Search Results - "Truong, Hau"

Dynamics of MHC-I molecules in the antigen processing and presentation pathway by Truong, Hau V, Sgourakis, Nikolaos G

“…•MHC-I molecules exhibit allotype-dependent conformational flexibility, which is critical for their function.•Peptide-deficient MHC-I adopt distinct groove…”
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Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation by Jiang, Jiansheng, Taylor, Daniel K., Kim, Ellen J., Boyd, Lisa F., Ahmad, Javeed, Mage, Michael G., Truong, Hau V., Woodward, Claire H., Sgourakis, Nikolaos G., Cresswell, Peter, Margulies, David H., Natarajan, Kannan

“…Loading of MHC-I molecules with peptide by the catalytic chaperone tapasin in the peptide loading complex plays a critical role in antigen presentation and…”
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Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes by Sun, Yi, Young, Michael C, Woodward, Claire H, Danon, Julia N, Truong, Hau V, Gupta, Sagar, Winters, Trenton J, Font-Burgada, Joan, Burslem, George M, Sgourakis, Nikolaos G

“…The polymorphic nature and intrinsic instability of class I major histocompatibility complex (MHC-I) and MHC-like molecules loaded with suboptimal peptides,…”
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Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases by Schaub, Andrew J, Moreno, Gabriel O, Zhao, Shiji, Truong, Hau V, Luo, Ray, Tsai, Shiou-Chuan

“…Various computational methodologies can be applied to enzymological studies on enzymes in the fatty acid, polyketide, and non-ribosomal peptide biosynthetic…”
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Repurposing of Nitroxoline Drug for the Prevention of Neurodegeneration by Van Hau, Truong, Ruankham, Waralee, Suwanjang, Wilasinee, Songtawee, Napat, Wongchitrat, Prapimpun, Pingaew, Ratchanok, Prachayasittikul, Virapong, Prachayasittikul, Supaluk, Phopin, Kamonrat

“…Oxidative stress has been documented as one of the significant causes of neurodegenerative diseases. Therefore, antioxidant therapy for the prevention of…”
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Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion by Sun, Yi, Florio, Tyler J, Gupta, Sagar, Young, Michael C, Marshall, Quinlen F, Garfinkle, Samuel E, Papadaki, Georgia F, Truong, Hau V, Mycek, Emily, Li, Peiyao, Farrel, Alvin, Church, Nicole L, Jabar, Shereen, Beasley, Matthew D, Kiefel, Ben R, Yarmarkovich, Mark, Mallik, Leena, Maris, John M, Sgourakis, Nikolaos G

“…Peptide-centric chimeric antigen receptors (PC-CARs) recognize oncoprotein epitopes displayed by cell-surface human leukocyte antigens (HLAs) and offer a…”
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Probing Relative Domain Mobility of Class-I Major Histocompability Complex Molecules through Residual Dipolar Couplings by Truong, Hau V., Sgourakis, Nikolaos

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Universal, open MHC-I for rapid ligand loading and enhanced complex stability across classical and non-classical allotypes by Young, Michael C, Sun, Yi, Woodward, Claire H., Danon, Julia N., Truong, Hau V., Sgourakis, Nikolaos G.

“…Abstract The instability of class I major histocompatibility complex (MHC-I) and MHC-like molecules loaded with suboptimal peptides, metabolites, or…”
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Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs by Yarmarkovich, Mark, Marshall, Quinlen F, Warrington, John M, Premaratne, Rasika, Farrel, Alvin, Groff, David, Li, Wei, di Marco, Moreno, Runbeck, Erin, Truong, Hau, Toor, Jugmohit S, Tripathi, Sarvind, Nguyen, Son, Shen, Helena, Noel, Tiffany, Church, Nicole L, Weiner, Amber, Kendsersky, Nathan, Martinez, Dan, Weisberg, Rebecca, Christie, Molly, Eisenlohr, Laurence, Bosse, Kristopher R, Dimitrov, Dimiter S, Stevanovic, Stefan, Sgourakis, Nikolaos G, Kiefel, Ben R, Maris, John M

“…The majority of oncogenic drivers are intracellular proteins, thus constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented…”
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Mechanistic aspects of tapasin-mediated antigen presentation revealed by structure of a tapasin/MHC-I complex by Natarajan, Kannan, Jiang, Jiansheng, Taylor, Daniel Kyle, Kim, Ellen J, Boyd, Lisa F., Dhobi, Javeed Ahmad, Mage, Michael G, Truong, Hau, Woodward, Claire, Sgourakis, Nikolaos, Cresswell, Peter, Margulies, David H

“…Abstract T cell immunity to viruses and cancers is crucially dependent on the cell surface display of major histocompatibility complex class I (MHC-I)…”
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Targeting of intracellular oncoproteins with peptide-centric CARs by Yarmarkovich, Mark, Marshall, Quinlen F., Warrington, John M., Premaratne, Rasika, Farrel, Alvin, Groff, David, Li, Wei, di Marco, Moreno, Runbeck, Erin, Truong, Hau, Toor, Jugmohit S., Tripathi, Sarvind, Nguyen, Son, Shen, Helena, Noel, Tiffany, Church, Nicole L., Weiner, Amber, Kendsersky, Nathan, Martinez, Dan, Weisberg, Rebecca, Christie, Molly, Eisenlohr, Laurence, Bosse, Kristopher R., Dimitrov, Dimiter S., Stevanovic, Stefan, Sgourakis, Nikolaos G., Kiefel, Ben R., Maris, John M.

“…The majority of oncogenic drivers are intracellular proteins, constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented by…”
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Retraction Note: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs by Yarmarkovich, Mark, Marshall, Quinlen F., Warrington, John M., Premaratne, Rasika, Farrel, Alvin, Groff, David, Li, Wei, di Marco, Moreno, Runbeck, Erin, Truong, Hau, Toor, Jugmohit S., Tripathi, Sarvind, Nguyen, Son, Shen, Helena, Noel, Tiffany, Church, Nicole L., Weiner, Amber, Kendsersky, Nathan, Martinez, Dan, Weisberg, Rebecca, Christie, Molly, Eisenlohr, Laurence, Bosse, Kristopher R., Dimitrov, Dimiter S., Stevanovic, Stefan, Sgourakis, Nikolaos G., Kiefel, Ben R., Maris, John M.

“…Following the publication of our manuscript, a new high-resolution structure of the HLA-A·24:02/PHOX2B peptide/10LH scFv complex by X-ray crystallography…”
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RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs by Yarmarkovich, Mark, Marshall, Quinlen F., Warrington, John M., Premaratne, Rasika, Farrel, Alvin, Groff, David, Li, Wei, di Marco, Moreno, Runbeck, Erin, Truong, Hau, Toor, Jugmohit S., Tripathi, Sarvind, Nguyen, Son, Shen, Helena, Noel, Tiffany, Church, Nicole L., Weiner, Amber, Kendsersky, Nathan, Martinez, Dan, Weisberg, Rebecca, Christie, Molly, Eisenlohr, Laurence, Bosse, Kristopher R., Dimitrov, Dimiter S., Stevanovic, Stefan, Sgourakis, Nikolaos G., Kiefel, Ben R., Maris, John M.

“…The majority of oncogenic drivers are intracellular proteins, thus constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented…”
Get full text