Search Results - "Tryggestad, Jeanie"

188-LB: MicroRNA-126-3p Impacts Insulin Signaling in Smooth Muscle Cells by TRYGGESTAD, JEANIE B.

“…Human umbilical vein endothelial cells (HUVEC) are a rich source of miRNA-126-3p. HUVEC package miR-126-3p into exosomes and secrete them into the…”
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272-OR: Impact of Maternal Diabetes on MicroRNA Expression in Fetal Tissue by RUGHANI, ANKUR, TRYGGESTAD, JEANIE B.

“…In utero diabetes (DM) exposure alters offspring metabolic memory and increases future cardiovascular risk (CVD) risk. MicroRNAs (miR), small noncoding RNAs…”
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Polygenic risk for obesity and body dissatisfaction: beyond BMI by Jeter, Kathryn M, Srinivasan, Shylaja, Tryggestad, Jeanie B

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Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA by Tryggestad, Jeanie B, Vishwanath, Anu, Jiang, Shaoning, Mallappa, Ashwini, Teague, April M, Takahashi, Yusuke, Thompson, David M, Chernausek, Steven D

“…We aimed to identify miRNAs whose expression levels in fetal tissues are altered by exposure to a diabetic milieu and elucidate the impact on target protein…”
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Type 2 Diabetes in Youth: the Role of Early Life Exposures by Rughani, Ankur, Friedman, Jacob E., Tryggestad, Jeanie B.

“…Purpose of Review This review examines the impact of early life exposures on glucose metabolism in the offspring and explores potential metabolic mechanisms…”
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AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells by Wu, Jianbo, Gulati, Shelly, Teague, April M, Kim, Youngsil, Tryggestad, Jeanie B, Jiang, Shaoning

“…Adverse intrauterine environments can cause persistent changes in epigenetic profiles of stem cells, increasing susceptibility of the offspring to developing…”
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159-LB: Circulating MicroRNAs as Predictors of ß-Cell Function in Youth Onset Type 2 Diabetes—The TODAY Study by TRYGGESTAD, JEANIE B., BIALEK, SHANNAN, REDLING, DAKOTA, CHERNAUSEK, STEVEN, EL GHORMLI, LAURE

“…In the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study, half the participants reached the primary outcome (HbA1c≥8% for at least 6…”
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160-LB: Circulating MicroRNAs as Predictors of Microvascular Complications in Youth Onset Type 2 Diabetes—The TODAY Study by REDLING, DAKOTA, BIALEK, SHANNAN, CHERNAUSEK, STEVEN, EL GHORMLI, LAURE, TRYGGESTAD, JEANIE B.

“…From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study, 60% of the participants demonstrated diabetes-related complications by…”
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Maternal diabetes alters microRNA expression in fetal exosomes, human umbilical vein endothelial cells and placenta by Shah, Kruti B., Chernausek, Steven D., Teague, April M., Bard, David E., Tryggestad, Jeanie B.

“…Background Exposure to diabetes in utero influences future metabolic health of the offspring. MicroRNAs (miRNA) are small noncoding RNAs that may contribute…”
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Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway by Jiang, Shaoning, Teague, April M., Tryggestad, Jeanie B., Chernausek, Steven D.

“…Diabetes during pregnancy is associated with abnormal placenta mitochondrial function and increased oxidative stress, which affect fetal development and…”
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Circulating MicroRNAs as Predictors of Beta Cell Function in Youth-onset Type 2 Diabetes: The TODAY Study by Redling, Dakota, Bialak, Shannon, El ghormli, Laure, Chernausek, Steven D, Jones, Kenneth, Tryggestad, Jeanie B

“…Abstract Aims In the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study, an intervention trial followed by an observational phase,…”
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Macrophage‐Derived microRNA‐155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator‐Activated Receptor Gamma by Tryggestad, Jeanie B., Teague, April M., Sparling, David P., Jiang, Shaoning, Chernausek, Steven D.

“…Objective This study aimed to investigate cellular sources of microRNAs (miRNA) within adipose tissue and the impact of obesity on miRNA expression, as well as…”
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Heart Rate Variability and Cardiac Autonomic Dysfunction: Prevalence, Risk Factors and Relationship to Arterial Stiffness in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study by Shah, Amy S, El Ghormli, Laure, Vajravelu, Mary Ellen, Bacha, Fida, Farrell, Ryan M, Gidding, Samuel S, Levitt Katz, Lorraine E, Tryggestad, Jeanie B, White, Neil H, Urbina, Elaine M

“…To determine whether prior type 2 diabetes (T2D) treatment or glycemic control over time are independently associated with heart rate variability (HRV) and…”
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Complications and comorbidities of T2DM in adolescents: findings from the TODAY clinical trial by Tryggestad, Jeanie B, Willi, Steven M

“…Abstract With the rise in childhood obesity, type 2 diabetes mellitus (T2DM) has been recognized to occur in adolescents with increasing frequency. Although…”
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1180-P: Impact of Diabetes Exposure In Utero on Mesenchymal Stem Cell Phenotype and Metabolic Function by HAN LEE, WAI, REDLING, DAKOTA, BROOKS, OLIVIA, TEAGUE, APRIL M., JIANG, SHAONING, TRYGGESTAD, JEANIE B.

“…Fetal programming events at the level of the MSC not only direct development of fetal tissues in utero but may also impact these tissues throughout the life…”
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Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes by Jiang, Shaoning, Teague, April M., Tryggestad, Jeanie B., Jensen, Mary E., Chernausek, Steven D.

“…Adverse maternal environments, such as diabetes and obesity, impair placental mitochondrial function, which affects fetal development and offspring long-term…”
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BMI changes through childhood: the impact on puberty, linear growth and hormonal regulation by Tryggestad, Jeanie B., Chernausek, Steven D.

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96-OR: Adverse Micro- and Macrovascular Outcomes in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH and TODAY Studies by MOTTL, AMY K., ISOM, SCOTT, TRYGGESTAD, JEANIE B., GUBITOSI-KLUG, ROSE, DOLAN, LAWRENCE M., DAGOSTINO, RALPH, DREWS, KIMBERLY

“…We sought to determine incidence rates for micro- and macrovascular events in youth-onset type 1 (T1D) and type 2 (T2D) diabetes in the SEARCH (T1D: N=564;…”
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Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis by Jiang, Shaoning, Teague, April M, Tryggestad, Jeanie B, Lyons, Timothy J, Chernausek, Steven D

“…Diabetes during pregnancy affects placental mitochondrial content and function, which has the potential to impact fetal development and the long-term health of…”
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The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes by Magge, Sheela N., Wolf, Risa M., Pyle, Laura, Brown, Elizabeth A., Benavides, Valeria C., Bianco, Monica E., Chao, Lily C., Cymbaluk, Anna, Balikcioglu, Pinar Gumus, Halpin, Kelsee, Hsia, Daniel S., Huerta-Saenz, Lina, Kim, Jane J., Kumar, Seema, Levitt Katz, Lorraine E., Marks, Brynn E., Neyman, Anna, O'Sullivan, Katie L., Pillai, Sabitha Sasidharan, Shah, Amy S., Shoemaker, Ashley H., Siddiqui, Juwairriyyah A.W., Srinivasan, Shylaja, Thomas, Inas H., Tryggestad, Jeanie B., Yousif, Maha F., Kelsey, Megan M.

“…To evaluate the frequency and severity of new cases of youth-onset type 2 diabetes in the US during the first year of the pandemic compared with the mean of…”
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