Search Results - "Truong, Tin T"

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex by Liang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G. B., Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T., Thal, David M., Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M., Wootten, Denise

“…The structure of the glucagon-like peptide 1 receptor (GLP-1R) with its biased agonist exendin-P5 sheds light on both receptor activation and the mechanism of…”
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Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists by Zhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M., Wootten, Denise

“…Peptide drugs targeting class B1 G-protein-coupled receptors (GPCRs) can treat multiple diseases; however, there remains substantial interest in the…”
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Activation of the GLP-1 receptor by a non-peptidic agonist by Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M., Wootten, Denise

“…Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, including diabetes and obesity 1 . Structures of active receptors…”
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Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation by Liang, Yi-Lynn, Belousoff, Matthew J., Zhao, Peishen, Koole, Cassandra, Fletcher, Madeleine M., Truong, Tin T., Julita, Villy, Christopoulos, George, Xu, H. Eric, Zhang, Yan, Khoshouei, Maryam, Christopoulos, Arthur, Danev, Radostin, Sexton, Patrick M., Wootten, Denise

“…Class B G protein-coupled receptors (GPCRs) are important therapeutic targets for major diseases. Here, we present structures of peptide and Gs-bound pituitary…”
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Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation by Deganutti, Giuseppe, Liang, Yi-Lynn, Zhang, Xin, Khoshouei, Maryam, Clydesdale, Lachlan, Belousoff, Matthew J., Venugopal, Hari, Truong, Tin T., Glukhova, Alisa, Keller, Andrew N., Gregory, Karen J., Leach, Katie, Christopoulos, Arthur, Danev, Radostin, Reynolds, Christopher A., Zhao, Peishen, Sexton, Patrick M., Wootten, Denise

“…The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic disorders. Despite recent…”
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Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR‑G Protein Complexes for Structure Determination by Liang, Yi-Lynn, Zhao, Peishen, Draper-Joyce, Christopher, Baltos, Jo-Anne, Glukhova, Alisa, Truong, Tin T, May, Lauren T, Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M, Furness, Sebastian G. B

“…Advances in structural biology have yielded exponential growth in G protein-coupled receptor (GPCR) structure solution. Nonetheless, the instability of fully…”
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Implications of ligand-receptor binding kinetics on GLP-1R signalling by Zhao, Peishen, Truong, Tin T., Merlin, Jon, Sexton, Patrick M., Wootten, Denise

“…[Display omitted] G protein-coupled receptors (GPCRs) are the largest class of membrane proteins and in recent years there has been a growing appreciation of…”
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Structural and functional diversity among agonist-bound states of the GLP-1 receptor by Cary, Brian P., Deganutti, Giuseppe, Zhao, Peishen, Truong, Tin T., Piper, Sarah J., Liu, Xinyu, Belousoff, Matthew J., Danev, Radostin, Sexton, Patrick M., Wootten, Denise, Gellman, Samuel H.

“…Recent advances in G-protein-coupled receptor (GPCR) structural elucidation have strengthened previous hypotheses that multidimensional signal propagation…”
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AM833 Is a Novel Agonist of Calcitonin Family G Protein-Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists by Fletcher, Madeleine M, Keov, Peter, Truong, Tin T, Mennen, Grace, Hick, Caroline A, Zhao, Peishen, Furness, Sebastian G B, Kruse, Thomas, Clausen, Trine R, Wootten, Denise, Sexton, Patrick M

“…Obesity and associated comorbidities are a major health burden, and novel therapeutics to help treat obesity are urgently needed. There is increasing evidence…”
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O‑GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity by Levine, Paul M, Balana, Aaron T, Sturchler, Emmanuel, Koole, Cassandra, Noda, Hiroshi, Zarzycka, Barbara, Daley, Eileen J, Truong, Tin T, Katritch, Vsevolod, Gardella, Thomas J, Wootten, Denise, Sexton, Patrick M, McDonald, Patricia, Pratt, Matthew R

“…Peptide agonists of GPCRs and other receptors are powerful signaling molecules with high potential as biological tools and therapeutics, but they are typically…”
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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptorGs complex by Liang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G. B, Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T, Thal, David M, Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J, Christopoulos, Arthur, Sexton, Patrick M, Wootten, Denise

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