Search Results - "Tsai, Richard M"

Therapy and clinical trials in frontotemporal dementia: past, present, and future by Tsai, Richard M., Boxer, Adam L.

“…Frontotemporal dementia (FTD) is a common form of dementia with heterogeneous clinical presentations and distinct clinical syndromes. This article will review…”
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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy by Shi, Yang, Yamada, Kaoru, Liddelow, Shane Antony, Smith, Scott T., Zhao, Lingzhi, Luo, Wenjie, Tsai, Richard M., Spina, Salvatore, Grinberg, Lea T., Rojas, Julio C., Gallardo, Gilbert, Wang, Kairuo, Roh, Joseph, Robinson, Grace, Finn, Mary Beth, Jiang, Hong, Sullivan, Patrick M., Baufeld, Caroline, Wood, Michael W., Sutphen, Courtney, McCue, Lena, Xiong, Chengjie, Del-Aguila, Jorge L., Morris, John C., Cruchaga, Carlos, Fagan, Anne M., Miller, Bruce L., Boxer, Adam L., Seeley, William W., Butovsky, Oleg, Barres, Ben A., Paul, Steven M., Holtzman, David M.

“…ApoE4 exacerbates tau pathogenesis, neuroinflammation and tau-mediated neurodegeneration independently of brain amyloid-β pathology, and exerts a ‘toxic’ gain…”
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Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy by Chen, Xu, Li, Yaqiao, Wang, Chao, Tang, Yinyan, Mok, Sue-Ann, Tsai, Richard M, Rojas, Julio C, Karydas, Anna, Miller, Bruce L, Boxer, Adam L, Gestwicki, Jason E, Arkin, Michelle, Cuervo, Ana Maria, Gan, Li

“…The trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in…”
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Plasma neurofilament light chain predicts progression in progressive supranuclear palsy by Rojas, Julio C., Karydas, Anna, Bang, Jee, Tsai, Richard M., Blennow, Kaj, Liman, Victor, Kramer, Joel H., Rosen, Howard, Miller, Bruce L., Zetterberg, Henrik, Boxer, Adam L.

“…Objective Blood‐based biomarkers for neurodegenerative conditions could improve diagnosis and treatment development. Neurofilament light chain (NfL), a marker…”
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Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib studies in healthy subjects and patients by Vissers, Maurits F. J. M., Heuberger, Jules A. A. C., Groeneveld, Geert Jan, Oude Nijhuis, Jerome, De Deyn, Peter Paul, Hadi, Salah, Harris, Jeffrey, Tsai, Richard M., Cruz‐Herranz, Andres, Huang, Fen, Tong, Vincent, Erickson, Rebecca, Zhu, Yuda, Scearce‐Levie, Kimberly, Hsiao‐Nakamoto, Jennifer, Tang, Xinyan, Chang, Megan, Fox, Brian M., Estrada, Anthony A., Pomponio, Robert J., Alonso‐Alonso, Miguel, Zilberstein, Moshe, Atassi, Nazem, Troyer, Matthew D., Ho, Carole

“…RIPK1 is a master regulator of inflammatory signaling and cell death and increased RIPK1 activity is observed in human diseases, including Alzheimer’s disease…”
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Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET by La Joie, Renaud, Visani, Adrienne V, Baker, Suzanne L, Brown, Jesse A, Bourakova, Viktoriya, Cha, Jungho, Chaudhary, Kiran, Edwards, Lauren, Iaccarino, Leonardo, Janabi, Mustafa, Lesman-Segev, Orit H, Miller, Zachary A, Perry, David C, O'Neil, James P, Pham, Julie, Rojas, Julio C, Rosen, Howard J, Seeley, William W, Tsai, Richard M, Miller, Bruce L, Jagust, William J, Rabinovici, Gil D

“…β-Amyloid plaques and tau-containing neurofibrillary tangles are the two neuropathological hallmarks of Alzheimer's disease (AD) and are thought to play…”
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18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes by Tsai, Richard M, Bejanin, Alexandre, Lesman-Segev, Orit, LaJoie, Renaud, Visani, Adrienne, Bourakova, Viktoriya, O'Neil, James P, Janabi, Mustafa, Baker, Suzanne, Lee, Suzee E, Perry, David C, Bajorek, Lynn, Karydas, Anna, Spina, Salvatore, Grinberg, Lea T, Seeley, William W, Ramos, Eliana M, Coppola, Giovanni, Gorno-Tempini, Maria Luisa, Miller, Bruce L, Rosen, Howard J, Jagust, William, Boxer, Adam L, Rabinovici, Gil D

“…Background The tau positron emission tomography (PET) ligand .sup.18F-flortaucipir binds to paired helical filaments of tau in aging and Alzheimer's disease…”
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Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial by Tsai, Richard M, Miller, Zachary, Koestler, Mary, Rojas, Julio C, Ljubenkov, Peter A, Rosen, Howard J, Rabinovici, Gil D, Fagan, Anne M, Cobigo, Yann, Brown, Jesse A, Jung, Joo In, Hare, Emma, Geldmacher, David S, Natelson-Love, Marissa, McKinley, Emily C, Luong, Phi N, Chuu, Emmeline L, Powers, Ryan, Mumford, Paige, Wolf, Amy, Wang, Ping, Shamloo, Merhdad, Miller, Bruce L, Roberson, Erik D, Boxer, Adam L

“…Basket-design clinical trials that allow investigation of treatment effects on different clinical syndromes that share the same molecular pathophysiology have…”
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Treatment of Frontotemporal Dementia by Tsai, Richard M., Boxer, Adam L.

“…Opinion statement Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative diseases with heterogeneous clinical presentations and two…”
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CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP by Rojas, Julio C, Bang, Jee, Lobach, Iryna V, Tsai, Richard M, Rabinovici, Gil D, Miller, Bruce L, Boxer, Adam L

“…OBJECTIVETo determine the ability of CSF biomarkers to predict disease progression in progressive supranuclear palsy (PSP). METHODSWe compared the ability of…”
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Clinical trials: past, current, and future for atypical Parkinsonian syndromes by Tsai, Richard M, Boxer, Adam L

“…There are currently no effective Food and Drug Administration-approved treatments for atypical parkinsonian disorders such as progressive supranuclear palsy,…”
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Application of the IWG-2 Diagnostic Criteria for Alzheimer's Disease to the ADNI by Wang, Hui-Fu, Tan, Lan, Cao, Lei, Zhu, Xi-Chen, Jiang, Teng, Tan, Meng-Shan, Liu, Ying, Wang, Chong, Tsai, Richard M, Jia, Jian-Ping, Yu, Jin-Tai

“…The International Working Group (IWG) recently proposed the revised diagnostic criteria for Alzheimer's disease (AD) to define and refine several types of AD,…”
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Clinical correlates of longitudinal brain atrophy in progressive supranuclear palsy by Tsai, Richard M, Lobach, Iryna, Bang, Jee, Whitwell, Jennifer L, Senjem, Matthew L, Jack, Clifford R, Rosen, Howard, Miller, Bruce, Boxer, Adam L

“…Abstract Introduction There are no effective treatments for progressive supranuclear palsy (PSP). Volumetric MRI (vMRI) may be a useful surrogate outcome…”
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The Chinese Verbal Learning Test Specifically Assesses Hippocampal State by Tsai, Richard M., Leong, Josiah K., Dutt, Shubir, Chang, Chiung Chih, Lee, Allen K., Chao, Steven Z., Yokoyama, Jennifer S., Tse, Marian, Kramer, Joel H., Miller, Bruce L., Rosen, Howard J.

“…Background: Recently, the Chinese Verbal Learning Test (ChVLT) was developed to assess episodic memory in Chinese speakers. The goal of this analysis was to…”
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18 F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes by Tsai, Richard M, Bejanin, Alexandre, Lesman-Segev, Orit, LaJoie, Renaud, Visani, Adrienne, Bourakova, Viktoriya, O'Neil, James P, Janabi, Mustafa, Baker, Suzanne, Lee, Suzee E, Perry, David C, Bajorek, Lynn, Karydas, Anna, Spina, Salvatore, Grinberg, Lea T, Seeley, William W, Ramos, Eliana M, Coppola, Giovanni, Gorno-Tempini, Maria Luisa, Miller, Bruce L, Rosen, Howard J, Jagust, William, Boxer, Adam L, Rabinovici, Gil D

“…The tau positron emission tomography (PET) ligand F-flortaucipir binds to paired helical filaments of tau in aging and Alzheimer's disease (AD), but its…”
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Editors by Sahani, Dushyant V., MD, Samir, Anthony E., MD, MPH, Grajo, Joseph R., MD, Horst, Nicole D., MD, MEng, Chen, Luzeng, MD, Dhyani, Manish, MBBS, Kilcoyne, Aoife, MB BCh BAO, B Med Sc, MRCP(UK), FFR(RCSI)MB, BCh, MAO, McCarthy, Colin J., MB, BAO, BCh, MRCSI, FFR(RCSI), Price, Melissa, MD, Sewatkar, Rani S., MD, Thomas, Abraham C., MD, Agnello, Francesco, MD, Aguirre, Diego A., MD, Aher, Pritish, MBBS, DMRD, Anderson, Stephan W., MD, Banerjee, Arpan K., MBBS (LOND), FRCP, FRCR, FBIR, Blake, Michael, MB, BCh, BSc, MRCPI, FRCR, FFR (RCSI), Cantisani, Vito, MD, PhD, Carbognin, Giovanni, MD, Catalano, Onofrio, MD, Chew, Michael, MBBS, BA, Colen, Rivka R., MD, D'Ambrosio, Ugo, MD, D'Onofrio, Mirko, MD, Dachman, Abraham H., MD, FACR, Desai, Hemali, MD, Faria, Silvana C., MD, PhD, Flores, Efrén J., MD, Frank, Mark, MD, Ganesan, Karthik, DNB, Garg, Alpa G., MD, Ghosh, Sukanya, MBBS, MRCP, FRCR, Granja, Manuel F., MD, Graziani, Rossella, MD, Hanna, Robert, MD, Hawes, Donald, MD, Holalkere, Nagaraj-Setty, MD, DNB, Jambhekar, Kedar, MD, DNB, Jankharia, Bijal, MBBS, DMRE, DMRD, DNB, Kalva, Sanjeeva P., MD, MB, BS, Kambadakone, Avinash, MBBS, MD, DNB, FRCR, Kesavarapu, Keerthana, BS, Kim, Hansol, MD, Kim, Kyoung Won, MD, PhD, Kim, Min Ju, MD, Kulkarni, Kirti, MD, Kurup, A. Nick, MD, Lall, Chandana G., MD, Lee, Leslie K., BSc, MD, Lenhart, Dipti K., MD, Liu, Bob, PhD, Ma, Xiaozhou, MD, Macari, Michael, MD, Marcantonio, Andrea, MD, Masrani, Deepa, MD, Mazhar, Sameer M., MD, Mittal, Pardeep, MD, Moore, Michael, MB, BCh, FFR (RCSI), Morana, Giovanni, MD, Motton, Massimiliano, MD, Narin, Ozden, MD, Narra, Vamsidhar R., MD, MBA, FRCR, FACR, Oto, Aytekin, MD, Pandey, Tarun, MD, DNB, FRCR, Panek, Ralph C., MD, Perini, Rodolfo F., MD, Peterson, Michael R., MD, PhD, Petralia, Giuseppe, MD, Power, Niall, MRCPI, FRCR, Prabhakar, Anand M., MD, Prabhakar, Hima B., MD, Prabhakar, Priya D., MD, MPH, Prasad, Srinivasa R., MD, Pryma, Daniel A., MD, Rajesh, Arumugam, MBBS, FRCR, Rebello, Anuradha S., MBBS, Rivero, Oscar M., MD, Roedl, Johannes B., MD, Rosman, David A., MD, MBA, Sanyal, Rupan, MD, Saunders, Alissa, MD, Scuderi, Richard T., MD, PhD, Seale, Melanie, MBBS, FRANZCR, Sebastian, Sunit, MD, Shah, Hemendra, MD, FACR, Shah, Zarine K., MD, MBBS, Shiehmorteza, Masoud, MD, Sirlin, Claude B., MD, Small, William, MD, PhD, Soto, Jorge A., MD, Stein, Lance L., MD, Surabhi, Venkateswar R., MD, Thomas, Stephen, MD, Tsai, Richard, MD, Udeshi, Michelle, MD, Uppot, Raul N., MD, Vaidya, Sujit, MD, Viswamitra, Sanjaya, MD, Walker, T. Gregory, MD, Yokoo, Takeshi, MD, PhD

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