEVEN, K, HORN, T, SKINNER, D. G, JONES, P. A, GONZALEZ-ZULUETA, M, ESRIG, D, MIYAO, N, TSAI, Y. C, LERNER, S. P, SCHMÜTTE, C, YANG, A. S, COTE, R

“…Noninvasive transitional cell carcinomas of the bladder can have two distinct morphologies suggesting they contain different genetic alterations. Papillary…”
Get full text

P16 gene in uncultured tumours by Spruck, Charles H, Gonzalez-Zulueta, Mirella, Shibata, Atsuko, Simoneau, Anne R, Lin, Ming-Fong, Gonzales, Felicidad, Tsai, Yvonne C, Jones, Peter A

Get full text

Progressive increases in de novo methylation of CpG islands in bladder cancer by SALEM, C, GANGNING LIANG, TSAI, Y. C, COULTER, J, KNOWLES, M. A, FENG, A.-C, GROSHEN, S, NICHOLS, P. W, JONES, P. A

“…We conducted a quantitative analysis of the extent of de novo methylation of four CpG islands in human urinary transitional cell carcinomas of different stages…”
Get full text

Contiguous patches of normal human mammary epithelium derived from a single stem cell : implications for breast carcinogenesis by TSAI, Y. C, YOU LU, NICHOLS, P. W, ZLOTNIKOV, G, JONES, P. A, SMITH, H. S

“…Tissue clonality can be assessed in females by analyzing the methylation status of polymorphic DNA markers on X-linked genes because extensive de novo…”
Get full text

Microsatellite instability in bladder cancer by GONZALEZ-ZULUETA, M, RUPPERT, J. M, SUMMERHAYES, I. C, SIDRANSKY, D, JONES, P. A, TOKINO, K, TSAI, Y. C, SPRUCK, C. H, MIYAO, N, NICHOLS, P. W, HERMANN, G. G, HORN, T, STEVEN, K

“…Somatic instability at microsatellite repeats was detected in 6 of 200 transitional cell carcinomas of the bladder. Instabilities were apparent as changes in…”
Get full text

Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations by SIMONEAU, A. R, SPRUCK, C. H, GONZALEZ-ZULUETA, M, GONZALGO, M. L, CHAN, M. F, TSAI, Y. C, DEAN, M, STEVEN, K, HORN, T, JONES, P. A

“…The most common genetic alteration identified to date in bladder cancer is loss of heterozygosity (LOH) of chromosome 9, suggesting the presence of possible…”
Get full text