Search Results - "Tsai, Hilda"

Endoglin-targeted cancer therapy by Seon, Ben K, Haba, Akinao, Matsuno, Fumihiko, Takahashi, Norihiko, Tsujie, Masanori, She, Xinwei, Harada, Naoko, Uneda, Shima, Tsujie, Tomoko, Toi, Hirofumi, Tsai, Hilda, Haruta, Yuro

“…Vascular-targeting antiangiogenic therapy (VTAT) of cancer can be advantageous over conventional tumor cell targeted cancer therapy if an appropriate target is…”
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Anti‐endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature by Uneda, Shima, Toi, Hirofumi, Tsujie, Tomoko, Tsujie, Masanori, Harada, Naoko, Tsai, Hilda, Seon, Ben K.

“…Anti‐metastatic activity of an antitumor agent is exceedingly important because metastasis is the primary cause of death for most solid cancer patients. In…”
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Induction of Lasting Complete Regression of Preformed Distinct Solid Tumors by Targeting the Tumor Vasculature Using Two New Anti-Endoglin Monoclonal Antibodies by MATSUNO, F, HARUTA, Y, KONDO, M, TSAI, H, BARCOS, M, SEON, B. K

“…Endoglin (EDG, CD105) is a proliferation-associated antigen on endothelial cells. In this study, two new anti-EDG monoclonal antibodies (mAbs) Y4-2F1 (or…”
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Angiogenesis and metastasis marker of human tumors by Seon, B K, Takahashi, N, Haba, A, Matsuno, F, Haruta, Y, She, X W, Harada, N, Tsai, H

“…Tumor growth and metastasis are dependent on angiogenesis. Therefore, certain angiogenesis markers may be useful as metastasis markers and/or the targets for…”
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Anti‐tumor activity of an anti‐endoglin monoclonal antibody is enhanced in immunocompetent mice by Tsujie, Masanori, Tsujie, Tomoko, Toi, Hirofumi, Uneda, Shima, Shiozaki, Ken, Tsai, Hilda, Seon, Ben K.

“…In the present study, we investigated the mechanisms by which anti‐endoglin (EDG; CD105) monoclonal antibodies (mAbs) suppress angiogenesis and tumor growth…”
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Effective anti-angiogenic therapy of established tumors in mice by naked anti-human endoglin (CD105) antibody : Differences in growth rate and therapeutic response between tumors growing at different sites by TSUJIE, Masanori, UNEDA, Shima, TSAI, Hilda, SEON, Ben K

“…We investigated anti-angiogenic/vascular targeting therapy of established tumors in immunocompetent mice using an anti-human endoglin (EDG; CD105) monoclonal…”
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Abstract 3278: Novel knock-in mice expressing human/mouse chimeric endoglin (ENG; CD105) develop normally and will be valuable for evaluating clinical application of anti-human ENG antibodies by Toi, Hirofumi, Duzen, Jill, Fujita, Kanako, Tsujie, Masanori, Tsai, Hilda, Seon, Ben K.

“…Abstract The major objective of this study is to develop a novel animal model to facilitate optimal clinical application of anti-human ENG (huENG) monoclonal…”
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Abstract 378: Serum endoglin (CD105): Molecular heterogeneity and marked differences among different anti-endoglin monoclonal antibodies in the detection of metastasis and tumor progression by Harada, Naoko, Takahashi, Norihiko, Haruta, Yuro, Tsai, Hilda, Greco, William, Seon, Ben K.

“…Abstract Endoglin (ENG, CD105) is a proliferation-associated homodimeric cell membrane antigen of endothelial cells and leukemia cells. It is strongly…”
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Synergy between anti‐endoglin (CD105) monoclonal antibodies and TGF‐β in suppression of growth of human endothelial cells by She, Xinwei, Matsuno, Fumihiko, Harada, Naoko, Tsai, Hilda, Seon, Ben K.

“…Endoglin (CD105) is a proliferation‐associated cell membrane antigen of endothelial cells and strongly expressed in the angiogenic vasculature of solid tumors…”
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Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin by TAKAHASHI, Norihiko, KAWANISHI-TABATA, Rika, HABA, Akinao, TABATA, Masahiro, HARUTA, Yuro, TSAI, Hilda, SEON, Ben K

“…In this report, we present data indicating that the increased serum endoglin (EDG; CD105) quantitated by a double-antibody sandwich assay is associated with…”
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Receptor-targeted anticancer therapy by Seon, Ben K., Haruta, Yuro, Matsuno, Fumihiko, Haba, Akinao, Takahashi, Norihiko, She, Xinwei, Harada, Naoko, Uneda, Shima, Tsujie, Masanori, Tsujie, Tomoko, Toi, Hirofumi, Tsai, Hilda

“…ENG is a homodimeric cell membrane glycoprotein that was initially found on human leukemia cells and subsequently on endothelial cells. ENG as a target for…”
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Antiangiogenic chimeric anti-endoglin (CD105) antibody : pharmacokinetics and immunogenicity in nonhuman primates and effects of doxorubicin by SHIOZAKI, Ken, HARADA, Naoko, GRECO, William R, HABA, Akinao, UNEDA, Shima, TSAI, Hilda, SEON, Ben K

“…We generated a human/mouse chimeric antibody c-SN6j of human IgG1 isotype from a murine anti-human endoglin (EDG) monoclonal antibody (mAb) SN6j that…”
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Association of Serum Endoglin with Metastasis in Patients with Colorectal, Breast, and Other Solid Tumors, and SuppressiveEffect of Chemotherapy on the Serum Endoglin by Norihiko Takahashi, Rika Kawanishi-Tabata, Akinao Haba, Masahiro Tabata, Yuro Haruta, Hilda Tsai, Ben K. Seon

“…In this report, we present data indicating that the increased serum endoglin (EDG; CD105) quantitated by a double-antibody sandwich assay is associated with…”
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Development of a severe combined immunodeficiency (SCID) mouse model consisting of highly disseminated human B-cell leukemia/lymphoma, cure of the tumors by systemic administration of immunotoxin, and development/application of a clonotype-specific polymerase chain reaction-based assay by YOSHIDA, M, RYBAK, R. J, CHOI, Y, GREENBERG, S. J, BARCOS, M, KAWATA, A, MATSUNO, F, TSAI, H, SEON, B. K

“…A new severe combined immunodeficiency (SCID) mouse model consisting of highly disseminated human B-cell leukemia/lymphoma was developed by i.v. inoculation of…”
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