Search Results - "Tsai, Yu‐Hsuan"

Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines by Patel, Sanjay G., Sayers, Edward J., He, Lin, Narayan, Rohan, Williams, Thomas L., Mills, Emily M., Allemann, Rudolf K., Luk, Louis Y. P., Jones, Arwyn T., Tsai, Yu-Hsuan

“…Protein therapy holds great promise for treating a variety of diseases. To act on intracellular targets, therapeutic proteins must cross the plasma membrane…”
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Selective, rapid and optically switchable regulation of protein function in live mammalian cells by Tsai, Yu-Hsuan, Essig, Sebastian, James, John R., Lang, Kathrin, Chin, Jason W.

“…The rapid and selective regulation of a target protein within living cells that contain closely related family members is an outstanding challenge. Here we…”
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Approaches for peptide and protein cyclisation by Hayes, Heather C, Luk, Louis Y P, Tsai, Yu-Hsuan

“…The cyclisation of polypeptides can play a crucial role in exerting biological functions, maintaining stability under harsh conditions and conferring…”
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Secondary Amine Catalysis in Enzyme Design: Broadening Protein Template Diversity through Genetic Code Expansion by Williams, Thomas L., Taily, Irshad M., Hatton, Lewis, Berezin, Andrey A, Wu, Yi‐Lin, Moliner, Vicent, Świderek, Katarzyna, Tsai, Yu‐Hsuan, Luk, Louis Y. P.

“…Secondary amines, due to their reactivity, can transform protein templates into catalytically active entities, accelerating the development of artificial…”
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Modeling water quality in an urban river using hydrological factors – Data driven approaches by Chang, Fi-John, Tsai, Yu-Hsuan, Chen, Pin-An, Coynel, Alexandra, Vachaud, Georges

“…Contrasting seasonal variations occur in river flow and water quality as a result of short duration, severe intensity storms and typhoons in Taiwan. Sudden…”
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Reactivity and Selectivity of Iminium Organocatalysis Improved by a Protein Host by Nödling, Alexander R., Świderek, Katarzyna, Castillo, Raquel, Hall, Jonathan W., Angelastro, Antonio, Morrill, Louis C., Jin, Yi, Tsai, Yu‐Hsuan, Moliner, Vicent, Luk, Louis Y. P.

“…There has been growing interest in performing organocatalysis within a supramolecular system as a means of controlling reaction reactivity and…”
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Chemical Biology of Glycosylphosphatidylinositol Anchors by Tsai, Yu-Hsuan, Liu, Xinyu, Seeberger, Peter H.

“…Glycosylphosphatidylinositols (GPIs) are complex glycolipids that are covalently linked to the C‐terminus of proteins as a posttranslational modification. They…”
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Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells by Nödling, Alexander R, Spear, Luke A, Williams, Thomas L, Luk, Louis Y P, Tsai, Yu-Hsuan

“…Genetic code expansion allows unnatural (non-canonical) amino acid incorporation into proteins of interest by repurposing the cellular translation machinery…”
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Acetylation at Lysine 86 of Escherichia coli HUβ Modulates the DNA-Binding Capability of the Protein by Barlow, Victoria L, Tsai, Yu-Hsuan

“…DNA-binding protein HU is highly conserved in bacteria and has been implicated in a range of cellular processes and phenotypes. Like eukaryotic histones, HU is…”
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Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes by Nödling, Alexander R, Mills, Emily M, Li, Xuefei, Cardella, Davide, Sayers, Edward J, Wu, Shih-Hsiung, Jones, Arwyn T, Luk, Louis Y P, Tsai, Yu-Hsuan

“…Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of common cyanine dyes Cy3 and Cy5 as vectors for targeting…”
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Effect of membrane fusion protein AdeT1 on the antimicrobial resistance of Escherichia coli by Barlow, Victoria L., Lai, Shu-Jung, Chen, Chia-Yu, Tsai, Cheng-Han, Wu, Shih-Hsiung, Tsai, Yu-Hsuan

“…Acinetobacter baumannii is a prevalent pathogen that can rapidly acquire resistance to antibiotics. Indeed, multidrug-resistant A. baumannii is a major cause…”
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The deficiency of poly-β-1,6-N-acetyl-glucosamine deacetylase trigger A. baumannii to convert to biofilm-independent colistin-tolerant cells by Lai, Shu-Jung, Tu, I-Fan, Tseng, Tien-Sheng, Tsai, Yu-Hsuan, Wu, Shih-Hsiung

“…Acinetobacter baumannii is a nosocomial pathogen that can be resistant to antibiotics by rapidly modulating its anti-drug mechanisms. The multidrug-resistant…”
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Butterflies in the gut: the interplay between intestinal microbiota and stress by Lai, Tzu-Ting, Liou, Chia-Wei, Tsai, Yu-Hsuan, Lin, Yuan-Yuan, Wu, Wei-Li

“…Psychological stress is a global issue that affects at least one-third of the population worldwide and increases the risk of numerous psychiatric disorders…”
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Spatio‐Temporal Photoactivation of Cytotoxic Proteins by Cruz‐Samperio, Raquel, Mart, Robert J., Luk, Louis Y. P., Tsai, Yu‐Hsuan, Jones, Arwyn T., Allemann, Rudolf K.

“…Protein therapeutics offer exquisite selectivity in targeting cellular processes and behaviors, but are rarely used against non‐cell surface targets due to…”
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Dual GRIN lens two-photon endoscopy for high-speed volumetric and deep brain imaging by Chien, Yu-Feng, Lin, Jyun-Yi, Yeh, Po-Ting, Hsu, Kuo-Jen, Tsai, Yu-Hsuan, Chen, Shih-Kuo, Chu, Shi-Wei

“…Studying neural connections and activities is fundamental to understanding brain functions. Given the cm-size brain and three-dimensional neural circuit…”
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Editorial: Chemical Biology Tools for Peptide and Protein Research by Tsai, Yu-Hsuan, Iwaï, Hideo, Pors, Klaus

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IL-33/ST2 Axis Plays a Protective Effect in Streptococcus pyogenes Infection through Strengthening of the Innate Immunity by Kuo, Chih-Feng, Chen, Wei-Yu, Yu, Hai-Han, Tsai, Yu-Hsuan, Chang, Ya-Chu, Chang, Chih-Peng, Tsao, Nina

“…Group A (GAS) causes invasive human diseases with the cytokine storm. Interleukin-33 (IL-33)/suppression of tumorigenicity 2 (ST2) axis is known to drive T 2…”
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Transferability of N-terminal mutations of pyrrolysyl-tRNA synthetase in one species to that in another species on unnatural amino acid incorporation efficiency by Williams, Thomas L., Iskandar, Debra J., Nödling, Alexander R., Tan, Yurong, Luk, Louis Y. P., Tsai, Yu-Hsuan

“…Genetic code expansion is a powerful technique for site-specific incorporation of an unnatural amino acid into a protein of interest. This technique relies on…”
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Applying switchable Cas9 variants to in vivo gene editing for therapeutic applications by Mills, Emily M., Barlow, Victoria L., Luk, Louis Y. P., Tsai, Yu-Hsuan

“…Progress in targeted gene editing by programmable endonucleases has paved the way for their use in gene therapy. Particularly, Cas9 is an endonuclease with…”
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Work hours and turnover intention among hospital physicians in Taiwan: does income matter? by Tsai, Yu-Hsuan, Huang, Nicole, Chien, Li-Yin, Chiang, Jen-Huai, Chiou, Shu-Ti

“…Physician shortage has become an urgent and critical challenge to many countries. According to the workforce dynamic model, long work hours may be one major…”
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