Search Results - "Tsai, Hsing‐Ju"

Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids[S] by Morisseau, Christophe, Inceoglu, Bora, Schmelzer, Kara, Tsai, Hsing-Ju, Jinks, Steven L., Hegedus, Christine M., Hammock, Bruce D.

“…Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely accepted but the mechanism(s) by which these fatty acids act remains…”
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Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance by Luria, Ayala, Bettaieb, Ahmed, Xi, Yannan, Shieh, Guang-Jong, Liu, Hsin-Chen, Inoue, Hiromi, Tsai, Hsing-Ju, Imig, John D, Haj, Fawaz G, Hammock, Bruce D

“…Visceral obesity has been defined as an important element of the metabolic syndrome and contributes to the development of insulin resistance and cardiovascular…”
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Soluble epoxide hydrolase: a novel therapeutic target in stroke by Zhang, Wenri, Koerner, Ines P, Noppens, Ruediger, Grafe, Marjorie, Tsai, Hsing-Ju, Morisseau, Christophe, Luria, Ayala, Hammock, Bruce D, Falck, John R, Alkayed, Nabil J

“…The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are produced in brain and perform important biological functions, including protection from ischemic…”
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Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation by Liu, Jun‐Yan, Tsai, Hsing‐Ju, Hwang, Sung Hee, Jones, Paul D, Morisseau, Christophe, Hammock, Bruce D

“…Background and purpose:  Early soluble epoxide hydrolase inhibitors (sEHIs) such as 12‐(3‐adamantan‐1‐yl‐ureido)‐dodecanoic acid (AUDA) are effective…”
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Prevention and Reversal of Cardiac Hypertrophy by Soluble Epoxide Hydrolase Inhibitors by Xu, Danyan, Li, Ning, He, Yuxia, Timofeyev, Valeriy, Lu, Ling, Tsai, Hsing-Ju, Kim, In-Hae, Tuteja, Dipika, Mateo, Robertino Karlo P., Singapuri, Anil, Davis, Benjamin B., Low, Reginald, Hammock, Bruce D., Chiamvimonvat, Nipavan

“…Sustained cardiac hypertrophy represents one of the most common causes leading to cardiac failure. There is emerging evidence to implicate the involvement of…”
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Soluble Epoxide Hydrolase Inhibitors Reduce the Development of Atherosclerosis in Apolipoprotein E-Knockout Mouse Model by Ulu, Arzu, Davis, Benjamin B, Tsai, Hsing-Ju, Kim, In-Hae, Morisseau, Christophe, Inceoglu, Bora, Fiehn, Oliver, Hammock, Bruce D, Weiss, Robert H

“…To determine whether sEH inhibitors influence atherosclerotic lesion formation, we used an established murine model of accelerated atherogenesis, ApoE knockout…”
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Immunoassay for Monitoring Environmental and Human Exposure to the Polybrominated Diphenyl Ether BDE-47 by Ahn, Ki Chang, Gee, Shirley J, Tsai, Hsing-Ju, Bennett, Deborah, Nishioka, Marcia G, Blum, Arlene, Fishman, Elana, Hammock, Bruce D

“…We developed a selective competitive enzyme-linked immunosorbent assay (ELISA) to monitor environmental and human exposure to polybrominated diphenyl ether…”
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Opposite Regulation of Cholesterol Levels by the Phosphatase and Hydrolase Domains of Soluble Epoxide Hydrolase by EnayetAllah, Ahmed E., Luria, Ayala, Luo, Beibei, Tsai, Hsing-Ju, Sura, Priyanka, Hammock, Bruce D., Grant, David F.

“…Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with two catalytic domains: a C-terminal epoxide hydrolase domain and an N-terminal phosphatase…”
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Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren‐2 transgenic rats with inducible hypertension by Honetschlägerová, Zuzana, Husková, Zuzana, Vaňourková, Zdeňka, Sporková, Alexandra, Kramer, Herbert J., Hwang, Sung Hee, Tsai, Hsing‐Ju, Hammock, Bruce D., Imig, John D., Červenka, Luděk, Kopkan, Libor

“…Non‐technical summary Arachidonic acid metabolites called epoxyeicosatrienoic acids (EETs) influence vascular tone and renal tubular sodium and water transport…”
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Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase by Luria, Ayala, Morisseau, Christophe, Tsai, Hsing-Ju, Yang, Jun, Inceoglu, Bora, De Taeye, Bart, Watkins, Steven M, Wiest, Michelle M, German, J Bruce, Hammock, Bruce D

“…Soluble epoxide hydrolase (Ephx2, sEH) is a bifunctional enzyme with COOH-terminal hydrolase and NH(2)-terminal phosphatase activities. sEH converts…”
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Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase by Kim, In-Hae, Nishi, Kosuke, Kasagami, Takeo, Morisseau, Christophe, Liu, Jun-Yan, Tsai, Hsing-Ju, Hammock, Bruce D.

“…Substituted ureas with a carboxylic acid ester as a secondary pharmacophore are potent soluble epoxide hydrolase (sEH) inhibitors. Although the ester…”
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The Soluble Epoxide Hydrolase as a Pharmaceutical Target for Hypertension by Chiamvimonvat, Nipavan, Ho, Chin-Min, Tsai, Hsing-Ju, Hammock, Bruce D

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Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation by Fife, Kimberly L, Liu, Yingmei, Schmelzer, Kara R, Tsai, Hsing-Ju, Kim, In-Hae, Morisseau, Christophe, Hammock, Bruce D, Kroetz, Deanna L

“…Epoxyeicosatrienoic acids (EETs) are derived from cytochrome P450-catalyzed epoxygenation of arachidonic acid and have emerged as important mediators of…”
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Orally Bioavailable Potent Soluble Epoxide Hydrolase Inhibitors by Hwang, Sung Hee, Tsai, Hsing-Ju, Liu, Jun-Yan, Morisseau, Christophe, Hammock, Bruce D

“…A series of N,N‘-disubstituted ureas having a conformationally restricted cis- or trans-1,4-cyclohexane α to the urea were prepared and tested as soluble…”
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immunoassay for a urinary metabolite as a biomarker of human exposure to the pyrethroid insecticide permethrin by Ahn, Ki Chang, Ma, Seung-Jin, Tsai, Hsing-Ju, Gee, Shirley J, Hammock, Bruce D

“…Permethrin is the most popular synthetic pyrethroid insecticide used in agriculture and public health. For the assessment of human exposure to permethrin, a…”
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Continuous low-level aquatic monitoring (CLAM) samplers for pesticide contaminant screening in urban runoff: Analytical approach and a field test case by Ensminger, Michael P., Vasquez, Martice, Tsai, Hsing-Ju, Mohammed, Sarah, Van Scoy, A., Goodell, Korena, Cho, Gail, Goh, Kean S.

“…Monitoring of surface waters for organic contaminants is costly. Grab water sampling often results in non-detects for organic contaminants due to missing a…”
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Soluble Epoxide Inhibition Is Protective Against Cerebral Ischemia via Vascular and Neural Protection by Simpkins, Alexis N, Rudic, R. Daniel, Schreihofer, Derek A, Roy, Sid, Manhiani, Marlina, Tsai, Hsing-Ju, Hammock, Bruce D, Imig, John D

“…Inhibition of soluble epoxide hydrolase (SEH), the enzyme responsible for degradation of vasoactive epoxides, protects against cerebral ischemia in rats…”
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In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors by Liu, Jun-Yan, Tsai, Hsing-Ju, Morisseau, Christophe, Lango, Jozsef, Hwang, Sung Hee, Watanabe, Takaho, Kim, In-Hae, Hammock, Bruce D.

“…[Display omitted] N,N′-disubstituted urea-based soluble epoxide hydrolase (sEH) inhibitors are promising therapeutics for hypertension, inflammation, and pain…”
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Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs by Tsai, Hsing-Ju, Hwang, Sung Hee, Morisseau, Christophe, Yang, Jun, Jones, Paul D., Kasagami, Takeo, Kim, In-Hae, Hammock, Bruce D.

“…Epoxyeicosatrienoic acids that have anti-hypertensive and anti-inflammatory properties are mainly metabolized by soluble epoxide hydrolase (sEH, EC 3.3.2.3)…”
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1,3-Disubstituted Ureas Functionalized with Ether Groups are Potent Inhibitors of the Soluble Epoxide Hydrolase with Improved Pharmacokinetic Properties by Kim, In-Hae, Tsai, Hsing-Ju, Nishi, Kosuke, Kasagami, Takeo, Morisseau, Christophe, Hammock, Bruce D

“…Soluble epoxide hydrolase (sEH) is a therapeutic target for treating hypertension and inflammation. 1,3-Disubstituted ureas functionalized with an ether group…”
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