Search Results - "Truong, Thu H"

Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation by Truong, Thu H, Carroll, Kate S

“…Epidermal growth factor receptor (EGFR) exemplifies the family of receptor tyrosine kinases that mediate numerous cellular processes, including growth,…”
Get full text

Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase by Truong, Thu H, Ung, Peter Man-Un, Palde, Prakash B, Paulsen, Candice E, Schlessinger, Avner, Carroll, Kate S

“…Epidermal growth factor receptor (EGFR) is a target of signal-derived H2O2, and oxidation of active-site cysteine 797 to sulfenic acid enhances kinase…”
Get more information

Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs by Knutson, Todd P, Truong, Thu H, Ma, Shihong, Brady, Nicholas J, Sullivan, Megan E, Raj, Ganesh, Schwertfeger, Kathryn L, Lange, Carol A

“…Estrogen and progesterone are potent breast mitogens. In addition to steroid hormones, multiple signaling pathways input to estrogen receptor (ER) and…”
Get full text

Stress sensing within the breast tumor microenvironment: how glucocorticoid receptors live in the moment by Kerkvliet, Carlos Perez, Truong, Thu H, Ostrander, Julie Hanson, Lange, Carol A

“…The classification and treatment of breast cancer is largely defined by the expression of steroid hormone receptors (HRs), namely estrogen receptor (ER) and…”
Get more information

Deciphering Steroid Receptor Crosstalk in Hormone-Driven Cancers by Truong, Thu H, Lange, Carol A

“…Abstract Steroid hormone receptors (SRs) have a multitude of functions in human biology and disease progression. The SR family of related ligand-activated…”
Get full text

Analytical study of the sth-order perturbative corrections to the solution to a one-dimensional harmonic oscillator perturbed by a spatially power-law potential Vper(x) = λxα by Anh-Tai, Tran Duong, Hoang, Duc T., Truong, Thu D. H., Nguyen, Chinh Dung, Uyen, Le Ngoc, Dung, Do Hung, Vy, Nguyen Duy, Pham, Vinh N. T.

“…In this work, we present a rigorous mathematical scheme for the derivation of the sth-order perturbative corrections to the solution to a one-dimensional…”
Get full text

Redox regulation of protein kinases by Truong, Thu H, Carroll, Kate S

“…Protein kinases represent one of the largest families of genes found in eukaryotes. Kinases mediate distinct cellular processes ranging from proliferation,…”
Get more information

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity by Paulsen, Candice E, Truong, Thu H, Garcia, Francisco J, Homann, Arne, Gupta, Vinayak, Leonard, Stephen E, Carroll, Kate S

“…A sensitive probe that detects protein sulfenylation in cells reveals that sulfenylation of the active site cysteine in EGFR enhances its kinase activity…”
Get full text

90 YEARS OF PROGESTERONE: Steroid receptors as MAPK signaling sensors in breast cancer: let the fates decide by Dwyer, Amy R, Truong, Thu H, Ostrander, Julie H, Lange, Carol A

“…Steroid hormone receptors (SRs) are classically defined as ligand-activated transcription factors that function as master regulators of gene programs important…”
Get full text

Steroid Receptors as MAPK Signaling Sensors in Breast Cancer: Let the Fates Decide by Dwyer, Amy R, Truong, Thu H, Ostrander, Julie H, Lange, Carol A

“…Steroid hormone receptors (SRs) are classically defined as ligand-activated transcription factors that function as master regulators of gene programs important…”
Get full text

Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in oestrogen receptor+ breast cancer by Dwyer, Amy R., Truong, Thu H., Kerkvliet, Carlos Perez, Paul, Kiran V., Kabos, Peter, Sartorius, Carol A., Lange, Carol A.

“…Background Progesterone receptors (PR) are potent modifiers of endocrine responses. In aberrant signalling cancer contexts, phosphorylation events dramatically…”
Get full text

Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates by Truong, Thu H, Dwyer, Amy R, Diep, Caroline H, Hu, Hsiangyu, Hagen, Kyla M, Lange, Carol A

“…Abstract Progesterone receptors (PRs) are key modifiers of estrogen receptor (ER) target genes and drivers of luminal breast cancer progression. Total PR…”
Get full text

Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models by Leehy, Katherine A., Truong, Thu H., Mauro, Laura J., Lange, Carol A.

“…•PR and PRLR signaling cooperate in breast cancer.•PR/PRLR signaling may play a role in modulating mammographic breast density.•PR/PRLR pathways could offer…”
Get full text

Glucocorticoid Receptors Drive Breast Cancer Cell Migration and Metabolic Reprogramming via PDK4 by Dwyer, Amy R, Perez Kerkvliet, Carlos, Truong, Thu H, Hagen, Kyla M, Krutilina, Raisa I, Parke, Deanna N, Oakley, Robert H, Liddle, Christopher, Cidlowski, John A, Seagroves, Tiffany N, Lange, Carol A

“…Abstract Corticosteroids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and are routinely prescribed to breast cancer patients…”
Get full text

Flexible Fluorine-Thiol Displacement Stapled Peptides with Enhanced Membrane Penetration for the Estrogen Receptor/Coactivator Interaction by Maloney, Robert, Junod, Samuel L., Hagen, Kyla M., Lewis, Todd, Cheng, Changfeng, Shajan, Femil J., Zhao, Mi, Moore, Terry W., Truong, Thu H., Yang, Weidong, Wang, Rongsheng E.

“…Understanding how natural and engineered peptides enter cells would facilitate the elucidation of biochemical mechanisms underlying cell biology and is pivotal…”
Get full text

Leveraging Antiprogestins in the Treatment of Metastatic Breast Cancer by Kamaraju, Sailaja, Fowler, Amy M, Weil, Elizabeth, Wisinski, Kari B, Truong, Thu H, Lehr, Martin, Chaudhary, Lubna N, Cheng, Yee Chung, Chitambar, Christopher R, Rui, Hallgeir, Yee, Douglas, Lange, Carol

“…Although incurable, the prognosis for patients with metastatic breast cancer (MBC) has considerably improved with the approvals of multiple targeted and…”
Get full text

PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER+ breast cancer by Truong, Thu H., Benner, Elizabeth A., Hagen, Kyla M., Temiz, Nuri A., Kerkvliet, Carlos Perez, Wang, Ying, Cortes-Sanchez, Emilio, Yang, Chieh-Hsiang, Trousdell, Marygrace C., Pengo, Thomas, Guillen, Katrin P., Welm, Bryan E., Dos Santos, Camila O., Telang, Sucheta, Lange, Carol A., Ostrander, Julie H.

“…Recurrence of metastatic breast cancer stemming from acquired endocrine and chemotherapy resistance remains a health burden for women with luminal (ER + )…”
Get full text

Cancer Stem Cell Phenotypes in ER + Breast Cancer Models Are Promoted by PELP1/AIB1 Complexes by Truong, Thu H, Hu, Hsiangyu, Temiz, Nuri A, Hagen, Kyla M, Girard, Brian J, Brady, Nicholas J, Schwertfeger, Kathryn L, Lange, Carol A, Ostrander, Julie H

“…Proline, glutamic acid, leucine-rich protein 1 (PELP1) is overexpressed in approximately 80% of invasive breast tumors. PELP1 dynamically shuttles between the…”
Get full text

Isotope-coded chemical reporter and acid-cleavable affinity reagents for monitoring protein sulfenic acids by Truong, Thu H., Garcia, Francisco J., Seo, Young Ho, Carroll, Kate S.

“…We have developed an approach that allows relative quantification of protein sulfenic acids using a pair of light and heavy isotope labled probes, DAz-2 and…”
Get full text

Targeting steroid receptor co-activators to inhibit breast cancer stem cells by Truong, Thu H, Lange, Carol A, Ostrander, Julie H

Get full text