Search Results - "Tsai, Albert G."

Terminal deoxynucleotidyl transferase and CD84 identify human multi-potent lymphoid progenitors by Kim, YeEun, Calderon, Ariel A., Favaro, Patricia, Glass, David R., Tsai, Albert G., Ho, Daniel, Borges, Luciene, Greenleaf, William J., Bendall, Sean C.

“…Lymphoid specification in human hematopoietic progenitors is not fully understood. To better associate lymphoid identity with protein-level cell features, we…”
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Mechanisms of chromosomal rearrangement in the human genome by Tsai, Albert G, Lieber, Michael R

“…Many human cancers are associated with characteristic chromosomal rearrangements, especially hematopoietic cancers such as leukemias and lymphomas. The first…”
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H3K4me3 Stimulates the V(D)J RAG Complex for Both Nicking and Hairpinning in trans in Addition to Tethering in cis: Implications for Translocations by Shimazaki, Noriko, Tsai, Albert G., Lieber, Michael R.

“…The PHD finger of the RAG2 polypeptide of the RAG1/RAG2 complex binds to the histone H3 modification, trimethylated lysine 4 (H3K4me3), and in some manner…”
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Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome by Wang, Sa A, Hasserjian, Robert P, Tam, Wayne, Tsai, Albert G, Geyer, Julia T, George, Tracy I, Foucar, Kathryn, Rogers, Heesun J, Hsi, Eric D, Rea, Bryan A, Bagg, Adam, Bueso-Ramos, Carlos E, Arber, Daniel A, Verstovsek, Srdan, Orazi, Attilio

“…Chronic eosinophilic leukemia, not otherwise specified can be difficult to distinguish from idiopathic hypereosinophilic syndrome according to the current…”
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Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence by Gu, Jiafeng, Lu, Haihui, Tsai, Albert G., Schwarz, Klaus, Lieber, Michael R.

“…The double-strand DNA break repair pathway, non-homologous DNA end joining (NHEJ), is distinctive for the flexibility of its nuclease, polymerase and ligase…”
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Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans by Lieber, Michael R, Gu, Jiafeng, Lu, Haihui, Shimazaki, Noriko, Tsai, Albert G

“…Double-strand breaks (DSBs) arise in dividing cells about ten times per cell per day. Causes include replication across a nick, free radicals of oxidative…”
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BCL6 breaks occur at different AID sequence motifs in Ig–BCL6 and non-Ig–BCL6 rearrangements by Lu, Zhengfei, Tsai, Albert G., Akasaka, Takashi, Ohno, Hitoshi, Jiang, Yanwen, Melnick, Ari M., Greisman, Harvey A., Lieber, Michael R.

“…BCL6 translocations are common in B-cell lymphomas and frequently have chromosomal breaks in immunoglobulin heavy chain (IgH) switch regions, suggesting that…”
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Mass Cytometry Phenotyping of Human Granulocytes Reveals Novel Basophil Functional Heterogeneity by Vivanco Gonzalez, Nora, Oliveria, John-Paul, Tebaykin, Dmitry, Ivison, Geoffrey T., Mukai, Kaori, Tsai, Mindy M., Borges, Luciene, Nadeau, Kari C., Galli, Stephen J., Tsai, Albert G., Bendall, Sean C.

“…Basophils, the rarest granulocyte, play critical roles in parasite- and allergen-induced inflammation. We applied mass cytometry (CyTOF) to simultaneously…”
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Both CpG Methylation and Activation-Induced Deaminase Are Required for the Fragility of the Human bcl-2 Major Breakpoint Region: Implications for the Timing of the Breaks in the t(14;18) Translocation by Cui, Xiaoping, Lu, Zhengfei, Kurosawa, Aya, Klemm, Lars, Bagshaw, Andrew T., Tsai, Albert G., Gemmell, Neil, Müschen, Markus, Adachi, Noritaka, Hsieh, Chih-Lin, Lieber, Michael R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An optimized protocol for phenotyping human granulocytes by mass cytometry by Vivanco Gonzalez, Nora, Oliveria, John-Paul, Tebaykin, Dmitry, Ivison, Geoffrey T., Mukai, Kaori, Tsai, Mindy M., Borges, Luciene, Nadeau, Kari C., Galli, Stephen J., Tsai, Albert G., Bendall, Sean C.

“…Granulocytes encompass diverse roles, from fighting off pathogens to regulating inflammatory processes in allergies. These roles are represented by distinct…”
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An Integrated Multi-omic Single-Cell Atlas of Human B Cell Identity by Glass, David R., Tsai, Albert G., Oliveria, John Paul, Hartmann, Felix J., Kimmey, Samuel C., Calderon, Ariel A., Borges, Luciene, Glass, Marla C., Wagar, Lisa E., Davis, Mark M., Bendall, Sean C.

“…B cells are capable of a wide range of effector functions including antibody secretion, antigen presentation, cytokine production, and generation of…”
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Conformational Variants of Duplex DNA Correlated with Cytosine-rich Chromosomal Fragile Sites by Tsai, Albert G., Engelhart, Aaron E., Hatmal, Ma'mon M., Houston, Sabrina I., Hud, Nicholas V., Haworth, Ian S., Lieber, Michael R.

“…We found that several major chromosomal fragile sites in human lymphomas, including the bcl-2 major breakpoint region, bcl-1 major translocation cluster, and…”
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Multiplexed single-cell morphometry for hematopathology diagnostics by Tsai, Albert G., Glass, David R., Juntilla, Marisa, Hartmann, Felix J., Oak, Jean S., Fernandez-Pol, Sebastian, Ohgami, Robert S., Bendall, Sean C.

“…The diagnosis of lymphomas and leukemias requires hematopathologists to integrate microscopically visible cellular morphology with antibody-identified cell…”
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Targeted next-generation sequencing identifies a subset of idiopathic hypereosinophilic syndrome with features similar to chronic eosinophilic leukemia, not otherwise specified by Wang, Sa A, Tam, Wayne, Tsai, Albert G, Arber, Daniel A, Hasserjian, Robert P, Geyer, Julia T, George, Tracy I, Czuchlewski, David R, Foucar, Kathryn, Rogers, Heesun J, Hsi, Eric D, Bryan Rea, B, Bagg, Adam, Dal Cin, Paola, Zhao, Chong, Kelley, Todd W, Verstovsek, Srdan, Bueso-Ramos, Carlos, Orazi, Attilio

“…The distinction between chronic eosinophilic leukemia, not otherwise specified and idiopathic hypereosinophilic syndrome largely relies on clonality…”
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Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells by Tsai, Albert G, Chen, Debbie M, Lin, Mayin, Hsieh, John C F, Okitsu, Cindy Y, Taghva, Alexander, Shibata, Darryl, Hsieh, Chih-Lin

“…DNA methylation has been proposed to be important in many biological processes and is the subject of intense study. Traditional bisulfite genomic sequencing…”
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Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity by Tsai, Albert G., Lu, Haihui, Raghavan, Sathees C., Muschen, Markus, Hsieh, Chih-Lin, Lieber, Michael R.

“…We have assembled, annotated, and analyzed a database of over 1700 breakpoints from the most common chromosomal rearrangements in human leukemias and…”
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IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas by Greisman, Harvey A., Lu, Zhengfei, Tsai, Albert G., Greiner, Timothy C., Yi, Hye Son, Lieber, Michael R.

“…Previous studies have implicated activation-induced cytidine deaminase (AID) in B-cell translocations but have failed to identify any association between their…”
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Supervised dimensionality reduction for exploration of single-cell data by HSS-LDA by Amouzgar, Meelad, Glass, David R., Baskar, Reema, Averbukh, Inna, Kimmey, Samuel C., Tsai, Albert G., Hartmann, Felix J., Bendall, Sean C.

“…Single-cell technologies generate large, high-dimensional datasets encompassing a diversity of omics. Dimensionality reduction captures the structure and…”
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The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not by Tsai, Albert G., Lu, Zhengfei, Lieber, Michael R.

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Human Lymphoid Translocation Fragile Zones Are Hypomethylated and Have Accessible Chromatin by Lu, Zhengfei, Lieber, Michael R., Tsai, Albert G., Pardo, Carolina E., Müschen, Markus, Kladde, Michael P., Hsieh, Chih-Lin

“…Chromosomal translocations are a hallmark of hematopoietic malignancies. CG motifs within translocation fragile zones (typically 20 to 600 bp in size) are…”
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