Search Results - "Tsai, Susan"

Importance of Lean Body Mass in the Oncologic Patient by Tsai, Susan

“…Loss of lean body develops from an imbalance in protein synthesis and catabolism and is associated with a variety of different disease and nondisease states,…”
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Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models by Tsai, Susan, McOlash, Laura, Palen, Katie, Johnson, Bryon, Duris, Christine, Yang, Qiuhui, Dwinell, Michael B, Hunt, Bryan, Evans, Douglas B, Gershan, Jill, James, Michael A

“…Patient-derived tumor models are the new standard for pre-clinical drug testing and biomarker discovery. However, the emerging technology of primary pancreatic…”
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Non-metastatic Pancreatic Cancer: Resectable, Borderline Resectable, and Locally Advanced-Definitions of Increasing Importance for the Optimal Delivery of Multimodality Therapy by Evans, Douglas B., George, Ben, Tsai, Susan

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Plasma extracellular RNA profiles in healthy and cancer patients by Yuan, Tiezheng, Huang, Xiaoyi, Woodcock, Mark, Du, Meijun, Dittmar, Rachel, Wang, Yuan, Tsai, Susan, Kohli, Manish, Boardman, Lisa, Patel, Tushar, Wang, Liang

“…Extracellular vesicles are selectively enriched in RNA that has potential as disease biomarkers. To systemically characterize circulating extracellular RNA…”
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Circulating giant macrophages as a potential biomarker of solid tumors by Adams, Daniel L., Martin, Stuart S., Alpaugh, Katherine, Charpentier, Monica, Tsai, Susan, Bergan, Raymond C., Ogden, Irene M., Catalona, William, Chumsri, Saranya, Tang, Cha-Mei, Cristofanilli, Massimo

“…Tumor-associated macrophages (TAMs) derived from primary tumors are believed to facilitate circulating tumor cell (CTC) seeding of distant metastases, but the…”
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Neoadjuvant FOLFIRINOX for Borderline Resectable Pancreas Cancer: A New Treatment Paradigm? by Christians, Kathleen K., Tsai, Susan, Mahmoud, Anna, Ritch, Paul, Thomas, James P., Wiebe, Lauren, Kelly, Tracy, Erickson, Beth, Wang, Huamin, Evans, Douglas B., George, Ben

“…Background. Borderline resectable pancreatic cancer is best treated by multimodality therapy. FOLFIRINOX (5‐fluorouracil, oxaliplatin, irinotecan, and…”
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CXCR4 expression in tumor associated cells in blood is prognostic for progression and survival in pancreatic cancer by Gardner, Kirby P, Tsai, Susan, Aldakkak, Mohammed, Gironda, Stephen, Adams, Daniel L

“…The aggressive nature and metastatic potential of pancreatic cancer (PC) results in poor prognosis and high mortality. A better understanding of the underlying…”
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A Phase II Clinical Trial of Molecular Profiled Neoadjuvant Therapy for Localized Pancreatic Ductal Adenocarcinoma by Tsai, Susan, Christians, Kathleen K, George, Ben, Ritch, Paul S, Dua, Kulwinder, Khan, Abdul, Mackinnon, A Craig, Tolat, Parag, Ahmad, Syed A, Hall, William A, Erickson, Beth A, Evans, Douglas B

“…OBJECTIVES:One facet of precision medicine is the use of tumor molecular profiling to guide chemotherapeutic selection. We conducted the first prospective…”
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A machine learning based delta-radiomics process for early prediction of treatment response of pancreatic cancer by Nasief, Haidy, Zheng, Cheng, Schott, Diane, Hall, William, Tsai, Susan, Erickson, Beth, Allen Li, X.

“…Changes of radiomic features over time in longitudinal images, delta radiomics, can potentially be used as a biomarker to predict treatment response. This…”
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Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability by Wu, Pui-Kei, Hong, Seung-Keun, Starenki, Dmytro, Oshima, Kiyoko, Shao, Hao, Gestwicki, Jason E., Tsai, Susan, Park, Jong-In

“…The mitochondrial HSP70 chaperone mortalin (HSPA9/GRP75) is often upregulated and mislocalized in MEK/ERK-deregulated tumors. Here, we show that mortalin…”
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Survival of patients with resectable pancreatic cancer who received neoadjuvant therapy by Christians, Kathleen K., MD, Heimler, Jonathan W, George, Ben, MD, Ritch, Paul S., MD, Erickson, Beth A., MD, Johnston, Fabian, MD, Tolat, Parag P., MD, Foley, William D., MD, Evans, Douglas B., MD, Tsai, Susan, MD, MS

“…Background Enthusiasm for neoadjuvant therapy is growing from the emerging consensus that pancreatic cancer is a systemic disease at the time of diagnosis…”
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Pancreatobiliary Maljunction-Associated Gallbladder Cancer is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-Induced Reflux-Associated Physio-Chemical Carcinogenesis by Muraki, Takashi, Pehlivanoglu, Burcin, Memis, Bahar, Reid, Michelle D, Uehara, Takeshi, Basturk, Olca, Pernicka, Jennifer Golia, Klimstra, David S, Jarnagin, William R, Ito, Tetsuya, Hasebe, Osamu, Okaniwa, Shinji, Horigome, Naoto, Hisa, Takeshi, Mittal, Pardeep, Sarmiento, Juan M, Maithel, Shishir K, Koshiol, Jill, Tsai, Susan, Evans, Douglas, Erkan, Mert, Adsay, Volkan

“…OBJECTIVE:To determine the associations of pancreatobiliary maljunction (PBM) in the West. BACKGROUND:PBM (anomalous union of common bile duct and pancreatic…”
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Arterial resection at the time of pancreatectomy for cancer by Christians, Kathleen K., MD, Pilgrim, Charles H.C., MD, PhD, Tsai, Susan, MD, MS, Ritch, Paul, MD, George, Ben, MD, Erickson, Beth, MD, Tolat, Parag, MD, Evans, Douglas B., MD

“…Background Tumor-induced arterial abutment/encasement has been traditionally a contraindication to surgery in patients with localized pancreatic cancer (PC)…”
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Chemotherapy for Surgically Resected Intrahepatic Cholangiocarcinoma by Miura, John T., Johnston, Fabian M., Tsai, Susan, George, Ben, Thomas, Jim, Eastwood, Dan, Banerjee, Anjishnu, Christians, Kathleen K., Turaga, Kiran K., Pawlik, Timothy M., Clark Gamblin, T.

“…Background The benefit of chemotherapy for surgically resected intrahepatic cholangiocarcinoma (ICC) remains poorly defined. The present study sought to…”
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Improving Treatment Response Prediction for Chemoradiation Therapy of Pancreatic Cancer Using a Combination of Delta-Radiomics and the Clinical Biomarker CA19-9 by Nasief, Haidy, Hall, William, Zheng, Cheng, Tsai, Susan, Wang, Liang, Erickson, Beth, Li, X Allen

“…Recently we showed that delta radiomics features (DRF) from daily CT-guided chemoradiation therapy (CRT) is associated with early prediction of treatment…”
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Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment by Sharick, Joe T., Walsh, Christine M., Sprackling, Carley M., Pasch, Cheri A., Pham, Dan L., Esbona, Karla, Choudhary, Alka, Garcia-Valera, Rebeca, Burkard, Mark E., McGregor, Stephanie M., Matkowskyj, Kristina A., Parikh, Alexander A., Meszoely, Ingrid M., Kelley, Mark C., Tsai, Susan, Deming, Dustin A., Skala, Melissa C.

“…New tools are needed to match cancer patients with effective treatments. Patient-derived organoids offer a high-throughput platform to personalize treatments…”
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Techniques of Vascular Resection and Reconstruction in Pancreatic Cancer by Younan, George, MD, Tsai, Susan, MD, MHS, Evans, Douglas B., MD, Christians, Kathleen K., MD

“…Multimodality therapy has become the standard approach for the treatment of pancreatic cancer. With improved response rates to newer chemotherapeutic agents,…”
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Automated machine learning (AutoML) can predict 90-day mortality after gastrectomy for cancer by SenthilKumar, Gopika, Madhusudhana, Sharadhi, Flitcroft, Madelyn, Sheriff, Salma, Thalji, Samih, Merrill, Jennifer, Clarke, Callisia N., Maduekwe, Ugwuji N., Tsai, Susan, Christians, Kathleen K., Gamblin, T. Clark, Kothari, Anai N.

“…Early postoperative mortality risk prediction is crucial for clinical management of gastric cancer. This study aims to predict 90-day mortality in gastric…”
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Sarcopenia negatively impacts short-term outcomes in patients undergoing hepatic resection for colorectal liver metastasis by Peng, Peter D, van Vledder, Mark G, Tsai, Susan, de Jong, Mechteld C, Makary, Martin, Ng, Julie, Edil, Barish H, Wolfgang, Christopher L, Schulick, Richard D, Choti, Michael A, Kamel, Ihab, Pawlik, Timothy M

“…Abstract Background As indications for liver resection expand, objective measures to assess the risk of peri-operative morbidity are needed. The impact of…”
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Multi-Phenotypic subtyping of circulating tumor cells using sequential fluorescent quenching and restaining by Adams, Daniel L, Alpaugh, R. Katherine, Tsai, Susan, Tang, Cha-Mei, Stefansson, Steingrimur

“…In tissue biopsies formalin fixed paraffin embedded cancer blocks are micro-sectioned producing multiple semi-identical specimens which are analyzed and…”
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