Chronic eosinophilic leukemia presenting with autoimmune hemolytic anemia and erythrophagocytosis by eosinophils

Eosinophils function primarily as secretory cells and phagocytosis by eosinophils is rarely seen. We describe a case of chronic eosinophilic leukemia (CEL) in a 72‐year‐old male with a history of previously treated non‐Hodgkin's lymphoma (NHL) presenting with erythrophagocytosis by eosinophils...

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Bibliographic Details
Published in:	American journal of hematology Vol. 81; no. 6; pp. 458 - 461
Main Authors:	Kuk, J.S., MacEachern, J.A., Soamboonsrup, P., McFarlane, A., Benger, A., Patterson, W., Yang, L., Trus, M.R.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-06-2006 Wiley-Liss
Subjects:	Aged anemia Anemia, Hemolytic, Autoimmune - blood Anemia, Hemolytic, Autoimmune - complications Anemia, Hemolytic, Autoimmune - pathology Anemias. Hemoglobinopathies Biological and medical sciences Bone Marrow - pathology Diseases of red blood cells Eosinophils - pathology Erythrocytes - pathology erythrophagocytosis Glycoproteins - metabolism Hematologic and hematopoietic diseases hemolytic Humans hypereosinophilia Hypereosinophilic Syndrome - blood Hypereosinophilic Syndrome - complications Hypereosinophilic Syndrome - pathology leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Count Lymphoma, Non-Hodgkin - blood Lymphoma, Non-Hodgkin - pathology Lysophospholipase - metabolism Male Medical sciences Myelopoiesis Neoplasms, Second Primary - blood Neoplasms, Second Primary - complications Neoplasms, Second Primary - pathology Phagocytosis Autoimmunity Immunopathology leukemia Eosinophilic leukemia Hematology Granulocyte Malignant hemopathy Eosinophil Erythrophagocytosis anemia Myeloproliferative syndrome Chronic Hemolytic anemia Autoimmune hemolytic anemia hypereosinophilia hemolytic
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Summary:	Eosinophils function primarily as secretory cells and phagocytosis by eosinophils is rarely seen. We describe a case of chronic eosinophilic leukemia (CEL) in a 72‐year‐old male with a history of previously treated non‐Hodgkin's lymphoma (NHL) presenting with erythrophagocytosis by eosinophils and an associated autoimmune hemolytic anemia (AIHA). This patient did not show evidence of relapsed NHL. The patient's blood showed a markedly elevated eosinophil count of 16 × 109/L [normal 0–0.45 × 109/L] on a background of myelodysplasia and features of AIHA. Prominent erythrophagocytosis by eosinophils was visualized in the blood and in the bone marrow. Numerous Charcot–Leyden crystals were also seen in the bone marrow amid increased numbers of eosinophils and the presence of dysplastic granulopoiesis. AIHA is rarely described in the setting of CEL. More significantly, this represents the first case report to describe erythrophagocytosis by eosinophils. Am. J. Hematol. 81:458–461, 2006. © 2006 Wiley‐Liss, Inc.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.20601