PAX genes in development and disease: the role of PAX2 in urogenital tract development

PAX genes play an important role in fetal development. Moreover, heterozygous mutations in several PAX genes cause human disease. Here we review the role of PAX2 in kidney development, focusing on the morphological effects of PAX2 mutations. We discuss the role of PAX2 in the context of an inhibitor...

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Bibliographic Details
Published in:	The International journal of developmental biology Vol. 46; no. 4; pp. 535 - 544
Main Authors:	Eccles, Michael R, He, Shujie, Legge, Michael, Kumar, Rajiv, Fox, Jody, Zhou, Chaoming, French, Michelle, Tsai, Robert W S
Format:	Journal Article
Language:	English
Published:	Spain 2002
Subjects:	Animals Apoptosis Coloboma - complications DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - physiology Female Gene Expression Regulation, Developmental Heterozygote Homozygote Humans Immunohistochemistry Kidney - abnormalities Kidney - embryology Kidney - metabolism Male Mice Microscopy, Fluorescence Models, Biological Models, Genetic Mutation Oligonucleotide Array Sequence Analysis Oviducts - metabolism PAX2 Transcription Factor Syndrome Transcription Factors - biosynthesis Transcription Factors - physiology Urogenital System - embryology
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Summary:	PAX genes play an important role in fetal development. Moreover, heterozygous mutations in several PAX genes cause human disease. Here we review the role of PAX2 in kidney development, focusing on the morphological effects of PAX2 mutations. We discuss the role of PAX2 in the context of an inhibitory field model of kidney branching morphogenesis and summarize recent progress in this area.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0214-6282